Gbp7 guanylate binding protein 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gbp7provided by RGD
Official Full Name: guanylate binding protein 7provided by RGD
Primary source: RGD:1583235
See related: EnsemblRapid:ENSRNOG00000029191 AllianceGenome:RGD:1583235
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in several processes, including defense response to other organism; negative regulation of cytokine production; and regulation of signal transduction. Predicted to act upstream of or within adhesion of symbiont to host and defense response to other organism. Predicted to be located in cytoplasmic vesicle. Orthologous to human GBP7 (guanylate binding protein 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Spleen (RPKM 335.9), Thymus (RPKM 335.6) and 8 other tissues See more
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Genomic context

Location:: 2q44

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (233948774..233970532)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (231275521..231297289)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (248215324..248241278)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adhesion of symbiont to host	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interferon-beta	ISO Inferred from Sequence Orthology more info
involved_in cellular response to type II interferon	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in cytolysis in another organism	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to protozoan	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within defense response to protozoan	ISO Inferred from Sequence Orthology more info
involved_in defense response to protozoan	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type III interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: uncharacterized protein LOC685067

Names: guanylate-binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001409108.1 → NP_001396037.1 uncharacterized protein LOC685067

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A6HW64, D3ZV82

Related

ENSRNOP00000032768.6, ENSRNOT00000037181.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

233948774..233970532

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039103864.2 → XP_038959792.1 uncharacterized protein LOC685067 isoform X1

UniProtKB/TrEMBL

A6HW64, D3ZV82

Conserved Domains (2) summary

pfam02263
Location:18 → 281

GBP; Guanylate-binding protein, N-terminal domain

pfam02841
Location:283 → 579

GBP_C; Guanylate-binding protein, C-terminal domain
XM_039103865.2 → XP_038959793.1 uncharacterized protein LOC685067 isoform X1

UniProtKB/TrEMBL

A6HW64, D3ZV82

Conserved Domains (2) summary

pfam02263
Location:18 → 281

GBP; Guanylate-binding protein, N-terminal domain

pfam02841
Location:283 → 579

GBP_C; Guanylate-binding protein, C-terminal domain