U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Aatk apoptosis-associated tyrosine kinase [ Mus musculus (house mouse) ]

    Gene ID: 11302, updated on 3-Dec-2024

    Summary

    Official Symbol
    Aatkprovided by MGI
    Official Full Name
    apoptosis-associated tyrosine kinaseprovided by MGI
    Primary source
    MGI:MGI:1197518
    See related
    Ensembl:ENSMUSG00000025375 AllianceGenome:MGI:1197518
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AATYK; aatyk1; mKIAA0641
    Summary
    Enables protein tyrosine kinase activity. Acts upstream of or within brain development; neuron apoptotic process; and peptidyl-tyrosine autophosphorylation. Predicted to be located in several cellular components, including dendrite; growth cone; and perinuclear region of cytoplasm. Is expressed in brain; corpus callosum; spinal cord; spinal cord gray matter; and spinal cord white matter. Orthologous to human AATK (apoptosis associated tyrosine kinase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 51.8), cortex adult (RPKM 38.4) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Aatk in Genome Data Viewer
    Location:
    11 E2; 11 83.96 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (119898137..119938009, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120007311..120047183, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31337 Neighboring gene STARR-positive B cell enhancer ABC_E2379 Neighboring gene predicted gene 11767 Neighboring gene predicted gene, 57802 Neighboring gene brain-specific angiogenesis inhibitor 1-associated protein 2 Neighboring gene microRNA 3065 Neighboring gene microRNA 338 Neighboring gene centrosomal protein 131 Neighboring gene STARR-positive B cell enhancer ABC_E4021 Neighboring gene STARR-positive B cell enhancer ABC_E206 Neighboring gene TEPSIN, adaptor related protein complex 4 accessory protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serine/threonine-protein kinase LMTK1
    Names
    apoptosis-associated tyrosine kinase 1B
    brain apoptosis-associated tyrosine kinase
    lemur tyrosine kinase 1
    NP_001185714.1
    NP_001185716.1
    NP_001364432.1
    NP_001389718.1
    NP_031403.2
    XP_006532054.1
    XP_006532055.1
    XP_006532056.1
    XP_006532057.1
    XP_036012124.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198785.1NP_001185714.1  serine/threonine-protein kinase LMTK1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and contains an in-frame upstream start codon compared to variant 1. This variant encodes a protein (isoform 2) with a longer N-terminus than isoform 1.
      Source sequence(s)
      AB288871, BC042837, BC080846
      Consensus CDS
      CCDS56826.1
      UniProtKB/Swiss-Prot
      A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
      UniProtKB/TrEMBL
      B1AZF3
      Related
      ENSMUSP00000067181.4, ENSMUST00000064307.10
      Conserved Domains (3) summary
      smart00221
      Location:138405
      STYKc; Protein kinase; unclassified specificity
      cd05087
      Location:137407
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
      pfam12429
      Location:828880
      DUF3676; Protein of unknown function (DUF3676)
    2. NM_001198787.1NP_001185716.1  serine/threonine-protein kinase LMTK1 isoform 1

      See identical proteins and their annotated locations for NP_001185716.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant, and encodes isoform 1. Variants 1 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AK036705, BC080846
      Consensus CDS
      CCDS25725.1
      UniProtKB/Swiss-Prot
      A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
      UniProtKB/TrEMBL
      B1AZF9
      Related
      ENSMUSP00000099308.2, ENSMUST00000103019.2
      Conserved Domains (3) summary
      smart00221
      Location:81348
      STYKc; Protein kinase; unclassified specificity
      cd05087
      Location:80350
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
      pfam12429
      Location:771823
      DUF3676; Protein of unknown function (DUF3676)
    3. NM_001377503.1NP_001364432.1  serine/threonine-protein kinase LMTK1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL953913
      UniProtKB/Swiss-Prot
      A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
      Conserved Domains (2) summary
      PHA03307
      Location:473904
      PHA03307; transcriptional regulator ICP4; Provisional
      cl21453
      Location:1230
      PKc_like; Protein Kinases, catalytic domain
    4. NM_001402789.1NP_001389718.1  serine/threonine-protein kinase LMTK1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL953913
      UniProtKB/Swiss-Prot
      A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
    5. NM_007377.4NP_031403.2  serine/threonine-protein kinase LMTK1 isoform 1

      See identical proteins and their annotated locations for NP_031403.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Variants 1 and 3 encode the same protein (isoform 1).
      Source sequence(s)
      BC042837, BC080846
      Consensus CDS
      CCDS25725.1
      UniProtKB/Swiss-Prot
      A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
      UniProtKB/TrEMBL
      B1AZF9
      Related
      ENSMUSP00000099309.2, ENSMUST00000103020.8
      Conserved Domains (3) summary
      smart00221
      Location:81348
      STYKc; Protein kinase; unclassified specificity
      cd05087
      Location:80350
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
      pfam12429
      Location:771823
      DUF3676; Protein of unknown function (DUF3676)

    RNA

    1. NR_165305.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL953913
    2. NR_165306.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL953913
    3. NR_175298.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL953913

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      119898137..119938009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006531991.3XP_006532054.1  serine/threonine-protein kinase LMTK1 isoform X1

      UniProtKB/Swiss-Prot
      A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
      Conserved Domains (2) summary
      PHA03307
      Location:6501081
      PHA03307; transcriptional regulator ICP4; Provisional
      cd05087
      Location:137407
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
    2. XM_006531993.3XP_006532056.1  serine/threonine-protein kinase LMTK1 isoform X4

      See identical proteins and their annotated locations for XP_006532056.1

      UniProtKB/Swiss-Prot
      A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
      Related
      ENSMUST00000150730.8
      Conserved Domains (2) summary
      PHA03307
      Location:5931024
      PHA03307; transcriptional regulator ICP4; Provisional
      cd05087
      Location:80350
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
    3. XM_006531994.4XP_006532057.1  serine/threonine-protein kinase LMTK1 isoform X4

      See identical proteins and their annotated locations for XP_006532057.1

      UniProtKB/Swiss-Prot
      A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
      Conserved Domains (2) summary
      PHA03307
      Location:5931024
      PHA03307; transcriptional regulator ICP4; Provisional
      cd05087
      Location:80350
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
    4. XM_006531992.5XP_006532055.1  serine/threonine-protein kinase LMTK1 isoform X2

      UniProtKB/Swiss-Prot
      A6BLY8, O35211, Q3U2U5, Q3UHR8, Q66JN3, Q80YE3, Q80YE4, Q8CB63, Q8CHE2
      Conserved Domains (2) summary
      PHA03307
      Location:6011032
      PHA03307; transcriptional regulator ICP4; Provisional
      cd05087
      Location:88358
      PTKc_Aatyk1; Catalytic domain of the Protein Tyrosine Kinases, Apoptosis-associated tyrosine kinase 1
    5. XM_036156231.1XP_036012124.1  serine/threonine-protein kinase LMTK1 isoform X5

      Related
      ENSMUST00000142959.2
      Conserved Domains (1) summary
      PHA03307
      Location:240671
      PHA03307; transcriptional regulator ICP4; Provisional

    RNA

    1. XR_003949229.1 RNA Sequence