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    Cacna1h calcium voltage-gated channel subunit alpha1 H [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114862, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cacna1hprovided by RGD
    Official Full Name
    calcium voltage-gated channel subunit alpha1 Hprovided by RGD
    Primary source
    RGD:68943
    See related
    EnsemblRapid:ENSRNOG00000033893 AllianceGenome:RGD:68943
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables low voltage-gated calcium channel activity. Involved in calcium ion import; positive regulation of cardiac muscle cell contraction; and steroid hormone biosynthetic process. Located in dendrite and perikaryon. Biomarker of sciatic neuropathy. Human ortholog(s) of this gene implicated in childhood absence epilepsy and primary hyperaldosteronism. Orthologous to human CACNA1H (calcium voltage-gated channel subunit alpha1 H). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 109.0), Brain (RPKM 20.3) and 7 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Cacna1h in Genome Data Viewer
    Location:
    10q12
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14894630..14952317, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14390104..14448204, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14730932..14789201, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene tryptase alpha/beta 1 Neighboring gene tryptase beta 2 Neighboring gene tryptase gamma 1 Neighboring gene uncharacterized LOC102547952 Neighboring gene tektin 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables low voltage-gated calcium channel activity  
    enables low voltage-gated calcium channel activity PubMed 
    enables low voltage-gated calcium channel activity  
    enables low voltage-gated calcium channel activity  
    enables metal ion binding  
    enables scaffold protein binding  
    enables scaffold protein binding  
    enables voltage-gated calcium channel activity  
    enables voltage-gated calcium channel activity  
    enables voltage-gated monoatomic ion channel activity  
    enables voltage-gated sodium channel activity  
    Process Evidence Code Pubs
    involved_in aldosterone biosynthetic process  
    involved_in aldosterone biosynthetic process PubMed 
    involved_in aldosterone biosynthetic process  
    involved_in calcium ion import  
    involved_in calcium ion import PubMed 
    involved_in calcium ion import  
    involved_in calcium ion import PubMed 
    involved_in calcium ion import  
    involved_in calcium ion transmembrane transport  
    involved_in calcium ion transport PubMed 
    involved_in cellular response to hormone stimulus  
    involved_in cellular response to hormone stimulus  
    involved_in cellular response to potassium ion  
    involved_in cellular response to potassium ion  
    involved_in cortisol biosynthetic process  
    involved_in cortisol biosynthetic process PubMed 
    involved_in cortisol biosynthetic process  
    involved_in inorganic cation transmembrane transport  
    involved_in membrane depolarization during action potential  
    involved_in positive regulation of acrosome reaction  
    involved_in positive regulation of acrosome reaction  
    involved_in positive regulation of calcium ion-dependent exocytosis  
    involved_in positive regulation of cardiac muscle cell contraction PubMed 
    involved_in regulation of membrane potential  
    involved_in regulation of membrane potential  
    Component Evidence Code Pubs
    located_in caveola  
    located_in dendrite PubMed 
    is_active_in glutamatergic synapse  
    located_in membrane  
    is_active_in neuron projection  
    located_in perikaryon PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynaptic membrane  
    is_active_in presynaptic active zone membrane  
    located_in sarcolemma  
    part_of voltage-gated calcium channel complex PubMed 
    part_of voltage-gated calcium channel complex  
    part_of voltage-gated sodium channel complex  

    General protein information

    Preferred Names
    voltage-dependent T-type calcium channel subunit alpha-1H
    Names
    calcium channel, voltage-dependent, T type, alpha 1H subunit
    voltage-gated calcium channel subunit alpha Cav3.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153814.2 → NP_722521.1  voltage-dependent T-type calcium channel subunit alpha-1H

      See identical proteins and their annotated locations for NP_722521.1

      Status: PROVISIONAL

      Source sequence(s)
      AF290213
      UniProtKB/Swiss-Prot
      Q9EQ60
      UniProtKB/TrEMBL
      A6HD26
      Related
      ENSRNOP00000042239.5, ENSRNOT00000043626.5
      Conserved Domains (2) summary
      PHA03307
      Location:1878 → 2259
      PHA03307; transcriptional regulator ICP4; Provisional
      pfam00520
      Location:789 → 1023
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      14894630..14952317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268284.1 → XP_063124354.1  voltage-dependent T-type calcium channel subunit alpha-1H isoform X1

      UniProtKB/TrEMBL
      A0A8I6AUK1
    2. XM_063268286.1 → XP_063124356.1  voltage-dependent T-type calcium channel subunit alpha-1H isoform X3

      UniProtKB/TrEMBL
      A6HD26, G3V9C6
    3. XM_063268285.1 → XP_063124355.1  voltage-dependent T-type calcium channel subunit alpha-1H isoform X2

      UniProtKB/TrEMBL
      A0A8I6AUK1
    4. XM_063268287.1 → XP_063124357.1  voltage-dependent T-type calcium channel subunit alpha-1H isoform X4

      UniProtKB/TrEMBL
      A0A8I6AUK1
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