Trip13 thyroid hormone receptor interactor 13 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Trip13provided by RGD
Official Full Name: thyroid hormone receptor interactor 13provided by RGD
Primary source: RGD:1308516
See related: EnsemblRapid:ENSRNOG00000015810 AllianceGenome:RGD:1308516
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including double-strand break repair; meiosis I; and negative regulation of nuclear division. Predicted to act upstream of or within germ cell development and meiosis I. Predicted to be located in male germ cell nucleus. Predicted to be active in chromosome and nucleus. Human ortholog(s) of this gene implicated in mosaic variegated aneuploidy syndrome 3. Orthologous to human TRIP13 (thyroid hormone receptor interactor 13). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 60.3), Spleen (RPKM 40.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p11

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (31185700..31230638)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (29357093..29402078)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (31967980..32012923)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within female meiosis I	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within male meiosis I	ISO Inferred from Sequence Orthology more info
involved_in meiotic recombination checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within oocyte maturation	ISO Inferred from Sequence Orthology more info
involved_in oogenesis	IEA Inferred from Electronic Annotation more info
involved_in oogenesis	ISO Inferred from Sequence Orthology more info
involved_in oogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in reciprocal meiotic recombination	IBA Inferred from Biological aspect of Ancestor more info
involved_in reciprocal meiotic recombination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within reciprocal meiotic recombination	ISO Inferred from Sequence Orthology more info
involved_in reciprocal meiotic recombination	ISO Inferred from Sequence Orthology more info
involved_in reciprocal meiotic recombination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within spermatid development	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in synaptonemal complex assembly	ISO Inferred from Sequence Orthology more info
involved_in synaptonemal complex assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in male germ cell nucleus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pachytene checkpoint protein 2 homolog

Names: TR-interacting protein 13; TRIP-13; thyroid receptor-interacting protein 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011930.1 → NP_001011930.1 pachytene checkpoint protein 2 homolog

See identical proteins and their annotated locations for NP_001011930.1

Status: PROVISIONAL

Source sequence(s)

BC083900

UniProtKB/Swiss-Prot

Q5XHZ9

UniProtKB/TrEMBL

A0A8L2R3S2, A6JUW1

Related

ENSRNOP00000021532.3, ENSRNOT00000021532.6

Conserved Domains (1) summary

cd19508
Location:121 → 319

RecA-like_Pch2-like; ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

31185700..31230638

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103353.2 → XP_038959281.1 pachytene checkpoint protein 2 homolog isoform X1

UniProtKB/Swiss-Prot

Q5XHZ9

UniProtKB/TrEMBL

A0A8L2R3S2, A6JUW1

Conserved Domains (1) summary

cd19508
Location:121 → 319

RecA-like_Pch2-like; ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains
XM_008758681.3 → XP_008756903.1 pachytene checkpoint protein 2 homolog isoform X1

See identical proteins and their annotated locations for XP_008756903.1

UniProtKB/Swiss-Prot

Q5XHZ9

UniProtKB/TrEMBL

A0A8L2R3S2, A6JUW1

Conserved Domains (1) summary

cd19508
Location:121 → 319

RecA-like_Pch2-like; ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains