Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Cyp27b1provided by RGD
Full Name: cytochrome P450, family 27, subfamily b, polypeptide 1provided by RGD
Primary source: RGD:69192
See related: EnsemblRapid:ENSRNOG00000046214 AllianceGenome:RGD:69192
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cyp40
Summary: Enables calcidiol 1-monooxygenase activity. Involved in several processes, including negative regulation of bone trabecula formation; positive regulation of parathyroid hormone secretion; and vitamin D catabolic process. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Used to study Wilson disease; acute kidney failure; nephrosis; and vitamin D-dependent rickets type 1A. Human ortholog(s) of this gene implicated in hepatitis B; obesity; rickets; type 1 diabetes mellitus; and vitamin D-dependent rickets type 1A. Orthologous to human CYP27B1 (cytochrome P450 family 27 subfamily B member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 10.1), Adrenal (RPKM 9.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (64756626..64761570)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (62869340..62876242)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (70333150..70340006)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Altered expression of the vitamin D metabolizing enzymes CYP27B1 and CYP24A1 under the context of prostate aging and pathologies.
Title: Altered expression of the vitamin D metabolizing enzymes CYP27B1 and CYP24A1 under the context of prostate aging and pathologies.
Vascular Calcification Induced by Chronic Kidney Disease Is Mediated by an Increase of 1alpha-Hydroxylase Expression in Vascular Smooth Muscle Cells
Title: Vascular Calcification Induced by Chronic Kidney Disease Is Mediated by an Increase of 1α-Hydroxylase Expression in Vascular Smooth Muscle Cells.
Antenatal endotoxin disrupts lung vitamin D receptor and 25-hydroxyvitamin D 1alpha-hydroxylase expression in the developing rat.
Title: Antenatal endotoxin disrupts lung vitamin D receptor and 25-hydroxyvitamin D 1α-hydroxylase expression in the developing rat.
Magnesium deficiency induces downregulation of 1alpha(OH)ase and type IIa and IIc Na/Pi cotransporters, and upregulation of 24(OH)ase in the kidney.
Title: Magnesium deficiency regulates vitamin D metabolizing enzymes and type II sodium-phosphate cotransporter mRNA expression in rats.
Two weeks following ovariectomy, in dorsal root ganglia total CYP27B1 expression dropped significantly, predominantly due to decreased expression within unmyelinated CGRP-positive neurons.
Title: Vitamin D receptor and enzyme expression in dorsal root ganglia of adult female rats: modulation by ovarian hormones.
regulation of bone CYP27B1 is unique from that in the kidney, and may play an important role in bone formation
Title: Bone CYP27B1 gene expression is increased with high dietary calcium and in mineralising osteoblasts.
In elderly rats with T2DM or IR, renal injury may cause decreased activity of renal 1-alpha hydroxylase, which may result in bone loss and disturbance in VD metabolism.
Title: The relationship among renal injury, changed activity of renal 1-alpha hydroxylase and bone loss in elderly rats with insulin resistance or Type 2 diabetes mellitus.
Decreased expression of cyp27b1 in liver and kidney of rats exposed to 137 cesium suggests a physiological adaptation in response to rise in vitamin D level.
Title: Vitamin D metabolism impairment in the rat's offspring following maternal exposure to 137cesium.
1alpha-hydroxylase is expressed in adipose tissue and is functional in cultured adipocytes.
Title: 1alpha,25-Dihydroxyvitamin D hydroxylase in adipocytes.
Data show that in type 2 diabetes mellitus or insulin resistance, insufficient renal 1-alpha hydroxylase is a precipitating factor for bone loss, and suggest that IR seems to play a major role in the pathogenesis of both IRH and bone loss in T2DM.
Title: Insufficient renal 1-alpha hydroxylase and bone homeostasis in aged rats with insulin resistance or type 2 diabetes mellitus.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcidiol 1-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcidiol 1-monooxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables calcidiol 1-monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables calcidiol 1-monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables calcidiol 1-monooxygenase activity	TAS Traceable Author Statement more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables secalciferol 1-monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables secalciferol 1-monooxygenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G1 to G0 transition	IEA Inferred from Electronic Annotation more info
involved_in G1 to G0 transition	ISO Inferred from Sequence Orthology more info
involved_in bone mineralization	IEA Inferred from Electronic Annotation more info
involved_in bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in calcitriol biosynthetic process from calciol	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcitriol biosynthetic process from calciol	IEA Inferred from Electronic Annotation more info
involved_in calcitriol biosynthetic process from calciol	ISO Inferred from Sequence Orthology more info
involved_in calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in decidualization	IEA Inferred from Electronic Annotation more info
involved_in decidualization	ISO Inferred from Sequence Orthology more info
involved_in lactation	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of bone trabecula formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of calcidiol 1-monooxygenase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of keratinocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of keratinocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of parathyroid hormone secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vitamin D 24-hydroxylase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vitamin D receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vitamin D receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of bone mineralization	IEA Inferred from Electronic Annotation more info
involved_in regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in response to cAMP	IDA Inferred from Direct Assay more info	PubMed
involved_in response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to copper ion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estrogen	IEA Inferred from Electronic Annotation more info
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	IDA Inferred from Direct Assay more info	PubMed
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to prostaglandin E	IDA Inferred from Direct Assay more info	PubMed
involved_in response to type II interferon	IEA Inferred from Electronic Annotation more info
involved_in response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in response to vitamin D	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to vitamin D	IDA Inferred from Direct Assay more info	PubMed
involved_in response to vitamin D	IEA Inferred from Electronic Annotation more info
involved_in response to vitamin D	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in vitamin D catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in vitamin D catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in vitamin D catabolic process	IEA Inferred from Electronic Annotation more info
involved_in vitamin D catabolic process	ISO Inferred from Sequence Orthology more info
involved_in vitamin D metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in vitamin D metabolic process	ISO Inferred from Sequence Orthology more info
involved_in vitamin D metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

Names: 25-OHD-1 alpha-hydroxylase; 25-hydroxyvitamin D(3) 1-alpha-hydroxylase; 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial-like; P450C1 alpha; P450VD1-alpha; VD3 1A hydroxylase; calcidiol 1-monooxygenase; cytochrome P450 subfamily XXVIIB (25-hydroxyvitamin D-1-alpha-hydroxylase) polypeptide 1; cytochrome P450 subfamily XXVIIB polypeptide 1; cytochrome P450, 40 (25-hydroxyvitamin D3 1 alpha-hydroxylase); cytochrome P450, subfamily 27b, polypeptide 1; cytochrome P450C1 alpha; cytochrome P450VD1-alpha; cytochrome p450 27B1

NP_446215.1

EC 1.14.15.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053763.1 → NP_446215.1 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial

See identical proteins and their annotated locations for NP_446215.1

Status: PROVISIONAL

Source sequence(s)

AB001992

UniProtKB/Swiss-Prot

O35076, O35132

UniProtKB/TrEMBL

A6HQR8, M0R3V1

Related

ENSRNOP00000064023.1, ENSRNOT00000072176.4

Conserved Domains (1) summary

cd20648
Location:61 → 496

CYP27B1; cytochrome P450 family 27, subfamily B, polypeptide 1, also called calcidiol 1-monooxygenase