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    Thoc1 THO complex subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291797, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Thoc1provided by RGD
    Official Full Name
    THO complex subunit 1provided by RGD
    Primary source
    RGD:1308657
    See related
    EnsemblRapid:ENSRNOG00000015332 AllianceGenome:RGD:1308657
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LRRGT00070
    Summary
    Predicted to be involved in mRNA export from nucleus. Predicted to be located in chromosome, telomeric region; cytoplasm; and nuclear speck. Predicted to be part of THO complex part of transcription export complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human THOC1 (THO complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 137.7), Testes (RPKM 125.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Thoc1 in Genome Data Viewer
    Location:
    18p13
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (1253041..1291956)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (983824..1019123)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (1142540..1177084)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene collectin sub-family member 12 Neighboring gene RNA binding motif, single stranded interacting protein 2, pseudogene 1 Neighboring gene uncharacterized LOC134482897 Neighboring gene SEC13 homolog, nuclear pore and COPII coat complex component, pseudogene 2 Neighboring gene ubiquitin specific peptidase 14 Neighboring gene NDUFA4, mitochondrial complex associated, pseudogene 2 Neighboring gene Rho-associated coiled-coil containing protein kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The death domain protein p84N5, but not the short isoform p84N5s, is cell cycle-regulated and shuttles between the nucleus and the cytoplasm. Gasparri F, et al. FEBS Lett, 2004 Sep 10. PMID 15358532
    2. Apoptosis induced by the nuclear death domain protein p84N5 is inhibited by association with Rb protein. Doostzadeh-Cizeron J, et al. Mol Biol Cell, 1999 Oct. PMID 10512864, Free PMC Article
    3. Human hHpr1/p84/Thoc1 regulates transcriptional elongation and physically links RNA polymerase II and RNA processing factors. Li Y, et al. Mol Cell Biol, 2005 May. PMID 15870275, Free PMC Article
    4. Genome instability and transcription elongation impairment in human cells depleted of THO/TREX. Domínguez-Sánchez MS, et al. PLoS Genet, 2011 Dec. PMID 22144908, Free PMC Article
    5. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. Guo S, et al. Cancer Res, 2005 Apr 15. PMID 15833825

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of THO complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of THO complex part of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription export complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    THO complex subunit 1
    Names
    THO complex 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047850.2 → NP_001041315.1  THO complex subunit 1 isoform 2

      See identical proteins and their annotated locations for NP_001041315.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      Q6TUH4
      Related
      ENSRNOP00000079602.1, ENSRNOT00000113760.2
      Conserved Domains (2) summary
      cd08318
      Location:407 → 492
      Death_NMPP84; Death domain of Nuclear Matrix Protein P84
      pfam11957
      Location:29 → 381
      efThoc1; THO complex subunit 1 transcription elongation factor

    2. NM_001398637.1 → NP_001385566.1  THO complex subunit 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/TrEMBL
      A6KND6, F7FH27
      Related
      ENSRNOP00000101408.1, ENSRNOT00000149022.1
      Conserved Domains (2) summary
      cd08318
      Location:565 → 650
      Death_NMPP84; Death domain of Nuclear Matrix Protein P84
      pfam11957
      Location:74 → 539
      efThoc1; THO complex subunit 1 transcription elongation factor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      1253041..1291956
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277273.1 → XP_063133343.1  THO complex subunit 1 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

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