Nfatc1 nuclear factor of activated T-cells 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nfatc1provided by RGD
Official Full Name: nuclear factor of activated T-cells 1provided by RGD
Primary source: RGD:2319357
See related: EnsemblRapid:ENSRNOG00000017146 AllianceGenome:RGD:2319357
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and transcription coactivator binding activity. Involved in several processes, including cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; and positive regulation of macromolecule biosynthetic process. Located in nucleus; perinuclear region of cytoplasm; and sarcoplasm. Biomarker of kidney disease and osteoarthritis. Human ortholog(s) of this gene implicated in congenital heart disease and ventricular septal defect. Orthologous to human NFATC1 (nuclear factor of activated T cells 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Spleen (RPKM 80.3), Muscle (RPKM 59.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (76321386..76430997, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (74046422..74156041, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (77203517..77322690, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interruption of TRPC6-NFATC1 signaling inhibits NADPH oxidase 4 and VSMCs phenotypic switch in intracranial aneurysm.
Title: Interruption of TRPC6-NFATC1 signaling inhibits NADPH oxidase 4 and VSMCs phenotypic switch in intracranial aneurysm.
The role of NPY2R/NFATc1/DYRK1A regulatory axis in sebaceous glands for sebum synthesis.
Title: The role of NPY2R/NFATc1/DYRK1A regulatory axis in sebaceous glands for sebum synthesis.
miR-506-3p alleviates uncontrolled osteoclastogenesis via repression of RANKL/NFATc1 signaling pathway.
Title: miR-506-3p alleviates uncontrolled osteoclastogenesis via repression of RANKL/NFATc1 signaling pathway.
Calcineurin inhibitors ameliorate PAN-induced podocyte injury through the NFAT-Angptl4 pathway.
Title: Calcineurin inhibitors ameliorate PAN-induced podocyte injury through the NFAT-Angptl4 pathway.
plantar mechanical stimulation upregulates calcineurin-NFATc1 signaling in soleus muscles of hindlimb-unloaded rats
Title: Plantar mechanical stimulation prevents calcineurin-NFATc1 inactivation and slow-to-fast fiber type shift in rat soleus muscle under hindlimb unloading.
These results showed that paeonol protected against periodontitis-aggravated osteoclastogenesis and alveolar bone lesion via regulating Nrf2/NF-kappaB/NFATc1 signaling pathway.
Title: Paeonol attenuates ligation-induced periodontitis in rats by inhibiting osteoclastogenesis via regulating Nrf2/NF-κB/NFATc1 signaling pathway.
11R-VIVIT regulates the expression of NFATc1, and some other molecules in Calcineurin/NFAT signaling pathway
Title: Peptide 11R-VIVIT stimulates osteoblastogenesis through regulating the expression of nuclear factor of activated T cells cytoplasmic 1.
These data suggest that RANKL could regulate the expression of NFATc1 and cSrc mRNA in the marrow culture system.
Title: Role of RANKL in the regulation of NFATc1 and c‑Src mRNA expression in osteoclast‑like cells.
this study identified two crucial immune-related molecules-CD28 and NFATc1, as putative targets of miR-145 in human and experimental myasthenia gravis
Title: Identification of novel MicroRNA signatures linked to experimental autoimmune myasthenia gravis pathogenesis: down-regulated miR-145 promotes pathogenetic Th17 cell response.
reduced myonuclear NFATc1 accumulation is a signs of slow-type myofibre atrophy, myofibre type remodelling
Title: Increased myofiber remodelling and NFATc1-myonuclear translocation in rat postural skeletal muscle after experimental vestibular deafferentation.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH131617 (e-PCR)
- UniSTS:214900

RH135219 (e-PCR)
- UniSTS:218496

RH138517 (e-PCR)
- UniSTS:220604

d18rat45 (e-PCR)
- UniSTS:121323

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase p38 binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within B-1a B cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in aortic valve development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within aortic valve morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within branching involved in lymph vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in calcineurin-NFAT signaling cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to tumor necrosis factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in endocardial cushion development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart trabecula morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in heart valve development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart valve morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lymphangiogenesis	ISO Inferred from Sequence Orthology more info
involved_in mononuclear cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within negative regulation of keratinocyte proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of stem cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vascular associated smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in pulmonary valve development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pulmonary valve morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of hair cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to muscle activity	IEP Inferred from Expression Pattern more info	PubMed
involved_in semi-lunar valve development	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle adaptation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of stem cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transition between fast and slow fiber	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in wound healing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasm	IDA Inferred from Direct Assay more info	PubMed
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear factor of activated T-cells, cytoplasmic 1

Names: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001244933.2 → NP_001231862.2 nuclear factor of activated T-cells, cytoplasmic 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018
NM_001415721.1 → NP_001402650.1 nuclear factor of activated T-cells, cytoplasmic 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

D3ZE20

Related

ENSRNOP00000055183.5, ENSRNOT00000058382.6