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    Kifc2 kinesin family member C2 [ Mus musculus (house mouse) ]

    Gene ID: 16581, updated on 3-Dec-2024

    Summary

    Official Symbol
    Kifc2provided by MGI
    Official Full Name
    kinesin family member C2provided by MGI
    Primary source
    MGI:MGI:109187
    See related
    Ensembl:ENSMUSG00000004187 AllianceGenome:MGI:109187
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement and mitotic spindle assembly. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleus. Is expressed in several structures, including 4-cell stage embryo; alimentary system; genitourinary system; nervous system; and sensory organ. Orthologous to human KIFC2 (kinesin family member C2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 113.0), frontal lobe adult (RPKM 87.4) and 10 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Kifc2 in Genome Data Viewer
    Location:
    15 D3; 15 36.23 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (76543984..76552396)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (76659784..76668196)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene tonsoku-like, DNA repair protein Neighboring gene STARR-positive B cell enhancer ABC_E1481 Neighboring gene zinc finger TRAF type containing 1 Neighboring gene predicted gene, 57852 Neighboring gene STARR-positive B cell enhancer ABC_E760 Neighboring gene STARR-positive B cell enhancer ABC_E9419 Neighboring gene STARR-positive B cell enhancer ABC_E3145 Neighboring gene transmembrane protein 276 Neighboring gene STARR-positive B cell enhancer ABC_E5491 Neighboring gene forkhead box H1 Neighboring gene STARR-seq mESC enhancer starr_39060 Neighboring gene protein phosphatase 1, regulatory subunit 16A Neighboring gene glutamic pyruvic transaminase, soluble

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables plus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in anterograde dendritic transport of neurotransmitter receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in synaptic vesicle transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    NOT located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358909.2NP_001345838.1  kinesin-like protein KIFC2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (4) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC156550
      Consensus CDS
      CCDS88791.1
      UniProtKB/TrEMBL
      A0A2R8W6X1, Q3UNC4
      Related
      ENSMUSP00000155536.2, ENSMUST00000230451.2
      Conserved Domains (2) summary
      COG1196
      Location:145266
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01366
      Location:322649
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    2. NM_001358910.2NP_001345839.1  kinesin-like protein KIFC2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (4) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC156550
      Consensus CDS
      CCDS88791.1
      UniProtKB/TrEMBL
      A0A2R8W6X1, Q3UNC4
      Conserved Domains (2) summary
      COG1196
      Location:145266
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01366
      Location:322649
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    3. NM_001358911.2NP_001345840.1  kinesin-like protein KIFC2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AC156550
      UniProtKB/Swiss-Prot
      O08613, O08672
      Conserved Domains (2) summary
      cd01366
      Location:390717
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      cl25732
      Location:224336
      SMC_N; RecF/RecN/SMC N terminal domain
    4. NM_001358912.2NP_001345841.1  kinesin-like protein KIFC2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC156550
      UniProtKB/Swiss-Prot
      O08613, O08672
      Conserved Domains (2) summary
      cd01366
      Location:387714
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      cl25732
      Location:237325
      SMC_N; RecF/RecN/SMC N terminal domain
    5. NM_001416290.1NP_001403219.1  kinesin-like protein KIFC2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC156550
      UniProtKB/TrEMBL
      A0A2R8W6X1, Q3UNC4
    6. NM_001416296.1NP_001403225.1  kinesin-like protein KIFC2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC156550
      UniProtKB/TrEMBL
      Q3UNC4
    7. NM_001416297.1NP_001403226.1  kinesin-like protein KIFC2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC156550
      UniProtKB/Swiss-Prot
      O08613, O08672
    8. NM_001416298.1NP_001403227.1  kinesin-like protein KIFC2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC156550
      UniProtKB/Swiss-Prot
      O08613, O08672
    9. NM_001416299.1NP_001403228.1  kinesin-like protein KIFC2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC156550
      UniProtKB/Swiss-Prot
      O08613, O08672
    10. NM_001416300.1NP_001403229.1  kinesin-like protein KIFC2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC156550
      UniProtKB/Swiss-Prot
      O08613, O08672
    11. NM_001416301.1NP_001403230.1  kinesin-like protein KIFC2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC156550
      UniProtKB/TrEMBL
      Q3UNC4
    12. NM_001416302.1NP_001403231.1  kinesin-like protein KIFC2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC156550
      UniProtKB/TrEMBL
      Q3UNC4
    13. NM_001416303.1NP_001403232.1  kinesin-like protein KIFC2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC156550
      UniProtKB/TrEMBL
      Q3UNC4
    14. NM_001416304.1NP_001403233.1  kinesin-like protein KIFC2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC156550
      UniProtKB/Swiss-Prot
      O08613, O08672
    15. NM_001416305.1NP_001403234.1  kinesin-like protein KIFC2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC156550
    16. NM_001416306.1NP_001403235.1  kinesin-like protein KIFC2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC156550
    17. NM_001416307.1NP_001403236.1  kinesin-like protein KIFC2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC156550
    18. NM_001416308.1NP_001403237.1  kinesin-like protein KIFC2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC156550
    19. NM_010630.4NP_034760.2  kinesin-like protein KIFC2 isoform 1

      See identical proteins and their annotated locations for NP_034760.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC156550
      Consensus CDS
      CCDS27583.1
      UniProtKB/Swiss-Prot
      O08613, O08672
      UniProtKB/TrEMBL
      G3X8Q6
      Related
      ENSMUSP00000004294.11, ENSMUST00000004294.12
      Conserved Domains (2) summary
      smart00129
      Location:409735
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01366
      Location:407734
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    RNA

    1. NR_183664.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156550
    2. NR_183665.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156550
      Related
      ENSMUST00000230964.2
    3. NR_183666.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC156550

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      76543984..76552396
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248350.2XP_030104210.1  kinesin-like protein KIFC2 isoform X3

      Conserved Domains (1) summary
      cd01366
      Location:68395
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    2. XM_030248356.1XP_030104216.1  kinesin-like protein KIFC2 isoform X3

      Conserved Domains (1) summary
      cd01366
      Location:68395
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    3. XM_030248351.1XP_030104211.1  kinesin-like protein KIFC2 isoform X3

      Conserved Domains (1) summary
      cd01366
      Location:68395
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    4. XM_030248349.1XP_030104209.1  kinesin-like protein KIFC2 isoform X3

      Conserved Domains (1) summary
      cd01366
      Location:68395
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    5. XM_030248346.2XP_030104206.1  kinesin-like protein KIFC2 isoform X1

      UniProtKB/TrEMBL
      A0A2R8W6X1, Q3UNC4
      Related
      ENSMUST00000230124.2
      Conserved Domains (2) summary
      COG1196
      Location:145266
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd01366
      Location:322649
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    6. XM_036159191.1XP_036015084.1  kinesin-like protein KIFC2 isoform X2

      UniProtKB/TrEMBL
      Q3UNC4
      Conserved Domains (1) summary
      cd01366
      Location:305632
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
    7. XM_036159193.1XP_036015086.1  kinesin-like protein KIFC2 isoform X3

      Conserved Domains (1) summary
      cd01366
      Location:68395
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

    RNA

    1. XR_383988.3 RNA Sequence

    2. XR_001781497.3 RNA Sequence