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    Adhfe1 alcohol dehydrogenase, iron containing, 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362474, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adhfe1provided by RGD
    Official Full Name
    alcohol dehydrogenase, iron containing, 1provided by RGD
    Primary source
    RGD:1308863
    See related
    EnsemblRapid:ENSRNOG00000007069 AllianceGenome:RGD:1308863
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable alcohol dehydrogenase (NAD+) activity and hydroxyacid-oxoacid transhydrogenase activity. Predicted to be involved in glutamate catabolic process via 2-hydroxyglutarate. Predicted to be active in mitochondrion. Orthologous to human ADHFE1 (alcohol dehydrogenase iron containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 430.7), Liver (RPKM 332.8) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adhfe1 in Genome Data Viewer
    Location:
    5q11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (14488784..14515405, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (9705966..9732580, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (9403194..9429783, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene MYB proto-oncogene like 1 Neighboring gene vexin Neighboring gene ribosome biogenesis regulator 1 homolog Neighboring gene syntrophin, gamma 1 Neighboring gene transformer 2 alpha, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Differentiation-dependent expression of Adhfe1 in adipogenesis. Kim JY, et al. Arch Biochem Biophys, 2007 Aug 1. PMID 17559793, Free PMC Article
    2. Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias. Struys EA, et al. J Inherit Metab Dis, 2005. PMID 16435184
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alcohol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alcohol dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxyacid-oxoacid transhydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxyacid-oxoacid transhydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydroxyacid-oxoacid transhydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in glutamate catabolic process via 2-hydroxyglutarate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutamate catabolic process via 2-hydroxyglutarate ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutamate catabolic process via 2-hydroxyglutarate ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    hydroxyacid-oxoacid transhydrogenase, mitochondrial
    Names
    HOT
    alcohol dehydrogenase iron-containing protein 1
    NP_001020594.1
    XP_038966130.1
    XP_038966131.1
    XP_038966133.1
    XP_038966134.1
    XP_038966136.1
    XP_038966137.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025423.1 → NP_001020594.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial

      See identical proteins and their annotated locations for NP_001020594.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097945
      UniProtKB/Swiss-Prot
      Q4QQW3
      UniProtKB/TrEMBL
      A0A8L2Q4Z6, A6JFG4
      Related
      ENSRNOP00000106825.1, ENSRNOT00000123710.1
      Conserved Domains (1) summary
      cd08190
      Location:51 → 464
      HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      14488784..14515405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110206.2 → XP_038966134.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform X3

      Conserved Domains (1) summary
      cd08190
      Location:32 → 377
      HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism

    2. XM_039110208.2 → XP_038966136.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform X4

      Conserved Domains (1) summary
      cd08190
      Location:23 → 368
      HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism

    3. XM_039110203.2 → XP_038966131.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q4Z6, A6JFG6
      Related
      ENSRNOP00000009462.6, ENSRNOT00000009462.8
      Conserved Domains (1) summary
      cd08190
      Location:3 → 416
      HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism

    4. XM_039110209.2 → XP_038966137.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform X4

      Conserved Domains (1) summary
      cd08190
      Location:23 → 368
      HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism

    5. XM_039110205.2 → XP_038966133.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform X2

      Conserved Domains (1) summary
      cd08190
      Location:44 → 389
      HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism

    6. XM_039110202.2 → XP_038966130.1  hydroxyacid-oxoacid transhydrogenase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8L2Q4Z6, A6JFG6
      Conserved Domains (1) summary
      cd08190
      Location:3 → 416
      HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4QQW3.1 GenPept UniProtKB/Swiss-Prot:Q4QQW3

    Gene LinkOut

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