Il1rap interleukin 1 receptor accessory protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il1rapprovided by RGD
Official Full Name: interleukin 1 receptor accessory proteinprovided by RGD
Primary source: RGD:2893
See related: EnsemblRapid:ENSRNOG00000001928 AllianceGenome:RGD:2893
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: IL-1RAcp; Il1racpb
Summary: Enables interleukin-1 receptor binding activity. Predicted to be involved in several processes, including cytokine-mediated signaling pathway; positive regulation of cytokine production; and regulation of synapse assembly. Part of protein-containing complex. Orthologous to human IL1RAP (interleukin 1 receptor accessory protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 121.4), Brain (RPKM 69.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q22

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (87567813..87704346, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (74062999..74199530, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (77456648..77593208, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Activity of Il-1 in parturition is regulated by progesterone via Il1R1/Il1R2/Il-1RAcp pathway.
Title: Interleukin (IL)-1 in rat parturition: IL-1 receptors 1 and 2 and accessory proteins abundance in pregnant rat uterus at term - regulation by progesterone.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH133894 (e-PCR)
- UniSTS:217177

d11rat92 (e-PCR)
- UniSTS:120802

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD+ nucleosidase activity	IEA Inferred from Electronic Annotation more info
enables NAD+ nucleotidase, cyclic ADP-ribose generating	IEA Inferred from Electronic Annotation more info
enables coreceptor activity	IEA Inferred from Electronic Annotation more info
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables interleukin-1 binding	TAS Traceable Author Statement more info	PubMed
enables interleukin-1 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-1 receptor activity	IEA Inferred from Electronic Annotation more info
enables interleukin-1 receptor activity	ISO Inferred from Sequence Orthology more info
enables interleukin-1 receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables interleukin-1 receptor binding	TAS Traceable Author Statement more info	PubMed
enables interleukin-33 receptor activity	IEA Inferred from Electronic Annotation more info
enables interleukin-33 receptor activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in interleukin-1-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-33-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-33-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-13 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-13 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-4 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-4 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-5 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-5 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synapse assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynaptic density assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of postsynaptic density assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynapse assembly	IEA Inferred from Electronic Annotation more info
involved_in regulation of presynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in synaptic membrane adhesion	IEA Inferred from Electronic Annotation more info
involved_in synaptic membrane adhesion	ISO Inferred from Sequence Orthology more info
involved_in trans-synaptic signaling by trans-synaptic complex	IEA Inferred from Electronic Annotation more info
involved_in trans-synaptic signaling by trans-synaptic complex	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-1 receptor accessory protein

Names: IL-1 receptor accessory protein

NP_001161312.1

EC 3.2.2.6

NP_037100.1

EC 3.2.2.6

XP_063126379.1

EC 3.2.2.6

XP_063126380.1

EC 3.2.2.6

XP_063126381.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001167840.2 → NP_001161312.1 interleukin-1 receptor accessory protein isoform b precursor

See identical proteins and their annotated locations for NP_001161312.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000011

UniProtKB/TrEMBL

D1M8S3, F1LRE8

Related

ENSRNOP00000051260.4, ENSRNOT00000043498.8

Conserved Domains (5) summary

smart00255
Location:404 → 547

TIR; Toll - interleukin 1 - resistance

cd00096
Location:145 → 150

Ig; Ig strand A [structural motif]

cd20931
Location:243 → 349

Ig3_IL1RAP; Third immunoglobulin domain of interleukin-1 receptor accessory protein (IL1RAP)

cd20992
Location:25 → 132

Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains

cl11960
Location:143 → 235

Ig; Immunoglobulin domain
NM_012968.1 → NP_037100.1 interleukin-1 receptor accessory protein precursor

See identical proteins and their annotated locations for NP_037100.1

Status: PROVISIONAL

Source sequence(s)

U48592

UniProtKB/Swiss-Prot

Q63621

UniProtKB/TrEMBL

A6JRY5, F1M9B9

Related

ENSRNOP00000002645.3, ENSRNOT00000002645.6

Conserved Domains (4) summary

cd00096
Location:262 → 346

Ig; Immunoglobulin domain

PHA02785
Location:3 → 334

PHA02785; IL-beta-binding protein; Provisional

pfam01582
Location:405 → 546

TIR; TIR domain

cl11960
Location:26 → 131

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

87567813..87704346 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063270311.1 → XP_063126381.1 interleukin-1 receptor accessory protein isoform X2

UniProtKB/TrEMBL

A0A8I6ACY6

Related

ENSRNOP00000090112.1, ENSRNOT00000105096.2
XM_063270309.1 → XP_063126379.1 interleukin-1 receptor accessory protein isoform X1

UniProtKB/TrEMBL

D1M8S3, F1LRE8
XM_063270310.1 → XP_063126380.1 interleukin-1 receptor accessory protein isoform X1

UniProtKB/TrEMBL

D1M8S3, F1LRE8