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    Smg8 SMG8 nonsense mediated mRNA decay factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287596, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Smg8provided by RGD
    Official Full Name
    SMG8 nonsense mediated mRNA decay factorprovided by RGD
    Primary source
    RGD:1306862
    See related
    EnsemblRapid:ENSRNOG00000005769 AllianceGenome:RGD:1306862
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306862
    Summary
    Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay and regulation of protein kinase activity. Orthologous to human SMG8 (SMG8 nonsense mediated mRNA decay factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 32.6), Spleen (RPKM 29.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Smg8 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (72384012..72393746, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (71886742..71895776, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (74379224..74388838, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene yippee-like 2 Neighboring gene glycerophosphodiester phosphodiesterase domain containing 1 Neighboring gene interferon induced transmembrane protein 1, pseudogene 1 Neighboring gene uncharacterized LOC120095167 Neighboring gene proline rich 11 Neighboring gene microRNA 301a Neighboring gene spindle and kinetochore associated complex subunit 2 Neighboring gene tripartite motif-containing 37 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent, 1E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay. Yamashita A, et al. Genes Dev, 2009 May 1. PMID 19417104, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    nonsense-mediated mRNA decay factor SMG8
    Names
    protein SMG8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398589.1 → NP_001385518.1  nonsense-mediated mRNA decay factor SMG8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      D3ZQ80
      Related
      ENSRNOP00000008107.4, ENSRNOT00000008107.9
      Conserved Domains (1) summary
      pfam10220
      Location:42 → 985
      Smg8_Smg9

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      72384012..72393746 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_010055155.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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