Epha8 Eph receptor A8 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Epha8provided by MGI
Official Full Name: Eph receptor A8provided by MGI
Primary source: MGI:MGI:109378
See related: Ensembl:ENSMUSG00000028661 AllianceGenome:MGI:109378
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Eek; Hek3; mKIAA1459
Summary: Enables GPI-linked ephrin receptor activity and growth factor binding activity. Involved in several processes, including ephrin receptor signaling pathway; neuron development; and positive regulation of intracellular signal transduction. Acts upstream of or within cellular response to follicle-stimulating hormone stimulus. Located in neuron projection and plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human EPHA8 (EPH receptor A8). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in cerebellum adult (RPKM 13.1), CNS E18 (RPKM 11.1) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 69.05 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (136656729..136684170, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (136929419..136956859, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that Odin levels play a critical role in regulating the stability of EphA2 and A8 in response to ligand stimulation and by modulating the ubiquitination process.
Title: The SAM domains of Anks family proteins are critically involved in modulating the degradation of EphA receptors.
These findings support a possible function for Anks family proteins as scaffolding proteins of the EphA8 signaling pathway.
Title: Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function.
1-kb enhancer region, directs expression in the embryo to the anterior region of the developing midbrain.
Title: Identification of an enhancer region in the mouse ephA8 locus directing expression to the anterior region of the dorsal mesencephalon.
Regulation of EphA8 gene expression is accomplished by TALE homeobox transcription factors during development of the mesencephalon.
Title: Regulation of EphA8 gene expression by TALE homeobox transcription factors during development of the mesencephalon.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Epha8 (e-PCR), detects polymorphism
- UniSTS:495886

NoName (e-PCR)
- UniSTS:548486

Epha8 (e-PCR), detects polymorphism
- UniSTS:527338

Epha4 (e-PCR), detects polymorphism
- UniSTS:266987

AW047546 (e-PCR)
- UniSTS:165365

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables GPI-linked ephrin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables boss receptor activity	IEA Inferred from Electronic Annotation more info
enables brain-derived neurotrophic factor receptor activity	IEA Inferred from Electronic Annotation more info
enables ephrin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables epidermal growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables fibroblast growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables hepatocyte growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXY142 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3Y41 kinase activity	IEA Inferred from Electronic Annotation more info
enables insulin receptor activity	IEA Inferred from Electronic Annotation more info
enables insulin-like growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables macrophage colony-stimulating factor receptor activity	IEA Inferred from Electronic Annotation more info
enables placental growth factor receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor alpha-receptor activity	IEA Inferred from Electronic Annotation more info
enables platelet-derived growth factor beta-receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase collagen receptor activity	IEA Inferred from Electronic Annotation more info
enables stem cell factor receptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane-ephrin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane-ephrin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Kit signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in brain-derived neurotrophic factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to follicle-stimulating hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in collagen-activated tyrosine kinase receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ephrin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ephrin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in insulin-like growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in macrophage colony-stimulating factor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in platelet-derived growth factor receptor-alpha signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in platelet-derived growth factor receptor-beta signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell adhesion mediated by integrin	IDA Inferred from Direct Assay more info	PubMed
involved_in substrate-dependent cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in vascular endothelial growth factor receptor-1 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ephrin type-A receptor 8

Names: EPH- and ELK-related kinase; Ephrin type-A receptor 8 precursor (Tyrosine-protein kinase receptor EEK) (EPH-and ELK-related kinase); tyrosine-protein kinase receptor EEK

NP_001407844.1

EC 2.7.10.1

NP_031965.2

EC 2.7.10.1

XP_036019550.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001420915.1 → NP_001407844.1 ephrin type-A receptor 8 isoform 2

Status: VALIDATED

Source sequence(s)

AL627214
NM_007939.3 → NP_031965.2 ephrin type-A receptor 8 isoform 1 precursor

See identical proteins and their annotated locations for NP_031965.2

Status: VALIDATED

Source sequence(s)

AL627214

Consensus CDS

CCDS18813.1

UniProtKB/Swiss-Prot

A3KG07, O09127

UniProtKB/TrEMBL

Q5DTX7

Related

ENSMUSP00000030420.9, ENSMUST00000030420.9

Conserved Domains (8) summary

cd09550
Location:932 → 994

SAM_EPH-A8; SAM domain of EPH-A8 subfamily of tyrosine kinase receptors

smart00454
Location:933 → 993

SAM; Sterile alpha motif

cd10486
Location:30 → 202

EphR_LBD_A8; Ligand Binding Domain of Ephrin type-A Receptor 8

cd00063
Location:439 → 530

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:329 → 422

fn3; Fibronectin type III domain

pfam07714
Location:634 → 891

Pkinase_Tyr; Protein tyrosine kinase

pfam14575
Location:565 → 629

EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

cl21453
Location:629 → 895

PKc_like; Protein Kinases, catalytic domain

RNA

NR_185215.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL627214
NR_185216.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL627214

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

136656729..136684170 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163657.1 → XP_036019550.1 ephrin type-A receptor 8 isoform X1

UniProtKB/TrEMBL

Q5DTX7

Conserved Domains (4) summary

cd09550
Location:930 → 992

SAM_EPH-A8; SAM domain of EPH-A8 subfamily of tyrosine kinase receptors

cd10486
Location:30 → 202

EphR_LBD_A8; Ligand Binding Domain of Ephrin type-A Receptor 8

pfam00041
Location:438 → 521

fn3; Fibronectin type III domain

cl21453
Location:627 → 893

PKc_like; Protein Kinases, catalytic domain