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    HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 [ Homo sapiens (human) ]

    Gene ID: 3187, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HNRNPH1provided by HGNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein H1provided by HGNC
    Primary source
    HGNC:HGNC:5041
    See related
    Ensembl:ENSG00000169045 MIM:601035; AllianceGenome:HGNC:5041
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HNRPH; HNRPH1; NEDCDS; hnRNPH
    Summary
    This gene encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. This gene may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described [provided by RefSeq, Mar 2012]
    Expression
    Ubiquitous expression in bone marrow (RPKM 153.8), lymph node (RPKM 101.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See HNRNPH1 in Genome Data Viewer
    Location:
    5q35.3
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (179614178..179634784, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (180168628..180189994, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (179041179..179061785, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC128966623 Neighboring gene RUN and FYVE domain containing 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:178998880-178999380 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:179003374-179004573 Neighboring gene peroxiredoxin 2 pseudogene 3 Neighboring gene RUFY1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:179033750-179034250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:179034251-179034751 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23754 Neighboring gene Sharpr-MPRA regulatory region 11836 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:179051499-179052283 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:179059505-179060005 Neighboring gene SPATA31 subfamily J member 1 Neighboring gene chromosome 5 open reading frame 60-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Serum exosomal hnRNPH1 mRNA as a novel marker for hepatocellular carcinoma. Xu H, et al. Clin Chem Lab Med, 2018 Feb 23. PMID 29252188
    2. Viral hijacking of hnRNPH1 unveils a G-quadruplex-driven mechanism of stress control. Schult P, et al. Cell Host Microbe, 2024 Sep 11. PMID 39094585
    3. Protein and gene expression characteristics of heterogeneous nuclear ribonucleoprotein H1 in esophageal squamous cell carcinoma. Sun YL, et al. World J Gastroenterol, 2016 Aug 28. PMID 27621578, Free PMC Article
    4. Mapping of primary congenital lymphedema to the 5q35.3 region. Evans AL, et al. Am J Hum Genet, 1999 Feb. PMID 9973292, Free PMC Article
    5. Coding and noncoding drivers of mantle cell lymphoma identified through exome and genome sequencing. Pararajalingam P, et al. Blood, 2020 Jul 30. PMID 32160292, Free PMC Article

    See all (381) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Viral hijacking of hnRNPH1 unveils a G-quadruplex-driven mechanism of stress control.
      Title: Viral hijacking of hnRNPH1 unveils a G-quadruplex-driven mechanism of stress control.
    2. Variants in HNRNPH1 are associated with high myopia in humans and ocular coloboma in zebrafish.
      Title: Variants in HNRNPH1 are associated with high myopia in humans and ocular coloboma in zebrafish.
    3. A novel HNRNPH1::ERG rearrangement in aggressive acute myeloid leukemia.
      Title: A novel HNRNPH1::ERG rearrangement in aggressive acute myeloid leukemia.
    4. Burkitt lymphoma-related TCF3 mutations alter TCF3 alternative splicing by disrupting hnRNPH1 binding.
      Title: Burkitt lymphoma-related TCF3 mutations alter TCF3 alternative splicing by disrupting hnRNPH1 binding.
    5. Coding and noncoding drivers of mantle cell lymphoma identified through exome and genome sequencing.
      Title: Coding and noncoding drivers of mantle cell lymphoma identified through exome and genome sequencing.
    6. Heterogenous Nuclear Ribonucleoprotein H1 Promotes Colorectal Cancer Progression through the Stabilization of mRNA of Sphingosine-1-Phosphate Lyase 1.
      Title: Heterogenous Nuclear Ribonucleoprotein H1 Promotes Colorectal Cancer Progression through the Stabilization of mRNA of Sphingosine-1-Phosphate Lyase 1.
    7. demonstrate that hnRNP H1 and PTBP1 regulate TCF3 AS reciprocally, and that position-dependent interactions between these factors are essential for proper TCF3 MEAS
      Title: TCF3 mutually exclusive alternative splicing is controlled by long-range cooperative actions between hnRNPH1 and PTBP1.
    8. LINC00162 overexpression increased the sensitivity, enhanced cell cycle arrest and apoptosis induced by 5-aza-dC, but did not affect its DNA demethylation effect. Mechanistically, LINC00162 interacted with an RNA splicing protein, HNRNPH1, and decreased splicing of an anti-apoptotic splicing variant, BCL-XL. LINC00162 may have translational value to predict patients who will respond to 5-aza-dC.
      Title: LINC00162 confers sensitivity to 5-Aza-2'-deoxycytidine via modulation of an RNA splicing protein, HNRNPH1.
    9. this study is the first to identify hnRNP F/H and K as regulators of Mcl-1 alternative splicing.
      Title: Regulation of Mcl-1 alternative splicing by hnRNP F, H1 and K in breast cancer cells.
    10. Sequestration of hnRNP H altered the splicing of target transcripts in C9 amyotrophic lateral sclerosis patients with GGGGCC expansion in the C9ORF72 gene. Here, the show that this signature also occurs in half of 50 postmortem sporadic, amyotrophic lateral sclerosis/frontotemporal dementia brains lacking GGGGCC expansion in the C9ORF72 gene.
      Title: Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism.
    Submit: New GeneRIF Correction See all GeneRIFs (34)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Neurodevelopmental disorder with craniofacial dysmorphism and skeletal defects
    MedGen: C5774235 OMIM: 620083 GeneReviews: Not available
    		not available

