Megf6 multiple EGF-like-domains 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Megf6provided by MGI
Official Full Name: multiple EGF-like-domains 6provided by MGI
Primary source: MGI:MGI:1919351
See related: Ensembl:ENSMUSG00000057751 AllianceGenome:MGI:1919351
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Egfl3; 2600001P17Rik
Summary: Predicted to enable calcium ion binding activity and scavenger receptor activity. Predicted to be involved in vesicle-mediated transport. Located in collagen-containing extracellular matrix. Is expressed in several structures, including embryo mesenchyme; head bone; intraembryonic coelom; pharyngo-tympanic tube; and submandibular gland primordium. Orthologous to human MEGF6 (multiple EGF like domains 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 18.7), limb E14.5 (RPKM 18.6) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 83.89 cM

Exon count:: 38

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (154255156..154360178)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (154170704..154275721)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MEGF6 prevents sepsis-induced acute lung injury in mice.
Title: MEGF6 prevents sepsis-induced acute lung injury in mice.
MEGF6 promoted Colorectal Cancer Metastasis metastasis in vitro and in vivo.
Title: MEGF6 Promotes the Epithelial-to-Mesenchymal Transition via the TGFβ/SMAD Signaling Pathway in Colorectal Cancer Metastasis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BE096131 (e-PCR)
- UniSTS:243992

BB379201 (e-PCR)
- UniSTS:207737

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables scavenger receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: multiple epidermal growth factor-like domains protein 6

Names: EGF-like protein 3; EGF-like-domain, multiple 3; epidermal growth factor-like protein 3; multiple EGF-like domains protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001162977.1 → NP_001156449.1 multiple epidermal growth factor-like domains protein 6 precursor

Status: VALIDATED

Source sequence(s)

AL627123

Consensus CDS

CCDS51398.1

UniProtKB/TrEMBL

A0A0A0MQ83

Related

ENSMUSP00000030897.9, ENSMUST00000030897.15

Conserved Domains (3) summary

pfam07546
Location:42 → 111

EMI; EMI domain

pfam14670
Location:337 → 372

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:153 → 201

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

154255156..154360178

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250240.2 → XP_011248542.1 multiple epidermal growth factor-like domains protein 6 isoform X2

Conserved Domains (3) summary

pfam07546
Location:42 → 111

EMI; EMI domain

pfam14670
Location:337 → 372

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:153 → 201

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_006538826.3 → XP_006538889.1 multiple epidermal growth factor-like domains protein 6 isoform X1

Conserved Domains (3) summary

pfam07546
Location:42 → 111

EMI; EMI domain

pfam14670
Location:296 → 331

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:242 → 283

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
XM_006538827.2 → XP_006538890.1 multiple epidermal growth factor-like domains protein 6 isoform X3

Related

ENSMUSP00000121641.2, ENSMUST00000152159.8

Conserved Domains (2) summary

pfam14670
Location:229 → 264

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl00057
Location:175 → 216

vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_172273.1: Suppressed sequence

Description

NM_172273.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.