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    Tek TEK receptor tyrosine kinase [ Mus musculus (house mouse) ]

    Gene ID: 21687, updated on 10-Dec-2024

    Summary

    Official Symbol
    Tekprovided by MGI
    Official Full Name
    TEK receptor tyrosine kinaseprovided by MGI
    Primary source
    MGI:MGI:98664
    See related
    Ensembl:ENSMUSG00000006386 AllianceGenome:MGI:98664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hyk; STK1; Tie2; Tie-2; Cd202b
    Summary
    Enables protein tyrosine kinase activity and signaling receptor activity. Involved in several processes, including circulatory system development; negative regulation of endothelial cell apoptotic process; and response to retinoic acid. Acts upstream of or within several processes, including positive regulation of macromolecule metabolic process; positive regulation of protein import into nucleus; and regulation of non-canonical NF-kappaB signal transduction. Located in perinuclear region of cytoplasm. Is expressed in several structures, including cardiovascular system; central nervous system; extraembryonic component; genitourinary system; and immune system. Human ortholog(s) of this gene implicated in arteriovenous malformation; multiple cutaneous and mucosal venous malformations; and renal Wilms' tumor. Orthologous to human TEK (TEK receptor tyrosine kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 28.4), subcutaneous fat pad adult (RPKM 7.5) and 18 other tissues See more
    Orthologs
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    Genomic context

    See Tek in Genome Data Viewer
    Location:
    4 C5; 4 43.34 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (94627322..94763213)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (94739086..94874976)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene intraflagellar transport 74 Neighboring gene STARR-seq mESC enhancer starr_10791 Neighboring gene microRNA 872 Neighboring gene STARR-seq mESC enhancer starr_10792 Neighboring gene predicted gene, 40205 Neighboring gene STARR-seq mESC enhancer starr_10794 Neighboring gene equatorin, sperm acrosome associated Neighboring gene predicted gene 12693

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 27
    Function Evidence Code Pubs
    enables ATP binding  
    enables GPI-linked ephrin receptor activity  
    enables boss receptor activity  
    enables brain-derived neurotrophic factor receptor activity  
    enables epidermal growth factor receptor activity  
    enables fibroblast growth factor receptor activity  
    enables growth factor binding  
    enables hepatocyte growth factor receptor activity  
    enables histone H2AXY142 kinase activity  
    enables histone H3Y41 kinase activity  
    enables identical protein binding  
    enables insulin receptor activity  
    enables insulin-like growth factor receptor activity  
    enables macrophage colony-stimulating factor receptor activity  
    enables placental growth factor receptor activity  
    enables platelet-derived growth factor alpha-receptor activity  
    enables platelet-derived growth factor beta-receptor activity  
    enables protein binding PubMed 
    enables protein tyrosine kinase activity PubMed 
    enables protein tyrosine kinase activity  
    enables protein tyrosine kinase collagen receptor activity  
    enables signaling receptor activity PubMed 
    enables stem cell factor receptor activity  
    enables transmembrane receptor protein tyrosine kinase activity  
    enables transmembrane receptor protein tyrosine kinase activity  
    enables transmembrane-ephrin receptor activity  
    enables vascular endothelial growth factor receptor activity  
    Items 1 - 25 of 27
    Items 1 - 25 of 79
    Process Evidence Code Pubs
    involved_in Kit signaling pathway  
    involved_in Tie signaling pathway  
    involved_in Tie signaling pathway  
    involved_in Tie signaling pathway PubMed 
    involved_in angiogenesis  
    acts_upstream_of_or_within angiogenesis PubMed 
    involved_in angiogenesis PubMed 
    involved_in angiogenesis PubMed 
    involved_in brain-derived neurotrophic factor receptor signaling pathway  
    involved_in branching involved in blood vessel morphogenesis PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    involved_in cell surface receptor protein tyrosine kinase signaling pathway  
    acts_upstream_of_or_within cell-cell adhesion PubMed 
    acts_upstream_of_or_within cell-matrix adhesion PubMed 
    involved_in chromatin remodeling  
    involved_in collagen-activated tyrosine kinase receptor signaling pathway  
    involved_in endothelial cell proliferation  
    involved_in endothelial cell proliferation PubMed 
    involved_in ephrin receptor signaling pathway  
    involved_in epidermal growth factor receptor signaling pathway  
    involved_in fibroblast growth factor receptor signaling pathway  
    involved_in glomerulus vasculature development  
    involved_in heart development PubMed 
    involved_in heart trabecula formation PubMed 
    acts_upstream_of_or_within hemopoiesis PubMed 
    involved_in hepatocyte growth factor receptor signaling pathway  
    involved_in insulin receptor signaling pathway  
    involved_in insulin-like growth factor receptor signaling pathway  
    involved_in macrophage colony-stimulating factor signaling pathway  
    involved_in multicellular organism development  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of angiogenesis  
    acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
    involved_in negative regulation of endothelial cell apoptotic process PubMed 
    involved_in peptidyl-tyrosine phosphorylation PubMed 
    involved_in platelet-derived growth factor receptor-alpha signaling pathway  
    involved_in platelet-derived growth factor receptor-beta signaling pathway  
    involved_in positive regulation of ERK1 and ERK2 cascade  
    acts_upstream_of_or_within_positive_effect positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of angiogenesis  
    involved_in positive regulation of angiogenesis  
    acts_upstream_of_or_within positive regulation of cell adhesion PubMed 
    acts_upstream_of_or_within positive regulation of cytokine production involved in immune response PubMed 
    involved_in positive regulation of endothelial cell migration  
    involved_in positive regulation of endothelial cell migration  
    involved_in positive regulation of endothelial cell migration  
    involved_in positive regulation of endothelial cell migration PubMed 
    involved_in positive regulation of focal adhesion assembly  
    involved_in positive regulation of focal adhesion assembly  
    involved_in positive regulation of intracellular signal transduction  
    involved_in positive regulation of intracellular signal transduction  
    acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    acts_upstream_of_or_within_positive_effect positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    acts_upstream_of_or_within positive regulation of protein import into nucleus PubMed 
    acts_upstream_of_or_within positive regulation of protein phosphorylation PubMed 
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of vascular endothelial growth factor receptor signaling pathway PubMed 
    acts_upstream_of_or_within regulation of angiogenesis PubMed 
    acts_upstream_of_or_within regulation of cell migration PubMed 
    acts_upstream_of_or_within regulation of cell migration PubMed 
    involved_in regulation of endothelial cell proliferation PubMed 
    involved_in regulation of establishment or maintenance of cell polarity  
    involved_in regulation of establishment or maintenance of cell polarity  
    acts_upstream_of_or_within regulation of non-canonical NF-kappaB signal transduction PubMed 
    involved_in response to estrogen  
    involved_in response to hypoxia  
    involved_in response to retinoic acid PubMed 
    involved_in sprouting angiogenesis  
    involved_in sprouting angiogenesis  
    involved_in substrate adhesion-dependent cell spreading  
    involved_in substrate adhesion-dependent cell spreading  
    involved_in vascular endothelial growth factor receptor-1 signaling pathway  
    involved_in vascular endothelial growth factor signaling pathway  
    involved_in vasculogenesis PubMed 
    Items 1 - 25 of 79
    Component Evidence Code Pubs
    colocalizes_with actin filament  
    located_in apical plasma membrane  
    located_in basal plasma membrane  
    located_in basolateral plasma membrane  
    located_in cell surface  
    located_in cell-cell junction  
    located_in centriolar satellite  
    located_in cytoskeleton  
    located_in extracellular region  
    located_in focal adhesion  
    located_in membrane PubMed 
    located_in membrane raft  
    located_in microvillus  
    located_in perinuclear region of cytoplasm PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    part_of receptor complex  
    colocalizes_with stress fiber  

