Cspg5 chondroitin sulfate proteoglycan 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cspg5provided by MGI
Official Full Name: chondroitin sulfate proteoglycan 5provided by MGI
Primary source: MGI:MGI:1352747
See related: Ensembl:ENSMUSG00000032482 AllianceGenome:MGI:1352747
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ngc; Caleb
Summary: This gene encodes a chondroitin sulfate proteoglycan. The encoded protein has been termed a 'part-time' proteoglycan, as chondroitin sulfate chains appear to be attached to the protein in the developing but not the adult cerebellum and retina. It is thought that this protein plays roles in dendrite branching and synapse formation. [provided by RefSeq, Oct 2009]
Expression: Biased expression in frontal lobe adult (RPKM 51.3), cortex adult (RPKM 50.7) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F2; 9 59.89 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (110072851..110091644)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (110243783..110262576)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CALEB is transiently required for synapse maturation in the cerebellum.
Title: Impaired presynaptic function and elimination of synapses at premature stages during postnatal development of the cerebellum in the absence of CALEB (CSPG5/neuroglycan C).
Despite the previously reported upregulation of Cspg5 during retinal degeneration in Rpe65/ mice, no protective effect or any involvement of Cspg5 in disease progression was identified.
Title: Retinal pigment epithelium protein of 65 kDA gene-linked retinal degeneration is not modulated by chicken acidic leucine-rich epidermal growth factor-like domain containing brain protein/Neuroglycan C/ chondroitin sulfate proteoglycan 5.
During retinal degeneration in Rpe65-/- mice, neuroglycan C(NGC) expression is induced in neural retina, but not in retinal pigment epithelium, where NGC is expressed at highest levels.
Title: Differential neuroglycan C expression during retinal degeneration in Rpe65-/- mice.
PI3K-Akt-mammalian target of rapamycin (mTOR) signaling pathway and PKC are important for CALEB/NGC-induced stimulation of dendritic branching. CALEB/NGC-induced spine morphogenesis is independent of PI3K but depends on PKC.
Title: The neural EGF family member CALEB/NGC mediates dendritic tree and spine complexity.
there is a glycosylation site for chondroitin sulfate on the neural part-time proteoglycan, neuroglycan C
Title: Glycosylation site for chondroitin sulfate on the neural part-time proteoglycan, neuroglycan C.
phosphorylation and localization in lipid rafts
Title: Phosphorylation of neuroglycan C, a brain-specific transmembrane chondroitin sulfate proteoglycan, and its localization in the lipid rafts.
neuroglycan C is a novel component of midkine receptors involved in process elongation
Title: Neuroglycan C is a novel midkine receptor involved in process elongation of oligodendroglial precursor-like cells.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in axon regeneration	IEA Inferred from Electronic Annotation more info
involved_in cell projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in glial cell projection elongation	ISO Inferred from Sequence Orthology more info
involved_in glial cell projection elongation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi-associated vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi-associated vesicle membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: chondroitin sulfate proteoglycan 5

Names: acidic leucine-rich EGF-like domain-containing brain protein; neuroglycan C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001166273.1 → NP_001159745.1 chondroitin sulfate proteoglycan 5 isoform b precursor

See identical proteins and their annotated locations for NP_001159745.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a longer protein (isoform b), compared to isoform a. Isoform b is also known as NGC-III and mCALEBb. Variant 2 contains an in-frame start site 223 codons upstream from the currently annotated site, but Kozak sequence and signal peptide considerations support use of the downstream AUG.

Source sequence(s)

AC159372, AF461092, BC055736

Consensus CDS

CCDS52936.1

UniProtKB/Swiss-Prot

E9QN54, Q71M36, Q71M37, Q7TNT8, Q8BPJ5, Q9QY32

Related

ENSMUSP00000035058.6, ENSMUST00000035058.10

Conserved Domains (2) summary

pfam06566
Location:33 → 273

Chon_Sulph_att; Chondroitin sulphate attachment domain

pfam06567
Location:447 → 565

Neural_ProG_Cyt; Neural chondroitin sulphate proteoglycan cytoplasmic domain
NM_013884.3 → NP_038912.3 chondroitin sulfate proteoglycan 5 isoform a precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (a), also known as NGC-I and mCALEBa. Variant 1 contains an in-frame start site 223 codons upstream from the currently annotated site, but Kozak sequence and signal peptide considerations support use of the downstream AUG.

Source sequence(s)

AC159372, AF133700, AF461090, BC055736

Consensus CDS

CCDS81085.1

UniProtKB/Swiss-Prot

Q71M36

Related

ENSMUSP00000143164.2, ENSMUST00000196060.5

Conserved Domains (2) summary

pfam06566
Location:33 → 273

Chon_Sulph_att; Chondroitin sulphate attachment domain

pfam06567
Location:447 → 538

Neural_ProG_Cyt; Neural chondroitin sulphate proteoglycan cytoplasmic domain