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    Usp42 ubiquitin specific peptidase 42 [ Mus musculus (house mouse) ]

    Gene ID: 76800, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Usp42provided by MGI
    Official Full Name
    ubiquitin specific peptidase 42provided by MGI
    Primary source
    MGI:MGI:1924050
    See related
    Ensembl:ENSMUSG00000051306 AllianceGenome:MGI:1924050
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D5Ertd591e; 2410140K03Rik; 3110031A07Rik; A630018G05Rik
    Summary
    Enables cysteine-type deubiquitinase activity. Involved in protein deubiquitination. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; eye; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human USP42 (ubiquitin specific peptidase 42). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 13.7), CNS E11.5 (RPKM 4.9) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Usp42 in Genome Data Viewer
    Location:
    5 G2; 5 82.5 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (143696077..143741600, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (143710325..143759753, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54311 Neighboring gene cytohesin 3 Neighboring gene predicted gene, 38737 Neighboring gene RIKEN cDNA D130017N08 gene Neighboring gene STARR-positive B cell enhancer ABC_E10364 Neighboring gene STARR-positive B cell enhancer ABC_E2182 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 1 Neighboring gene ankyrin repeat domain 61

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The expression of Usp42 during embryogenesis and spermatogenesis in mouse. Kim YK, et al. Gene Expr Patterns, 2007 Jan. PMID 16904385
    2. Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Pettitt SJ, et al. Nat Methods, 2009 Jul. PMID 19525957, Free PMC Article
    3. Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen. Adissu HA, et al. Dis Model Mech, 2014 May. PMID 24652767, Free PMC Article
    4. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 42
    Names
    deubiquitinating enzyme 42
    ubiquitin specific protease 42
    ubiquitin thioesterase 42
    ubiquitin thiolesterase 42
    ubiquitin-specific-processing protease 42
    NP_084025.2
    XP_006504817.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029749.2 → NP_084025.2  ubiquitin carboxyl-terminal hydrolase 42

      See identical proteins and their annotated locations for NP_084025.2

      Status: VALIDATED

      Source sequence(s)
      AC136746
      Consensus CDS
      CCDS39372.1
      UniProtKB/Swiss-Prot
      B2RQC2
      Related
      ENSMUSP00000053955.6, ENSMUST00000053287.6
      Conserved Domains (3) summary
      cd02661
      Location:109 → 409
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam05642
      Location:723 → 870
      Sporozoite_P67; Sporozoite P67 surface antigen
      pfam05109
      Location:420 → 795
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      143696077..143741600 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504754.5 → XP_006504817.1  ubiquitin carboxyl-terminal hydrolase 42 isoform X1

      See identical proteins and their annotated locations for XP_006504817.1

      UniProtKB/Swiss-Prot
      B2RQC2
      Conserved Domains (3) summary
      cd02661
      Location:109 → 409
      Peptidase_C19E; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      pfam05642
      Location:723 → 870
      Sporozoite_P67; Sporozoite P67 surface antigen
      pfam05109
      Location:420 → 795
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RQC2.1 GenPept UniProtKB/Swiss-Prot:B2RQC2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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