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    Ttc14 tetratricopeptide repeat domain 14 [ Mus musculus (house mouse) ]

    Gene ID: 67120, updated on 3-Dec-2024

    Summary

    Official Symbol
    Ttc14provided by MGI
    Official Full Name
    tetratricopeptide repeat domain 14provided by MGI
    Primary source
    MGI:MGI:1914370
    See related
    Ensembl:ENSMUSG00000027677 AllianceGenome:MGI:1914370
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    cI-44; mKIAA1980; 2700016E08Rik; 4930434D01Rik; 4931403I22Rik; 4933402I15Rik
    Summary
    Predicted to enable nucleic acid binding activity. Orthologous to human TTC14 (tetratricopeptide repeat domain 14). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 13.0), cortex adult (RPKM 11.9) and 26 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Ttc14 in Genome Data Viewer
    Location:
    3 A3; 3 16.32 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (33853923..33869009)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (33799798..33814860)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 42203 Neighboring gene heat shock protein 1 (chaperonin) pseudogene Neighboring gene coiled-coil domain containing 39 Neighboring gene STARR-seq mESC enhancer starr_07362 Neighboring gene predicted gene, 42204 Neighboring gene STARR-positive B cell enhancer ABC_E11180 Neighboring gene predicted gene, 23175

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1980

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    tetratricopeptide repeat protein 14
    Names
    TPR repeat protein 14

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290500.2NP_001277429.1  tetratricopeptide repeat protein 14 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region compared to variant 1. The encoded isoform (c) is shorter than isoform a.
      Source sequence(s)
      AC154395
      Consensus CDS
      CCDS71232.1
      UniProtKB/Swiss-Prot
      G3X9T5, Q69Z51, Q8BRX6, Q8CD24, Q8CDF8, Q8R3Q9, Q9CSP9
      UniProtKB/TrEMBL
      E9PXW3
      Related
      ENSMUSP00000112450.4, ENSMUST00000117915.8
      Conserved Domains (4) summary
      smart00316
      Location:123206
      S1; Ribosomal protein S1-like RNA-binding domain
      sd00006
      Location:254282
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:288321
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:254319
      TPR_11; TPR repeat
    2. NM_001290502.2NP_001277431.1  tetratricopeptide repeat protein 14 isoform d

      See identical proteins and their annotated locations for NP_001277431.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in both UTRs, uses an alternate splice site in the 5' coding region and an alternate 3' terminal exon. These difference cause translation initiation at an alternate start codon compared to variant 1. The encoded isoform (d) is shorter and has novel N- and C-termini compared to isoform a.
      Source sequence(s)
      AC154395
      Consensus CDS
      CCDS79895.1
      UniProtKB/TrEMBL
      A0A0G2JGX7
      Related
      ENSMUSP00000143738.2, ENSMUST00000200271.5
      Conserved Domains (4) summary
      smart00316
      Location:120203
      S1; Ribosomal protein S1-like RNA-binding domain
      sd00006
      Location:303331
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:337370
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:303368
      TPR_11; TPR repeat
    3. NM_001404037.1NP_001390966.1  tetratricopeptide repeat protein 14 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC154395
      UniProtKB/TrEMBL
      A0A0G2JEQ6
    4. NM_001404038.1NP_001390967.1  tetratricopeptide repeat protein 14 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC154395
      UniProtKB/TrEMBL
      A0A0G2JEQ6
    5. NM_001404039.1NP_001390968.1  tetratricopeptide repeat protein 14 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC154395
      UniProtKB/TrEMBL
      A0A0G2JEQ6
      Related
      ENSMUSP00000142863.2, ENSMUST00000196369.2
    6. NM_001404040.1NP_001390969.1  tetratricopeptide repeat protein 14 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC154395
      UniProtKB/TrEMBL
      A0A0G2JEQ6
    7. NM_001404041.1NP_001390970.1  tetratricopeptide repeat protein 14 isoform g

