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    Rgl3 ral guanine nucleotide dissociation stimulator-like 3 [ Mus musculus (house mouse) ]

    Gene ID: 71746, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rgl3provided by MGI
    Official Full Name
    ral guanine nucleotide dissociation stimulator-like 3provided by MGI
    Primary source
    MGI:MGI:1918996
    See related
    Ensembl:ENSMUSG00000040146 AllianceGenome:MGI:1918996
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mFLJ00153; 1300003D20Rik
    Summary
    Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in Ras protein signal transduction. Predicted to act upstream of or within small GTPase-mediated signal transduction. Predicted to be active in plasma membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human RGL3 (ral guanine nucleotide dissociation stimulator like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in adrenal adult (RPKM 46.3), kidney adult (RPKM 22.1) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rgl3 in Genome Data Viewer
    Location:
    9 A3; 9 7.96 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21882475..21900765, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21971179..21989468, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 45914 Neighboring gene SWIM type zinc finger 7 associated protein 1 Neighboring gene erythropoietin receptor Neighboring gene predicted gene, 36414 Neighboring gene outer dynein arm docking complex subunit 3 Neighboring gene protein kinase C substrate 80K-H

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth. Ehrhardt GR, et al. Oncogene, 2001 Jan 11. PMID 11313946
    2. Identification of Rgl3 as a potential binding partner for Rap-family small G-proteins and profilin II. Xu J, et al. Cell Signal, 2007 Jul. PMID 17382517
    3. A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras. Shao H, et al. J Biol Chem, 2000 Sep 1. PMID 10869344
    4. Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Apr 30. PMID 15449545
    5. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within small GTPase-mediated signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ral guanine nucleotide dissociation stimulator-like 3
    Names
    RPM
    Ral guanine-nucleotide exchange factor
    RalGDS-like protein 3
    ralGDS-like 3
    ralGDS-related effector protein of M-Ras
    ras pathway modulator

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023622.5 → NP_076111.2  ral guanine nucleotide dissociation stimulator-like 3

      See identical proteins and their annotated locations for NP_076111.2

      Status: VALIDATED

      Source sequence(s)
      AC163623
      Consensus CDS
      CCDS22916.1
      UniProtKB/Swiss-Prot
      Q3UYI5, Q6KAR7, Q8BKD3, Q924M8, Q9DBL8, Q9JID4
      Related
      ENSMUSP00000035726.7, ENSMUST00000045726.8
      Conserved Domains (3) summary
      cd06224
      Location:73 → 199
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      cd00153
      Location:612 → 697
      RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
      smart00147
      Location:244 → 503
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      21882475..21900765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510613.3 → XP_006510676.1  ral guanine nucleotide dissociation stimulator-like 3 isoform X2

      Conserved Domains (3) summary
      smart00147
      Location:165 → 424
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd17212
      Location:532 → 618
      RA_RGL3; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3) and similar proteins
      cl02520
      Location:56 → 120
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

    2. XM_036155300.1 → XP_036011193.1  ral guanine nucleotide dissociation stimulator-like 3 isoform X1

      Conserved Domains (3) summary
      cd06224
      Location:73 → 199
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
      smart00147
      Location:244 → 503
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cl28922
      Location:579 → 646
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

    3. XM_036155301.1 → XP_036011194.1  ral guanine nucleotide dissociation stimulator-like 3 isoform X3

      Conserved Domains (3) summary
      smart00147
      Location:145 → 404
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd17212
      Location:512 → 598
      RA_RGL3; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3) and similar proteins
      cl02520
      Location:36 → 100
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

    4. XM_030244617.1 → XP_030100477.1  ral guanine nucleotide dissociation stimulator-like 3 isoform X2

      Conserved Domains (3) summary
      smart00147
      Location:165 → 424
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cd17212
      Location:532 → 618
      RA_RGL3; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3) and similar proteins
      cl02520
      Location:56 → 120
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...

    RNA

    1. XR_003948008.2 RNA Sequence

      Related
      ENSMUST00000214089.2

    2. XR_004935561.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UYI5.2 GenPept UniProtKB/Swiss-Prot:Q3UYI5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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