Septin9 septin 9 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Septin9provided by RGD
Full Name: septin 9provided by RGD
Primary source: RGD:708523
See related: EnsemblRapid:ENSRNOG00000002807 AllianceGenome:RGD:708523
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Msf; Slpa; Sept9; Eseptin; Septin9l1
Summary: Predicted to enable GTPase activity and molecular adaptor activity. Involved in anterograde dendritic transport of neurotransmitter receptor complex. Is active in presynapse. Human ortholog(s) of this gene implicated in brachial plexus neuritis and colorectal cancer. Orthologous to human SEPTIN9 (septin 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 385.5), Thymus (RPKM 329.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.2

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (102908557..103077789)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (102409798..102579056)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (106208308..106340747)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SEPT9 Upregulation in Satellite Glial Cells Associated with Diabetic Polyneuropathy in a Type 2 Diabetes-like Rat Model.
Title: SEPT9 Upregulation in Satellite Glial Cells Associated with Diabetic Polyneuropathy in a Type 2 Diabetes-like Rat Model.
The first evidence of an interaction between septins and a nonmitotic kinesin is provided and it is suggested that SEPT9 modulates the interactions of KIF17 with membrane cargo.
Title: Septin 9 interacts with kinesin KIF17 and interferes with the mechanism of NMDA receptor cargo binding and transport.
SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling
Title: SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling.
Sept7/9b/11 form a complex that has effects on filament elongation, bundling, or disruption
Title: Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11.
These results reveal that MSF is required for the completion of cytokinesis and suggest a role that is distinct from that of Nedd5.
Title: The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in anterograde dendritic transport of neurotransmitter receptor complex	IDA Inferred from Direct Assay more info	PubMed
involved_in anterograde dendritic transport of neurotransmitter receptor complex	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterograde dendritic transport of neurotransmitter receptor complex	NAS Non-traceable Author Statement more info	PubMed
involved_in biological_process	ND No biological Data available more info
involved_in cytoskeleton-dependent cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of non-motile cilium assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of non-motile cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in protein localization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in axoneme	IEA Inferred from Electronic Annotation more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
is_active_in cell division site	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite cytoplasm	IEA Inferred from Electronic Annotation more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in non-motile cilium	IEA Inferred from Electronic Annotation more info
located_in non-motile cilium	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
part_of septin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of septin complex	IEA Inferred from Electronic Annotation more info
part_of septin complex	ISO Inferred from Sequence Orthology more info
part_of septin complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in septin ring	IBA Inferred from Biological aspect of Ancestor more info
located_in stress fiber	IEA Inferred from Electronic Annotation more info
located_in stress fiber	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: septin-9

Names: E-septin; MLL septin-like fusion; SLP; eighth septin; septin 9-like 1; septin-9-like; septin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001113497.1 → NP_001106969.1 septin-9 isoform 3

See identical proteins and their annotated locations for NP_001106969.1

Status: VALIDATED

Source sequence(s)

AF180526, AW534888, BI284394, CF977797, CO403626, DY311267

UniProtKB/TrEMBL

A6HL14

Conserved Domains (1) summary

cd01850
Location:44 → 318

CDC_Septin; CDC/Septin GTPase family
NM_031837.2 → NP_114025.2 septin-9 isoform 1

Status: VALIDATED

Source sequence(s)

AF173899, AF180525, AW534888, BI284394, CK364935, CO403626, DY311267

UniProtKB/TrEMBL

A0A8I6GM30, A6HL12

Related

ENSRNOP00000096445.1, ENSRNOT00000100054.2

Conserved Domains (2) summary

cd01850
Location:286 → 560

CDC_Septin; CDC/Septin GTPase family

COG5019
Location:268 → 573

CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
NM_176856.3 → NP_789826.2 septin-9 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6GK23, A6HL11

Related

ENSRNOP00000092999.1, ENSRNOT00000099603.2

Conserved Domains (2) summary

cd01850
Location:275 → 549

CDC_Septin; CDC/Septin GTPase family

COG5019
Location:257 → 562

CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

102908557..103077789

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039086950.2 → XP_038942878.1 septin-9 isoform X2

UniProtKB/TrEMBL

A0A8I5ZNH9, A6HL10

Related

ENSRNOP00000079555.1, ENSRNOT00000113646.2

Conserved Domains (2) summary

cd01850
Location:293 → 567

CDC_Septin; CDC/Septin GTPase family

PHA03247
Location:38 → 232

PHA03247; large tegument protein UL36; Provisional
XM_039086949.2 → XP_038942877.1 septin-9 isoform X1

UniProtKB/TrEMBL

A6HL10

Related

ENSRNOP00000102335.1, ENSRNOT00000159507.1

Conserved Domains (2) summary

cd01850
Location:288 → 562

CDC_Septin; CDC/Septin GTPase family

PHA03247
Location:33 → 227

PHA03247; large tegument protein UL36; Provisional
XM_039086952.2 → XP_038942880.1 septin-9 isoform X3

UniProtKB/TrEMBL

A6HL13

Conserved Domains (2) summary

cd01850
Location:190 → 464

CDC_Septin; CDC/Septin GTPase family

PHA03307
Location:12 → 169

PHA03307; transcriptional regulator ICP4; Provisional
XM_063269973.1 → XP_063126043.1 septin-9 isoform X3

UniProtKB/TrEMBL

A6HL13

Related

ENSRNOP00000110507.1, ENSRNOT00000130850.1
XM_039086954.2 → XP_038942882.1 septin-9 isoform X5

UniProtKB/TrEMBL

A6HL14

Conserved Domains (1) summary

cd01850
Location:44 → 318

CDC_Septin; CDC/Septin GTPase family
XM_039086953.2 → XP_038942881.1 septin-9 isoform X5

UniProtKB/TrEMBL

A6HL14

Conserved Domains (1) summary

cd01850
Location:44 → 318

CDC_Septin; CDC/Septin GTPase family
XM_063269974.1 → XP_063126044.1 septin-9 isoform X4

UniProtKB/TrEMBL

A6HL14