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    Tnfsf8 tumor necrosis factor (ligand) superfamily, member 8 [ Mus musculus (house mouse) ]

    Gene ID: 21949, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tnfsf8provided by MGI
    Official Full Name
    tumor necrosis factor (ligand) superfamily, member 8provided by MGI
    Primary source
    MGI:MGI:88328
    See related
    Ensembl:ENSMUSG00000028362 AllianceGenome:MGI:88328
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CD153; Cd30l; CD30LG; Tnlg3a
    Summary
    Predicted to enable cytokine activity and tumor necrosis factor receptor binding activity. Acts upstream of or within CD8-positive, alpha-beta T cell differentiation; defense response to Gram-positive bacterium; and positive regulation of transcription by RNA polymerase II. Predicted to be located in extracellular space and membrane. Is expressed in renal vasculature. Orthologous to human TNFSF8 (TNF superfamily member 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See Tnfsf8 in Genome Data Viewer
    Location:
    4 C1; 4 34.06 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (63749439..63779745, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (63831202..63861508, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 42294 Neighboring gene tumor necrosis factor (ligand) superfamily, member 15 Neighboring gene STARR-seq mESC enhancer starr_10447 Neighboring gene ribosomal protein L17, pseudogene 4 Neighboring gene RIKEN cDNA 8030451A03 gene Neighboring gene STARR-seq mESC enhancer starr_10448 Neighboring gene STARR-seq mESC enhancer starr_10449 Neighboring gene tenascin C

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables tumor necrosis factor receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    tumor necrosis factor ligand superfamily member 8
    Names
    CD30 ligand
    CD30-L
    tumor necrosis factor ligand 3a

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009403.3NP_033429.1  tumor necrosis factor ligand superfamily member 8

      See identical proteins and their annotated locations for NP_033429.1

      Status: PROVISIONAL

      Source sequence(s)
      AK030916
      Consensus CDS
      CCDS18264.1
      UniProtKB/Swiss-Prot
      P32972
      UniProtKB/TrEMBL
      Q3U033, Q544U1
      Related
      ENSMUSP00000030047.3, ENSMUST00000030047.3
      Conserved Domains (1) summary
      pfam00229
      Location:118235
      TNF; TNF(Tumour Necrosis Factor) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      63749439..63779745 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320114.2XP_017175603.1  tumor necrosis factor ligand superfamily member 8 isoform X1

      UniProtKB/TrEMBL
      Q3U033
      Conserved Domains (1) summary
      pfam00229
      Location:95211
      TNF; TNF(tumor Necrosis Factor) family
    2. XM_036163967.1XP_036019860.1  tumor necrosis factor ligand superfamily member 8 isoform X2

      UniProtKB/TrEMBL
      Q3U033
      Conserved Domains (1) summary
      cl00147
      Location:118187
      TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...