Kyat1 kynurenine aminotransferase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kyat1provided by MGI
Official Full Name: kynurenine aminotransferase 1provided by MGI
Primary source: MGI:MGI:1917516
See related: Ensembl:ENSMUSG00000039648 AllianceGenome:MGI:1917516
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gtk; Kat1; KatI; Ccbl1; 2010009K05Rik
Summary: Predicted to enable cysteine-S-conjugate beta-lyase activity; protein homodimerization activity; and transaminase activity. Acts upstream of or within response to bacterium. Predicted to be located in cytosol. Predicted to be active in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; integumental system; respiratory system; and sensory organ. Orthologous to human KYAT1 (kynurenine aminotransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver adult (RPKM 63.7), liver E18 (RPKM 19.9) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 21.31 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (30075136..30096307, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (30185124..30206295, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

One is the native structure with the cofactor in the PLP form bound to Lys247 with the highest resolution yet available for KAT-I at 1.28 A resolution, and the other with the general PLP-dependent aminotransferase inhibitor, aminooxyacetate (AOAA) covalently bound to the cofactor at 1.54 A.
Title: High resolution crystal structures of human kynurenine aminotransferase-I bound to PLP cofactor, and in complex with aminooxyacetate.
KAT I inhibited by equimolar tryptophan and half-life is 69.7 minutes at 65 degree C.
Title: Thermal stability, pH dependence and inhibition of four murine kynurenine aminotransferases.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-S-conjugate beta-lyase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-S-conjugate beta-lyase activity	ISO Inferred from Sequence Orthology more info
enables glutamine-phenylpyruvate transaminase activity	IEA Inferred from Electronic Annotation more info
enables glutamine-phenylpyruvate transaminase activity	ISO Inferred from Sequence Orthology more info
enables kynurenine-oxoglutarate transaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kynurenine-oxoglutarate transaminase activity	ISO Inferred from Sequence Orthology more info
enables kynurenine-oxoglutarate transaminase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-kynurenine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in L-kynurenine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in kynurenine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in kynurenine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in pyruvate metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kynurenine--oxoglutarate transaminase 1

Names: cysteine conjugate-beta lyase 1; cysteine-S-conjugate beta-lyase; cytoplasmic (glutamine transaminase K, kyneurenine aminotransferase); glutamine transaminase K; glutamine--phenylpyruvate transaminase; kynurenine aminotransferase I; kynurenine--oxoglutarate transaminase I

NP_001343403.1

EC 2.6.1.64

EC 2.6.1.7

EC 4.4.1.13

NP_001343404.1

EC 2.6.1.64

EC 2.6.1.7

EC 4.4.1.13

NP_765992.2

EC 2.6.1.64

EC 2.6.1.7

EC 4.4.1.13

XP_006498378.1

EC 2.6.1.64

EC 2.6.1.7

EC 4.4.1.13

XP_006498380.1

EC 2.6.1.64

EC 2.6.1.7

EC 4.4.1.13

XP_030107921.1

EC 2.6.1.64

EC 2.6.1.7

EC 4.4.1.13

XP_036018454.1

EC 2.6.1.64

EC 2.6.1.7

EC 4.4.1.13

XP_036018455.1

EC 2.6.1.64

EC 2.6.1.7

EC 4.4.1.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356474.2 → NP_001343403.1 kynurenine--oxoglutarate transaminase 1 isoform a

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AL845258

Consensus CDS

CCDS15874.1

UniProtKB/Swiss-Prot

Q8BTY1, Q8BY27

UniProtKB/TrEMBL

A2AQY9, Q05CI8

Related

ENSMUSP00000038612.4, ENSMUST00000044038.10

Conserved Domains (1) summary

cl27741
Location:23 → 420

Aminotran_1_2; Aminotransferase class I and II
NM_001356475.2 → NP_001343404.1 kynurenine--oxoglutarate transaminase 1 isoform b

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.

Source sequence(s)

AL845258

UniProtKB/TrEMBL

A2AQY9

Related

ENSMUST00000148555.8

Conserved Domains (1) summary

PRK08912
Location:3 → 362

PRK08912; aminotransferase
NM_001434246.1 → NP_001421175.1 kynurenine--oxoglutarate transaminase 1 isoform b

Status: VALIDATED

Source sequence(s)

AL845258
NM_001434247.1 → NP_001421176.1 kynurenine--oxoglutarate transaminase 1 isoform c

Status: VALIDATED

Source sequence(s)

AL845258
NM_172404.4 → NP_765992.2 kynurenine--oxoglutarate transaminase 1 isoform a

See identical proteins and their annotated locations for NP_765992.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AL845258

Consensus CDS

CCDS15874.1

UniProtKB/Swiss-Prot

Q8BTY1, Q8BY27

UniProtKB/TrEMBL

A2AQY9, Q05CI8

Related

ENSMUSP00000109293.3, ENSMUST00000113663.9

Conserved Domains (1) summary

cl27741
Location:23 → 420

Aminotran_1_2; Aminotransferase class I and II

RNA

NR_197769.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL845258
NR_197770.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL845258

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

30075136..30096307 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006498315.2 → XP_006498378.1 kynurenine--oxoglutarate transaminase 1 isoform X1

Conserved Domains (1) summary

PRK08912
Location:218 → 569

PRK08912; aminotransferase
XM_030252061.2 → XP_030107921.1 kynurenine--oxoglutarate transaminase 1 isoform X4

UniProtKB/TrEMBL

A2AQY8

Conserved Domains (1) summary

PRK08912
Location:2 → 333

PRK08912; aminotransferase
XM_036162561.1 → XP_036018454.1 kynurenine--oxoglutarate transaminase 1 isoform X3

UniProtKB/TrEMBL

A2AQY9

Conserved Domains (1) summary

PRK08912
Location:3 → 362

PRK08912; aminotransferase
XM_036162562.1 → XP_036018455.1 kynurenine--oxoglutarate transaminase 1 isoform X4

UniProtKB/TrEMBL

A2AQY8

Conserved Domains (1) summary

PRK08912
Location:2 → 333

PRK08912; aminotransferase
XM_006498317.4 → XP_006498380.1 kynurenine--oxoglutarate transaminase 1 isoform X2

Conserved Domains (1) summary

PRK08912
Location:25 → 391

PRK08912; aminotransferase