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    Susd3 sushi domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 66329, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Susd3provided by MGI
    Official Full Name
    sushi domain containing 3provided by MGI
    Primary source
    MGI:MGI:1913579
    See related
    Ensembl:ENSMUSG00000021384 AllianceGenome:MGI:1913579
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700017I11Rik; 2810440J20Rik
    Summary
    Predicted to be active in plasma membrane. Is expressed in retina outer nuclear layer and urinary system. Orthologous to human SUSD3 (sushi domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in ovary adult (RPKM 50.4), adrenal adult (RPKM 21.7) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Susd3 in Genome Data Viewer
    Location:
    13 A5; 13 25.16 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (49378993..49402197, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (49230511..49248706, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene ninjurin 1 Neighboring gene STARR-positive B cell enhancer ABC_E7237 Neighboring gene caspase recruitment domain family, member 19 Neighboring gene STARR-positive B cell enhancer ABC_E5396 Neighboring gene predicted gene, 52024 Neighboring gene STARR-positive B cell enhancer ABC_E8525 Neighboring gene STARR-positive B cell enhancer ABC_E8526 Neighboring gene STARR-positive B cell enhancer mm9_chr13:49346365-49346665 Neighboring gene RIKEN cDNA E030007A22 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:49363145-49363298 Neighboring gene FYVE, RhoGEF and PH domain containing 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:49402581-49402764 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:49402849-49403036 Neighboring gene STARR-positive B cell enhancer ABC_E4067 Neighboring gene BICD cargo adaptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. Nakano Y, et al. PLoS Genet, 2012. PMID 23055939, Free PMC Article
    2. Identification of anchor genes during kidney development defines ontological relationships, molecular subcompartments and regulatory pathways. Thiagarajan RD, et al. PLoS One, 2011 Feb 28. PMID 21386911, Free PMC Article
    3. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    sushi domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360772.2 → NP_001347701.1  sushi domain-containing protein 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC140284

    2. NM_025491.5 → NP_079767.2  sushi domain-containing protein 3 isoform 1

      See identical proteins and their annotated locations for NP_079767.2

      Status: VALIDATED

      Source sequence(s)
      AC140284
      Consensus CDS
      CCDS26498.1
      UniProtKB/Swiss-Prot
      Q80XL5, Q9CYV1, Q9D176, Q9DA86
      Related
      ENSMUSP00000061423.7, ENSMUST00000058196.13
      Conserved Domains (1) summary
      cd00033
      Location:32 → 92
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    3. NM_028340.3 → NP_082616.1  sushi domain-containing protein 3 isoform 2

      See identical proteins and their annotated locations for NP_082616.1

      Status: VALIDATED

      Source sequence(s)
      AC140284
      Consensus CDS
      CCDS56880.1
      UniProtKB/Swiss-Prot
      Q9D176
      Related
      ENSMUSP00000021816.6, ENSMUST00000021816.12
      Conserved Domains (1) summary
      cd00033
      Location:20 → 80
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      49378993..49402197 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158106.1 → XP_036013999.1  sushi domain-containing protein 3 isoform X5

      Conserved Domains (1) summary
      cd00033
      Location:41 → 101
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    2. XM_036158105.1 → XP_036013998.1  sushi domain-containing protein 3 isoform X3

    3. XM_036158103.1 → XP_036013996.1  sushi domain-containing protein 3 isoform X1

      Conserved Domains (1) summary
      cd00033
      Location:41 → 101
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    4. XM_036158104.1 → XP_036013997.1  sushi domain-containing protein 3 isoform X2

      Conserved Domains (1) summary
      cd00033
      Location:32 → 92
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

    5. XM_006516940.5 → XP_006517003.1  sushi domain-containing protein 3 isoform X4

      Conserved Domains (2) summary
      cd00033
      Location:41 → 101
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd21533
      Location:106 → 142
      MERS-CoV-like_E; Middle East respiratory syndrome-related coronavirus Envelope small membrane protein and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D176.1 GenPept UniProtKB/Swiss-Prot:Q9D176

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