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    Wfdc2 WAP four-disulfide core domain 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286888, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Wfdc2provided by RGD
    Official Full Name
    WAP four-disulfide core domain 2provided by RGD
    Primary source
    RGD:628757
    See related
    EnsemblRapid:ENSRNOG00000014739 AllianceGenome:RGD:628757
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    re4
    Summary
    Predicted to enable aspartic-type endopeptidase inhibitor activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in antibacterial humoral response and innate immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human WFDC2 (WAP four-disulfide core domain 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 937.9), Kidney (RPKM 317.0) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Wfdc2 in Genome Data Viewer
    Location:
    3q42
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (173706091..173735055)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (153286946..153314832)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (161018497..161045469)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101784 Neighboring gene bolA family member 2, pseudogene 4 Neighboring gene serine peptidase inhibitor, Kunitz type, 3 Neighboring gene WAP four-disulfide core domain 6A Neighboring gene epididymal peptidase inhibitor Neighboring gene WAP four-disulfide core domain 8 Neighboring gene WAP four-disulfide core domain 6B Neighboring gene cytidine/uridine monophosphate kinase 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. HE4 Overexpression by Ovarian Cancer Promotes a Suppressive Tumor Immune Microenvironment and Enhanced Tumor and Macrophage PD-L1 Expression. Rowswell-Turner RB, et al. J Immunol, 2021 May 15. PMID 33903172
    2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HE4 Overexpression by Ovarian Cancer Promotes a Suppressive Tumor Immune Microenvironment and Enhanced Tumor and Macrophage PD-L1 Expression.
      Title: HE4 Overexpression by Ovarian Cancer Promotes a Suppressive Tumor Immune Microenvironment and Enhanced Tumor and Macrophage PD-L1 Expression.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aspartic-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cysteine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antibacterial humoral response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    WAP four-disulfide core domain protein 2
    Names
    epididymal secretory protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173109.2 → NP_775132.1  WAP four-disulfide core domain protein 2 precursor

      See identical proteins and their annotated locations for NP_775132.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/Swiss-Prot
      Q8CHN1, Q8CHN3
      UniProtKB/TrEMBL
      A0A8L2Q9W6, A6JX96
      Related
      ENSRNOP00000077787.2, ENSRNOT00000110333.2
      Conserved Domains (2) summary
      cd00199
      Location:121 → 167
      WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...
      pfam00095
      Location:32 → 73
      WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      173706091..173735055
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104401.2 → XP_038960329.1  WAP four-disulfide core domain protein 2 isoform X2

      UniProtKB/TrEMBL
      A6JX97
      Related
      ENSRNOP00000032197.5, ENSRNOT00000039664.7
      Conserved Domains (1) summary
      cd00199
      Location:73 → 119
      WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...

    2. XM_063283178.1 → XP_063139248.1  WAP four-disulfide core domain protein 2 isoform X1

    RNA

    1. XR_010064571.1 RNA Sequence

    2. XR_001837032.3 RNA Sequence

    3. XR_005501792.2 RNA Sequence

    4. XR_005501791.2 RNA Sequence

    5. XR_010064572.1 RNA Sequence

    6. XR_005501796.2 RNA Sequence

    7. XR_005501798.2 RNA Sequence

    8. XR_005501797.2 RNA Sequence

    9. XR_005501795.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CHN3.1 GenPept UniProtKB/Swiss-Prot:Q8CHN3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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