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    Tnc tenascin C [ Mus musculus (house mouse) ]

    Gene ID: 21923, updated on 9-Dec-2024

    Summary

    Official Symbol
    Tncprovided by MGI
    Official Full Name
    tenascin Cprovided by MGI
    Primary source
    MGI:MGI:101922
    See related
    Ensembl:ENSMUSG00000028364 AllianceGenome:MGI:101922
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TN; Hxb; Ten; TN-C; cytotactin; tenascin-C; C130033P17Rik
    Summary
    Predicted to enable fibronectin binding activity; integrin binding activity; and syndecan binding activity. Involved in several processes, including neuromuscular junction development; peripheral nervous system axon regeneration; and regulation of inflammatory response. Acts upstream of or within positive regulation of cell population proliferation; positive regulation of gene expression; and prostate gland development. Located in basement membrane; extracellular region; and interstitial matrix. Part of tenascin complex. Is active in perisynaptic extracellular matrix. Is expressed in several structures, including alimentary system; brain; heart and pericardium; immune system; and skeletal system. Human ortholog(s) of this gene implicated in allergic conjunctivitis; asthma; autosomal dominant nonsyndromic deafness 56; and pulmonary hypertension. Orthologous to human TNC (tenascin C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in ovary adult (RPKM 49.7), bladder adult (RPKM 28.6) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tnc in Genome Data Viewer
    Location:
    4 C1; 4 34.06 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (63878022..63965554, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (63959785..64047015, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10447 Neighboring gene tumor necrosis factor (ligand) superfamily, member 8 Neighboring gene ribosomal protein L17, pseudogene 4 Neighboring gene RIKEN cDNA 8030451A03 gene Neighboring gene STARR-seq mESC enhancer starr_10448 Neighboring gene STARR-seq mESC enhancer starr_10449 Neighboring gene predicted gene, 31115 Neighboring gene STARR-seq mESC enhancer starr_10450 Neighboring gene STARR-seq mESC enhancer starr_10451 Neighboring gene predicted gene 11217 Neighboring gene STARR-seq mESC enhancer starr_10452 Neighboring gene STARR-seq mESC enhancer starr_10453 Neighboring gene STARR-seq mESC enhancer starr_10454 Neighboring gene predicted gene, 23950

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (6)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC144208, MGC144209

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables extracellular matrix structural constituent RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    enables fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables integrin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables syndecan binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in bud outgrowth involved in lung branching IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bud outgrowth involved in lung branching ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to prostaglandin D stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to vitamin D IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mesenchymal-epithelial cell signaling involved in prostate gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in neuron projection development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in odontogenesis of dentin-containing tooth IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within peripheral nervous system axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peripheral nervous system axon regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within prostate gland epithelium morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of cell migration NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to fibroblast growth factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to wounding ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    tenascin
    Names
    hexabrachion

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001369211.1NP_001356140.1  tenascin isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL732556
      Consensus CDS
      CCDS89763.1
      UniProtKB/Swiss-Prot
      Q64706, Q80YX1, Q80YX2
      Related
      ENSMUSP00000102995.2, ENSMUST00000107372.8
      Conserved Domains (4) summary
      cd00063
      Location:624710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00147
      Location:18892098
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:408434
      EGF_2; EGF-like domain
      pfam00041
      Location:894976
      fn3; Fibronectin type III domain
    2. NM_001369212.1NP_001356141.1  tenascin isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AL732556
      UniProtKB/TrEMBL
      Q148T4
      Conserved Domains (4) summary
      cd00063
      Location:624710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00147
      Location:17071916
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:408434
      EGF_2; EGF-like domain
      pfam00041
      Location:894976
      fn3; Fibronectin type III domain
    3. NM_001369213.1NP_001356142.1  tenascin isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL732556
      Conserved Domains (4) summary
      cd00063
      Location:363449
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00147
      Location:15371746
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:147173
      EGF_2; EGF-like domain
      pfam00041
      Location:633715
      fn3; Fibronectin type III domain
    4. NM_001369214.1NP_001356143.1  tenascin isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AL732556
      UniProtKB/TrEMBL
      Q148T4, Q148T5
      Conserved Domains (4) summary
      cd00063
      Location:624710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00147
      Location:13431552
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:408434
      EGF_2; EGF-like domain
      pfam00041
      Location:894976
      fn3; Fibronectin type III domain
    5. NM_011607.3NP_035737.2  tenascin isoform 2 precursor

      See identical proteins and their annotated locations for NP_035737.2

      Status: VALIDATED

      Source sequence(s)
      AK040167, AL732556, BC117979, BY300535, CN664449
      Consensus CDS
      CCDS18265.1
      UniProtKB/Swiss-Prot
      Q80YX1
      UniProtKB/TrEMBL
      Q148T5, Q8C9Z1
      Related
      ENSMUSP00000103000.4, ENSMUST00000107377.10
      Conserved Domains (4) summary
      cd00063
      Location:624710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:894976
      fn3; Fibronectin type III domain
      pfam00147
      Location:17982007
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:408434
      EGF_2; EGF-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      63878022..63965554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537776.2XP_006537839.1  tenascin isoform X1

      UniProtKB/TrEMBL
      Q148T4
      Conserved Domains (6) summary
      cd00063
      Location:624710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00147
      Location:14341643
      Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
      pfam07974
      Location:345372
      EGF_2; EGF-like domain
      pfam00041
      Location:894976
      fn3; Fibronectin type III domain
      pfam01414
      Location:516558
      DSL; Delta serrate ligand
      pfam18720
      Location:408435
      EGF_Tenascin; Tenascin EGF domain