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    Lzts1 leucine zipper tumor suppressor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266711, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Lzts1provided by RGD
    Official Full Name
    leucine zipper tumor suppressor 1provided by RGD
    Primary source
    RGD:708565
    See related
    EnsemblRapid:ENSRNOG00000011826 AllianceGenome:RGD:708565
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Psdzip70
    Summary
    Involved in regulation of dendrite morphogenesis and regulation of synaptic plasticity. Located in several cellular components, including apical plasma membrane; dendrite; and postsynaptic membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Human ortholog(s) of this gene implicated in breast carcinoma; esophageal cancer; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human LZTS1 (leucine zipper tumor suppressor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 155.0), Lung (RPKM 22.3) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lzts1 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (25309502..25364942)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (20542756..20598204)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (22250452..22306667)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene elongin-C-like Neighboring gene POTE ankyrin domain family member M like 1 Neighboring gene uncharacterized LOC102554171 Neighboring gene ATPase H+ transporting V1 subunit B2 Neighboring gene solute carrier family 18 member A1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The postsynaptic density and dendritic raft localization of PSD-Zip70, which contains an N-myristoylation sequence and leucine-zipper motifs. Konno D, et al. J Cell Sci, 2002 Dec 1. PMID 12415013
    2. Down-regulation of tumor suppressor gene FEZ1/LZTS1 in breast carcinoma involves promoter methylation and associates with metastasis. Chen L, et al. Breast Cancer Res Treat, 2009 Aug. PMID 18686028, Free PMC Article
    3. Collaboration of PSD-Zip70 with its binding partner, SPAR, in dendritic spine maturity. Maruoka H, et al. J Neurosci, 2005 Feb 9. PMID 15703396, Free PMC Article
    4. Characterization of densin-180, a new brain-specific synaptic protein of the O-sialoglycoprotein family. Apperson ML, et al. J Neurosci, 1996 Nov 1. PMID 8824323, Free PMC Article
    5. The FEZ1 gene at chromosome 8p22 encodes a leucine-zipper protein, and its expression is altered in multiple human tumors. Ishii H, et al. Proc Natl Acad Sci U S A, 1999 Mar 30. PMID 10097140, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PSD-Zip70 in collaboration with SPAR is critically involved in spine maturity, especially in the mature spine formation and the maintenance of spine maturity.
      Title: Collaboration of PSD-Zip70 with its binding partner, SPAR, in dendritic spine maturity.
    2. postsynaptic density and dendritic raft localization of PSD-Zip70
      Title: The postsynaptic density and dendritic raft localization of PSD-Zip70, which contains an N-myristoylation sequence and leucine-zipper motifs.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of dendrite morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of synaptic plasticity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of synaptic plasticity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of synaptic plasticity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendritic shaft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leucine zipper putative tumor suppressor 1
    Names
    PSD-Zip70
    leucine zipper, putative tumor suppressor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153470.2 → NP_703200.1  leucine zipper putative tumor suppressor 1

      See identical proteins and their annotated locations for NP_703200.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      Q8CFC9
      UniProtKB/TrEMBL
      A6KU68
      Related
      ENSRNOP00000015800.2, ENSRNOT00000015799.6
      Conserved Domains (2) summary
      COG1196
      Location:262 → 465
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:378 → 570
      Fez1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      25309502..25364942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039094242.2 → XP_038950170.1  leucine zipper putative tumor suppressor 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8CFC9
      UniProtKB/TrEMBL
      A6KU68
      Conserved Domains (2) summary
      COG1196
      Location:262 → 465
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam06818
      Location:378 → 570
      Fez1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CFC9.3 GenPept UniProtKB/Swiss-Prot:Q8CFC9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
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