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    Marchf9 membrane associated ring-CH-type finger 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 679272, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Marchf9provided by RGD
    Official Full Name
    membrane associated ring-CH-type finger 9provided by RGD
    Primary source
    RGD:1590688
    See related
    EnsemblRapid:ENSRNOG00000046245 AllianceGenome:RGD:1590688
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    March9; Rnf179; March-IX
    Summary
    Predicted to enable zinc ion binding activity. Predicted to be involved in protein ubiquitination. Predicted to be located in Golgi stack and trans-Golgi network. Orthologous to human MARCHF9 (membrane associated ring-CH-type finger 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 25.8), Kidney (RPKM 23.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Marchf9 in Genome Data Viewer
    Location:
    7q22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (64764346..64767824, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (62879017..62882495, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (70341989..70349126, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene methyltransferase 1, tRNA methylguanosine Neighboring gene cytochrome P450, family 27, subfamily b, polypeptide 1 Neighboring gene cyclin-dependent kinase 4 Neighboring gene tetraspanin 31 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MARCH-XI, a novel transmembrane ubiquitin ligase implicated in ubiquitin-dependent protein sorting in developing spermatids. Morokuma Y, et al. J Biol Chem, 2007 Aug 24. PMID 17604280
    2. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. Bartee E, et al. J Virol, 2004 Feb. PMID 14722266, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi stack ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MARCHF9
    Names
    E3 ubiquitin-protein ligase MARCH9
    membrane-associated RING-CH protein IX
    membrane-associated ring finger (C3HC4) 9
    membrane-associated ring finger 9
    NP_001094071.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100601.1 → NP_001094071.1  E3 ubiquitin-protein ligase MARCHF9

      See identical proteins and their annotated locations for NP_001094071.1

      Status: PROVISIONAL

      Source sequence(s)
      AB048842
      UniProtKB/TrEMBL
      A6P321
      Related
      ENSRNOP00000067861.3, ENSRNOT00000072468.4
      Conserved Domains (1) summary
      smart00744
      Location:109 → 155
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      64764346..64767824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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