    General protein information

    Preferred Names
    angiopoietin-1 receptor
    Names
    endothelial tyrosine kinase
    endothelial-specific receptor tyrosine kinase
    p140 TEK
    tunica interna endothelial cell kinase
    tyrosine kinase with Ig and EGF homology domains-2
    tyrosine-protein kinase receptor TEK
    tyrosine-protein kinase receptor TIE-2
    NP_001277478.1
    NP_001277480.1
    NP_038718.2
    XP_006502993.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001290549.1NP_001277478.1  angiopoietin-1 receptor isoform 2 precursor

      See identical proteins and their annotated locations for NP_001277478.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter by an amino acid, compared to isoform 1.
      Source sequence(s)
      AL772277, AL954716
      Consensus CDS
      CCDS71421.1
      UniProtKB/Swiss-Prot
      Q02858
      Related
      ENSMUSP00000071162.6, ENSMUST00000071168.6
      Conserved Domains (7) summary
      cd05088
      Location:8141116
      PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
      smart00221
      Location:8221090
      STYKc; Protein kinase; unclassified specificity
      cd00055
      Location:230275
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00063
      Location:638730
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:542625
      fn3; Fibronectin type III domain
      pfam07974
      Location:311340
      EGF_2; EGF-like domain
      pfam10430
      Location:24118
      Ig_Tie2_1; Tie-2 Ig-like domain 1
    2. NM_001290551.1NP_001277480.1  angiopoietin-1 receptor isoform 3 precursor

      See identical proteins and their annotated locations for NP_001277480.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 3, which lacks an internal segment and is shorter, compared to isoform 1.
      Source sequence(s)
      AL772277, AL954716
      Consensus CDS
      CCDS80122.1
      UniProtKB/TrEMBL
      Q80YS4
      Related
      ENSMUSP00000073595.7, ENSMUST00000073939.13
      Conserved Domains (6) summary
      cd05088
      Location:7641066
      PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
      smart00221
      Location:7721040
      STYKc; Protein kinase; unclassified specificity
      cd00055
      Location:179224
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00063
      Location:587679
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:491574
      fn3; Fibronectin type III domain
      pfam10430
      Location:24118
      Ig_Tie2_1; Tie-2 Ig-like domain 1
    3. NM_013690.3NP_038718.2  angiopoietin-1 receptor isoform 1 precursor

      See identical proteins and their annotated locations for NP_038718.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL772277, AL954716
      Consensus CDS
      CCDS18361.1
      UniProtKB/TrEMBL
      B1AWS8
      Related
      ENSMUSP00000099862.2, ENSMUST00000102798.8
      Conserved Domains (7) summary
      cd05088
      Location:8151117
      PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
      smart00221
      Location:8231091
      STYKc; Protein kinase; unclassified specificity
      cd00055
      Location:230275
      EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
      cd00063
      Location:638730
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:542625
      fn3; Fibronectin type III domain
      pfam07974
      Location:311340
      EGF_2; EGF-like domain
      pfam10430
      Location:24118
      Ig_Tie2_1; Tie-2 Ig-like domain 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      94627322..94763213
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502930.4XP_006502993.1  angiopoietin-1 receptor isoform X1

      Conserved Domains (3) summary
      cd05088
      Location:589891
      PTKc_Tie2; Catalytic domain of the Protein Tyrosine Kinase, Tie2
      cd00063
      Location:412504
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:316398
      fn3; Fibronectin type III domain
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