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    Zbtb5 zinc finger and BTB domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 230119, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zbtb5provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 5provided by MGI
    Primary source
    MGI:MGI:1924601
    See related
    Ensembl:ENSMUSG00000049657 AllianceGenome:MGI:1924601
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0354; 5930421I10; 9430083K24Rik
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including cardiovascular system; genitourinary system; gut; nervous system; and skin. Orthologous to human ZBTB5 (zinc finger and BTB domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 8.9), whole brain E14.5 (RPKM 8.8) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Zbtb5 in Genome Data Viewer
    Location:
    4 B1; 4 23.66 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (44991242..45012412, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (44991242..45012412, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8808 Neighboring gene STARR-positive B cell enhancer ABC_E2110 Neighboring gene predicted gene 12679 Neighboring gene STARR-positive B cell enhancer ABC_E6170 Neighboring gene glyoxylate reductase/hydroxypyruvate reductase Neighboring gene RIKEN cDNA 1700055D18 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:45025246-45025433 Neighboring gene STARR-positive B cell enhancer ABC_E71 Neighboring gene STARR-seq mESC enhancer starr_10090 Neighboring gene polymerase (RNA) I polypeptide E Neighboring gene F-box protein 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    General gene information

    Markers

    Clone Names

    • KIAA0354

    General protein information

    Preferred Names
    zinc finger and BTB domain-containing protein 5
    Names
    expressed in brain and neural tube
    transcription factor ZNF-POZ

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163283.1NP_001156755.1  zinc finger and BTB domain-containing protein 5

      See identical proteins and their annotated locations for NP_001156755.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      BC054551, BC057545, CN665638
      Consensus CDS
      CCDS18129.1
      UniProtKB/Swiss-Prot
      Q3TVR7, Q6GV09, Q7TQG0, Q8BIB5
      Related
      ENSMUSP00000136507.2, ENSMUST00000180217.2
      Conserved Domains (4) summary
      smart00225
      Location:25119
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:608628
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:14119
      BTB; BTB/POZ domain
      pfam13465
      Location:620645
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001163284.1NP_001156756.1  zinc finger and BTB domain-containing protein 5

      See identical proteins and their annotated locations for NP_001156756.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
      Source sequence(s)
      BC054551, BC057545
      Consensus CDS
      CCDS18129.1
      UniProtKB/Swiss-Prot
      Q3TVR7, Q6GV09, Q7TQG0, Q8BIB5
      Related
      ENSMUSP00000103447.3, ENSMUST00000107817.3
      Conserved Domains (4) summary
      smart00225
      Location:25119
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:608628
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:14119
      BTB; BTB/POZ domain
      pfam13465
      Location:620645
      zf-H2C2_2; Zinc-finger double domain
    3. NM_173399.3NP_775575.2  zinc finger and BTB domain-containing protein 5

      See identical proteins and their annotated locations for NP_775575.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
      Source sequence(s)
      BC054551, BC057545
      Consensus CDS
      CCDS18129.1
      UniProtKB/Swiss-Prot
      Q3TVR7, Q6GV09, Q7TQG0, Q8BIB5
      Related
      ENSMUSP00000059919.9, ENSMUST00000055028.9
      Conserved Domains (4) summary
      smart00225
      Location:25119
      BTB; Broad-Complex, Tramtrack and Bric a brac
      sd00017
      Location:608628
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:14119
      BTB; BTB/POZ domain
      pfam13465
      Location:620645
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      44991242..45012412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)