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    Pfdn5 prefoldin 5 [ Mus musculus (house mouse) ]

    Gene ID: 56612, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pfdn5provided by MGI
    Official Full Name
    prefoldin 5provided by MGI
    Primary source
    MGI:MGI:1928753
    See related
    Ensembl:ENSMUSG00000001289 AllianceGenome:MGI:1928753
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eig1; MM-1; D15Ertd697e; 1190001O17Rik; 1700010A06Rik
    Summary
    Predicted to enable amyloid-beta binding activity and unfolded protein binding activity. Acts upstream of or within retina development in camera-type eye. Predicted to be located in cytosol and intermediate filament cytoskeleton. Predicted to be part of prefoldin complex. Predicted to be active in cytoplasm. Is expressed in brain; cartilage; genitourinary system; gut gland; and trachea. Orthologous to human PFDN5 (prefoldin subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 164.4), testis adult (RPKM 156.9) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Pfdn5 in Genome Data Viewer
    Location:
    15 F2; 15 57.48 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (102234551..102239925)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (102326116..102331490)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_39829 Neighboring gene major facilitator superfamily domain containing 5 Neighboring gene STARR-positive B cell enhancer ABC_E5520 Neighboring gene extra spindle pole bodies 1, separase Neighboring gene STARR-positive B cell enhancer ABC_E7421 Neighboring gene STARR-positive B cell enhancer ABC_E7422 Neighboring gene microRNA 12187 Neighboring gene melanocyte proliferating gene 1 Neighboring gene achalasia, adrenocortical insufficiency, alacrimia Neighboring gene STARR-seq mESC enhancer starr_39832

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables amyloid-beta binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables unfolded protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intermediate filament cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intermediate filament cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of prefoldin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of prefoldin complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of prefoldin complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    prefoldin subunit 5
    Names
    C-myc-binding protein Mm-1
    EIG-1
    c-myc binding protein MM-1
    myc modulator 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027044.3NP_081320.2  prefoldin subunit 5

      See identical proteins and their annotated locations for NP_081320.2

      Status: VALIDATED

      Source sequence(s)
      AF108357, CN835522
      Consensus CDS
      CCDS37227.1
      UniProtKB/Swiss-Prot
      Q3UKS8, Q9JMJ8, Q9WU28
      UniProtKB/TrEMBL
      Q6ZWY7
      Related
      ENSMUSP00000129178.2, ENSMUST00000166658.8
      Conserved Domains (1) summary
      TIGR00293
      Location:12138
      TIGR00293; prefoldin, archaeal alpha subunit/eukaryotic subunit 5

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      102234551..102239925
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_020031.1: Suppressed sequence

      Description
      NM_020031.1: This RefSeq was permanently suppressed because it was based on a chimeric source sequence (AB011473.1), and the N-terminus of the encoded protein is not supported.