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    Mipol1 mirror-image polydactyly 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100911970, updated on 9-Dec-2024

    Summary

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    Symbol
    Mipol1provided by RGD
    Full Name
    mirror-image polydactyly 1provided by RGD
    Primary source
    RGD:6504372
    See related
    EnsemblRapid:ENSRNOG00000009151 AllianceGenome:RGD:6504372
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be located in nucleus. Orthologous to human MIPOL1 (mirror-image polydactyly 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 20.6), Adrenal (RPKM 19.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mipol1 in Genome Data Viewer
    Location:
    6q23
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (80490330..80825413)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (74755293..75090403)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (78172842..78506232)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 21 Neighboring gene uncharacterized LOC120103539 Neighboring gene transfer RNA valine (anticodon AAC) 44 Neighboring gene U6 spliceosomal RNA Neighboring gene phosphoribosyl pyrophosphate synthetase 1-like 3 Neighboring gene forkhead box A1 Neighboring gene U2 spliceosomal RNA Neighboring gene tetratricopeptide repeat domain 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Chromosome 14 transfer and functional studies identify a candidate tumor suppressor gene, mirror image polydactyly 1, in nasopharyngeal carcinoma. Cheung AK, et al. Proc Natl Acad Sci U S A, 2009 Aug 25. PMID 19667180, Free PMC Article
    2. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mirror-image polydactyly gene 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001399384.2 → NP_001386313.1  mirror-image polydactyly gene 1 protein

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6A2D3, A0A8I6GH45, A6HBP3
      Related
      ENSRNOP00000104410.1, ENSRNOT00000156613.1
      Conserved Domains (1) summary
      COG4372
      Location:216 → 390
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      80490330..80825413
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008764677.3 → XP_008762899.1  mirror-image polydactyly gene 1 protein isoform X1

      See identical proteins and their annotated locations for XP_008762899.1

      UniProtKB/TrEMBL
      A0A8I6A2D3, F1LUS3
      Related
      ENSRNOP00000012282.8, ENSRNOT00000012282.9
      Conserved Domains (1) summary
      TIGR02168
      Location:62 → 379
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. XM_039113186.2 → XP_038969114.1  mirror-image polydactyly gene 1 protein isoform X2

      Conserved Domains (1) summary
      COG4372
      Location:103 → 250
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

    3. XM_039113190.2 → XP_038969118.1  mirror-image polydactyly gene 1 protein isoform X3

      Conserved Domains (1) summary
      COG4372
      Location:78 → 225
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

    4. XM_039113193.2 → XP_038969121.1  mirror-image polydactyly gene 1 protein isoform X5

    5. XM_039113192.2 → XP_038969120.1  mirror-image polydactyly gene 1 protein isoform X4

      Conserved Domains (1) summary
      COG4372
      Location:66 → 213
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]

    6. XM_039113194.2 → XP_038969122.1  mirror-image polydactyly gene 1 protein isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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