Pole4 DNA polymerase epsilon 4, accessory subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pole4provided by RGD
Official Full Name: DNA polymerase epsilon 4, accessory subunitprovided by RGD
Primary source: RGD:1307793
See related: EnsemblRapid:ENSRNOG00000006102 AllianceGenome:RGD:1307793
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable DNA binding activity and protein heterodimerization activity. Predicted to be involved in DNA-templated DNA replication. Predicted to be part of ATAC complex and epsilon DNA polymerase complex. Predicted to be active in nucleus. Orthologous to human POLE4 (DNA polymerase epsilon 4, accessory subunit). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 230.0), Kidney (RPKM 152.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (116723040..116728873, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (115165285..115171097, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (113491644..113497455, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA-templated DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in DNA-templated DNA replication	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
part_of ATAC complex	ISO Inferred from Sequence Orthology more info
part_of epsilon DNA polymerase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of epsilon DNA polymerase complex	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: DNA polymerase epsilon subunit 4

Names: DNA-directed DNA polymerase epsilon 4; polymerase (DNA) epsilon 4, accessory subunit; polymerase (DNA-directed), epsilon 4 (p12 subunit); polymerase (DNA-directed), epsilon 4, accessory subunit

NP_001102104.1

EC 2.7.7.7

XP_063142354.1

EC 2.7.7.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108634.1 → NP_001102104.1 DNA polymerase epsilon subunit 4

See identical proteins and their annotated locations for NP_001102104.1

Status: PROVISIONAL

Source sequence(s)

CH473957

UniProtKB/TrEMBL

A0A0G2K637, A6IAH9, D3Z9P5

Related

ENSRNOP00000058863.1, ENSRNOT00000067314.3

Conserved Domains (1) summary

cl23735
Location:41 → 104

H4; Histone H4, one of the four histones, along with H2A, H2B and H3, which forms the eukaryotic nucleosome core; along with H3, it plays a central role in nucleosome formation; histones bind to DNA and wrap the genetic material into "beads on a string" in ...