Arhgap33 Rho GTPase activating protein 33 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arhgap33provided by RGD
Official Full Name: Rho GTPase activating protein 33provided by RGD
Primary source: RGD:2318374
See related: EnsemblRapid:ENSRNOG00000024677 AllianceGenome:RGD:2318374
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Snx26
Summary: Predicted to enable GTPase activator activity and protein kinase binding activity. Involved in regulation of dendritic spine morphogenesis and response to toxic substance. Located in dendritic spine. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human ARHGAP33 (Rho GTPase activating protein 33). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 27.6), Thymus (RPKM 14.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (94903566..94917074, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (85776112..85789767, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (88977460..88990780, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

MARC_4163-4164:996679454:1 (e-PCR)
- UniSTS:269338

AW324378 (e-PCR)
- UniSTS:179549

UniSTS:235645 (e-PCR)
- UniSTS:235645

RH132495 (e-PCR)
- UniSTS:215778

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in response to toxic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in small GTPase-mediated signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in fibrillar center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IMP Inferred from Mutant Phenotype more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: Rho GTPase activating protein 33; rho GTPase-activating protein 33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001432740.1 → NP_001419669.1 Rho GTPase activating protein 33 isoform a

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6AJS5, D4A9G6
NM_001432741.1 → NP_001419670.1 Rho GTPase activating protein 33 isoform a

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A0A8I6AJS5, D4A9G6
NM_001432742.1 → NP_001419671.1 Rho GTPase activating protein 33 isoform b

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

D4A9G6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

94903566..94917074 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093902.2 → XP_038949830.1 rho GTPase-activating protein 33 isoform X2

Related

ENSRNOP00000095489.1, ENSRNOT00000098974.2

Conserved Domains (3) summary

cd11835
Location:214 → 267

SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins

cd04384
Location:335 → 529

RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...

cl02563
Location:80 → 192

PX_domain; The Phox Homology domain, a phosphoinositide binding module
XM_039093910.2 → XP_038949838.1 rho GTPase-activating protein 33 isoform X2

Conserved Domains (3) summary

cd11835
Location:214 → 267

SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins

cd04384
Location:335 → 529

RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...

cl02563
Location:80 → 192

PX_domain; The Phox Homology domain, a phosphoinositide binding module
XM_039093893.2 → XP_038949821.2 rho GTPase-activating protein 33 isoform X1

Related

ENSRNOP00000033946.5, ENSRNOT00000034001.6
XM_039093911.2 → XP_038949839.1 rho GTPase-activating protein 33 isoform X2

UniProtKB/TrEMBL

A0A8I6AJS5, D4A9G6

Conserved Domains (3) summary

cd11835
Location:214 → 267

SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins

cd04384
Location:335 → 529

RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...

cl02563
Location:80 → 192

PX_domain; The Phox Homology domain, a phosphoinositide binding module
XM_063277857.1 → XP_063133927.1 rho GTPase-activating protein 33 isoform X3

UniProtKB/TrEMBL

A6J9Y1
XM_063277859.1 → XP_063133929.1 rho GTPase-activating protein 33 isoform X3

UniProtKB/TrEMBL

A6J9Y1
XM_063277862.1 → XP_063133932.1 rho GTPase-activating protein 33 isoform X3

UniProtKB/TrEMBL

A6J9Y1
XM_039093913.2 → XP_038949841.1 rho GTPase-activating protein 33 isoform X4

Conserved Domains (3) summary

cd07299
Location:125 → 237

PX_TCGAP; The phosphoinositide binding Phox Homology domain of Tc10/Cdc42 GTPase-activating protein

cd11835
Location:259 → 312

SH3_ARHGAP32_33; Src homology 3 domain of Rho GTPase-activating proteins 32 and 33, and similar proteins

cd04384
Location:380 → 574

RhoGAP_CdGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to ...