Slco1a5 solute carrier organic anion transporter family, member 1A5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slco1a5provided by RGD
Official Full Name: solute carrier organic anion transporter family, member 1A5provided by RGD
Primary source: RGD:70985
See related: EnsemblRapid:ENSRNOG00000086993 AllianceGenome:RGD:70985
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Oatp3; OATP-3; Slc21a7; Slco1a2
Summary: Enables bile acid transmembrane transporter activity and thyroid hormone transmembrane transporter activity. Involved in animal organ regeneration; bile acid and bile salt transport; and intestinal absorption. Located in brush border membrane. Orthologous to human SLCO1A2 (solute carrier organic anion transporter family member 1A2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 22.0), Liver (RPKM 15.2) and 6 other tissues See more
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Genomic context

Location:: 4q44

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (176903387..176985589, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (175172390..175254598, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (176445856..176528117, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inflammation-Induced Attenuation of Prostaglandin D2 Elimination across Rat Blood-Brain Barrier: Involvement of the Downregulation of Organic Anion Transporter 3 and Multidrug Resistance-Associated Protein 4.
Title: Inflammation-Induced Attenuation of Prostaglandin D(2) Elimination across Rat Blood-Brain Barrier: Involvement of the Downregulation of Organic Anion Transporter 3 and Multidrug Resistance-Associated Protein 4.
The intestinal absorption of ciprofloxacin could be affected by influx transporters such as Oatp1a5.
Title: Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide, Oatp1a5.
consistently suggested that Oatp1a5 is contributing to the intestinal absorption
Title: Involvement of organic anion transporting polypeptide 1a5 (Oatp1a5) in the intestinal absorption of endothelin receptor antagonist in rats.
the functional expression of organic anion transporting polypeptide 3 at rat choroid plexus epithelial cells and its involvement in the cerebrospinal fluid-to-blood transport of estrone-3-sulfate.
Title: In vitro study of the functional expression of organic anion transporting polypeptide 3 at rat choroid plexus epithelial cells and its involvement in the cerebrospinal fluid-to-blood transport of estrone-3-sulfate.
Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney.
Title: Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney.

Submit: New GeneRIF Correction

General gene information

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Markers

D4Rat86 (e-PCR)
- UniSTS:118878

RH130074 (e-PCR)
- UniSTS:213362

AU046939 (e-PCR)
- UniSTS:110998

D4Rat288 (e-PCR), detects polymorphism
- UniSTS:227829

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables bile acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables bile acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables monocarboxylic acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic anion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic anion transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables sodium-independent organic anion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables thyroid hormone transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
involved_in bile acid and bile salt transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in bile acid and bile salt transport	IDA Inferred from Direct Assay more info	PubMed
involved_in intestinal absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monocarboxylic acid transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in organic anion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in organic anion transport	TAS Traceable Author Statement more info	PubMed
involved_in sodium-independent organic anion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in thyroid hormone transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basal plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: solute carrier organic anion transporter family member 1A5

Names: organic anion-transporting polypeptide 3; sodium-independent organic anion transporter 3; solute carrier family 21 (fatty acid transporter) member 7; solute carrier family 21 member 7; solute carrier organic anion transporter family, member 1A2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030838.1 → NP_110465.1 solute carrier organic anion transporter family member 1A5

See identical proteins and their annotated locations for NP_110465.1

Status: PROVISIONAL

Source sequence(s)

AF083469

UniProtKB/Swiss-Prot

O88397, Q9EQR8

UniProtKB/TrEMBL

A0A8L2QP25, A6IMT1

Related

ENSRNOP00000015112.7, ENSRNOT00000015112.8

Conserved Domains (3) summary

cd06174
Location:21 → 397

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

cd01330
Location:436 → 487

KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...

TIGR00805
Location:1 → 625

oat; sodium-independent organic anion transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

176903387..176985589 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286736.1 → XP_063142806.1 solute carrier organic anion transporter family member 1A5 isoform X1

UniProtKB/Swiss-Prot

O88397, Q9EQR8

UniProtKB/TrEMBL

A0A8L2QP25, A6IMT1
XM_063286732.1 → XP_063142802.1 solute carrier organic anion transporter family member 1A5 isoform X1

UniProtKB/Swiss-Prot

O88397, Q9EQR8

UniProtKB/TrEMBL

A0A8L2QP25, A6IMT1
XM_063286731.1 → XP_063142801.1 solute carrier organic anion transporter family member 1A5 isoform X1

UniProtKB/Swiss-Prot

O88397, Q9EQR8

UniProtKB/TrEMBL

A0A8L2QP25, A6IMT1
XM_063286734.1 → XP_063142804.1 solute carrier organic anion transporter family member 1A5 isoform X1

UniProtKB/Swiss-Prot

O88397, Q9EQR8

UniProtKB/TrEMBL

A0A8L2QP25, A6IMT1
XM_063286735.1 → XP_063142805.1 solute carrier organic anion transporter family member 1A5 isoform X1

UniProtKB/Swiss-Prot

O88397, Q9EQR8

UniProtKB/TrEMBL

A0A8L2QP25, A6IMT1
XM_063286733.1 → XP_063142803.1 solute carrier organic anion transporter family member 1A5 isoform X1

UniProtKB/Swiss-Prot

O88397, Q9EQR8

UniProtKB/TrEMBL

A0A8L2QP25, A6IMT1

Related

ENSRNOP00000048288.5, ENSRNOT00000049569.6
XM_063286737.1 → XP_063142807.1 solute carrier organic anion transporter family member 1A5 isoform X2