      Status: VALIDATED

      Source sequence(s)
      AC154395
      UniProtKB/TrEMBL
      A0A0G2JEQ6
    8. NM_001404042.1NP_001390971.1  tetratricopeptide repeat protein 14 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC154395
      UniProtKB/Swiss-Prot
      G3X9T5, Q69Z51, Q8BRX6, Q8CD24, Q8CDF8, Q8R3Q9, Q9CSP9
    9. NM_025978.5NP_080254.2  tetratricopeptide repeat protein 14 isoform b

      See identical proteins and their annotated locations for NP_080254.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate structure in the 3' UTR and 3' coding region compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC154395
      Consensus CDS
      CCDS17303.1
      UniProtKB/TrEMBL
      A0A0G2JE97, A6H6N9
      Related
      ENSMUSP00000096757.4, ENSMUST00000099153.10
      Conserved Domains (4) summary
      smart00316
      Location:123206
      S1; Ribosomal protein S1-like RNA-binding domain
      sd00006
      Location:306334
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:340373
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:306371
      TPR_11; TPR repeat
    10. NM_027619.5NP_081895.2  tetratricopeptide repeat protein 14 isoform a

      See identical proteins and their annotated locations for NP_081895.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform (a).
      Source sequence(s)
      AC154395
      Consensus CDS
      CCDS38410.1
      UniProtKB/Swiss-Prot
      G3X9T5, Q69Z51, Q8BRX6, Q8CD24, Q8CDF8, Q8R3Q9, Q9CSP9
      UniProtKB/TrEMBL
      A0A8V5I5B0
      Related
      ENSMUSP00000103845.5, ENSMUST00000108210.9
      Conserved Domains (4) summary
      smart00316
      Location:123206
      S1; Ribosomal protein S1-like RNA-binding domain
      sd00006
      Location:306334
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:340373
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:306371
      TPR_11; TPR repeat

    RNA

    1. NR_175794.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154395
    2. NR_175795.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154395
    3. NR_175796.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154395
    4. NR_175797.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154395
    5. NR_175798.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC154395

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      33853923..33869009
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163240.1XP_036019133.1  tetratricopeptide repeat protein 14 isoform X7

      UniProtKB/TrEMBL
      A0A0G2JEX0, A0A0G2JF90
      Related
      ENSMUSP00000142935.2, ENSMUST00000199222.5
      Conserved Domains (3) summary
      smart00316
      Location:123206
      S1; Ribosomal protein S1-like RNA-binding domain
      COG0457
      Location:289430
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:306334
      TPR; TPR repeat [structural motif]
    2. XM_006535522.4XP_006535585.1  tetratricopeptide repeat protein 14 isoform X1

      UniProtKB/Swiss-Prot
      G3X9T5, Q69Z51, Q8BRX6, Q8CD24, Q8CDF8, Q8R3Q9, Q9CSP9
      Conserved Domains (3) summary
      smart00316
      Location:154237
      S1; Ribosomal protein S1-like RNA-binding domain
      COG0457
      Location:256415
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:285313
      TPR; TPR repeat [structural motif]
    3. XM_011249707.4XP_011248009.1  tetratricopeptide repeat protein 14 isoform X6

      UniProtKB/TrEMBL
      A0A0G2JF90
      Conserved Domains (3) summary
      smart00316
      Location:154237
      S1; Ribosomal protein S1-like RNA-binding domain
      COG0457
      Location:320461
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:337365
      TPR; TPR repeat [structural motif]
    4. XM_011249706.4XP_011248008.1  tetratricopeptide repeat protein 14 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JF90
      Conserved Domains (3) summary
      smart00316
      Location:154237
      S1; Ribosomal protein S1-like RNA-binding domain
      COG0457
      Location:320473
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:337365
      TPR; TPR repeat [structural motif]
    5. XM_036163238.1XP_036019131.1  tetratricopeptide repeat protein 14 isoform X3

      Conserved Domains (3) summary
      COG0457
      Location:75222
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:92120
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:102140
      TPR_11; TPR repeat
    6. XM_030252768.2XP_030108628.1  tetratricopeptide repeat protein 14 isoform X4

      Conserved Domains (3) summary
      COG0457
      Location:11170
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:4068
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:5088
      TPR_11; TPR repeat

    RNA

    1. XR_880651.4 RNA Sequence