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    MARCKSL1 MARCKS like 1 [ Homo sapiens (human) ]

    Gene ID: 65108, updated on 9-Dec-2024

    Summary

    Official Symbol
    MARCKSL1provided by HGNC
    Official Full Name
    MARCKS like 1provided by HGNC
    Primary source
    HGNC:HGNC:7142
    See related
    Ensembl:ENSG00000175130 MIM:602940; AllianceGenome:HGNC:7142
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    F52; MLP; MRP; MLP1; MACMARCKS
    Summary
    This gene encodes a member of the myristoylated alanine-rich C-kinase substrate (MARCKS) family. Members of this family play a role in cytoskeletal regulation, protein kinase C signaling and calmodulin signaling. The encoded protein affects the formation of adherens junction. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on the long arm of chromosomes 6 and 10. [provided by RefSeq, Jun 2012]
    Expression
    Broad expression in ovary (RPKM 132.8), brain (RPKM 127.5) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See MARCKSL1 in Genome Data Viewer
    Location:
    1p35.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (32333839..32336233, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (32191757..32194151, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (32799440..32801834, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 587 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 588 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 683 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 684 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 590 Neighboring gene LCK proto-oncogene, Src family tyrosine kinase Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 685 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:32758549-32759123 Neighboring gene histone deacetylase 1 Neighboring gene MPRA-validated peak162 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 592 Neighboring gene uncharacterized LOC124903949 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 593 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:32801487-32802056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 686 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:32803079-32803207 Neighboring gene uncharacterized LOC105378629 Neighboring gene Sharpr-MPRA regulatory region 14076 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 596 Neighboring gene uncharacterized LOC124903933 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:32818736-32819250 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 597 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 598 Neighboring gene family with sequence similarity 229 member A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell population proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome HDA PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    MARCKS-related protein
    Names
    MARCKS-like protein 1
    mac-MARCKS
    macrophage myristoylated alanine-rich C kinase substrate

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023009.7NP_075385.1  MARCKS-related protein

      See identical proteins and their annotated locations for NP_075385.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and is protein coding.
      Source sequence(s)
      AI879076, BC007904, N70661
      Consensus CDS
      CCDS361.1
      UniProtKB/Swiss-Prot
      D3DPQ0, P49006, Q5TEE6, Q6NXS5
      Related
      ENSP00000362638.4, ENST00000329421.8
      Conserved Domains (1) summary
      pfam02063
      Location:5195
      MARCKS; MARCKS family

    RNA

    1. NR_052852.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site compared to variant 1. This variant is represented as non-coding because it lacks an in-frame coding region compared to variant 1.
      Source sequence(s)
      AL109945, BC007904, DT218825

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      32333839..32336233 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      32191757..32194151 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)