Pla2g15 phospholipase A2, group XV [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pla2g15provided by RGD
Official Full Name: phospholipase A2, group XVprovided by RGD
Primary source: RGD:1302982
See related: EnsemblRapid:ENSRNOG00000019859 AllianceGenome:RGD:1302982
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ACS; LLPL; LPLA2; Lypla3; 1-O-acylceramidesynthase
Summary: Enables O-acyltransferase activity and calcium-independent phospholipase A2 activity. Involved in ceramide metabolic process and phosphatidylcholine metabolic process. Predicted to be located in nucleoplasm. Predicted to be active in extracellular space and lysosome. Orthologous to human PLA2G15 (phospholipase A2 group XV). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 424.6), Lung (RPKM 154.7) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (50960568..50977948)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (34050685..34068070)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (38129666..38146958)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LPLA2 may be a major enzyme of pulmonary surfactant phospholipid degradation by alveolar macrophages
Title: Lysosomal phospholipase A2 is selectively expressed in alveolar macrophages.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acylglycerol O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acylglycerol O-acyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables calcium-dependent phospholipase A2 activity	IEA Inferred from Electronic Annotation more info
enables calcium-independent phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-independent phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium-independent phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
NOT enables lysophospholipase activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine 1-acylhydrolase activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A1 activity	ISO Inferred from Sequence Orthology more info
enables phospholipase A1 activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ceramide metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ceramide metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within ceramide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ceramide metabolic process	ISO Inferred from Sequence Orthology more info
involved_in diacylglycerol biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in diacylglycerol biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerophospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycerophospholipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylcholine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylcholine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylcholine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylcholine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylcholine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylethanolamine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylethanolamine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylglycerol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylglycerol metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phosphatidylserine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylserine metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysosomal phospholipase A and acyltransferase; phospholipase A2 group XV

Names: 1-O-acylceramide synthase; LCAT-like lysophospholipase; group XV phospholipase A2; lysophospholipase 3; lysosomal phospholipase A2

NP_001004277.1

EC 3.1.1.32

EC 3.1.1.4

XP_038953784.1

EC 3.1.1.32

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004277.2 → NP_001004277.1 lysosomal phospholipase A and acyltransferase precursor

See identical proteins and their annotated locations for NP_001004277.1

Status: PROVISIONAL

Source sequence(s)

BC098894

UniProtKB/Swiss-Prot

Q675A5

Related

ENSRNOP00000026996.4, ENSRNOT00000026996.7

Conserved Domains (1) summary

cl21494
Location:84 → 396

Abhydrolase; alpha/beta hydrolases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

50960568..50977948

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097856.1 → XP_038953784.1 phospholipase A2 group XV isoform X1

UniProtKB/TrEMBL

A6IYW2

Conserved Domains (1) summary

cl21494
Location:84 → 167

Abhydrolase; alpha/beta hydrolases