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of heterogeneous nuclear ribonucleoprotein H1 (HNRNPH1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein H1 (HNRNPH1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein H1 (HNRNPH1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein H1 (HNRNPH1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein H1 (HNRNPH1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Rev rev HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoprotein H1 (HNRNPH1), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with HNRNPH1 is increased by RRE PubMed
    Vif vif Proteins hnRNP F, hnRNP H, and hnRNP A2/B1 bind to the intronic G run (G13-2: AGGGA) to regulate the levels of vif and vpr mRNA, and the amounts of Vif and Vpr protein expression PubMed
    vif Proteins hnRNP F, hnRNP H, and hnRNP A2/B1 bind to the intronic G run (G12-1: AGGGA) to regulate the levels of vif mRNA and Vif protein expression PubMed
    Vpr vpr Proteins hnRNP F, hnRNP H, and hnRNP A2/B1 bind to the intronic G run (G13-2: AGGGA) to regulate the levels of vif and vpr mRNA, and the amounts of Vif and Vpr protein expression PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp686A15170

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables poly(U) RNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in regulation of RNA splicing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of RNA splicing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in membrane HDA PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein H
    Names
    epididymis secretory sperm binding protein
    heterogeneous nuclear ribonucleoprotein H1 (H)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001257293.2 → NP_001244222.1  heterogeneous nuclear ribonucleoprotein H isoform a

      See identical proteins and their annotated locations for NP_001244222.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a. Variants 1, 2, 12-18, and 40 all encode the same isoform (a).
      Source sequence(s)
      BC001348, BQ028714, DA204744
      Consensus CDS
      CCDS4446.1
      UniProtKB/Swiss-Prot
      B3KW86, D3DWQ2, P31943, Q6IBM4
      UniProtKB/TrEMBL
      A0A384MEJ3, B4DFK9
      Related
      ENSP00000377082.4, ENST00000393432.9
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    2. NM_001363572.2 → NP_001350501.1  heterogeneous nuclear ribonucleoprotein H isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, uses an alternate in-frame splice junction, and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 3, 24, and 46 all encode the same isoform (b).
      Source sequence(s)
      AC136604
      Consensus CDS
      CCDS87357.1
      UniProtKB/TrEMBL
      A0AAG2UY50, E9PCY7
      Related
      ENSP00000426275.1, ENST00000510411.6
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    3. NM_001364225.2 → NP_001351154.1  heterogeneous nuclear ribonucleoprotein H isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 5-8, encodes the longest isoform (c).
      Source sequence(s)
      AC136604
      Consensus CDS
      CCDS93836.1
      UniProtKB/TrEMBL
      A0AAG2UY50, G8JLB6
      Conserved Domains (4) summary
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cl17169
      Location:93 → 188
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. NM_001364226.2 → NP_001351155.1  heterogeneous nuclear ribonucleoprotein H isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 4 and 6-8, encodes isoform c.
      Source sequence(s)
      AC136604
      Consensus CDS
      CCDS93836.1
      UniProtKB/TrEMBL
      A0AAG2UY50, G8JLB6
      Conserved Domains (4) summary
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cl17169
      Location:93 → 188
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. NM_001364227.2 → NP_001351156.1  heterogeneous nuclear ribonucleoprotein H isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 4, 5, 7, and 8, encodes isoform c.
      Source sequence(s)
      AC136604
      Consensus CDS
      CCDS93836.1
      UniProtKB/TrEMBL
      A0AAG2UY50, G8JLB6
      Conserved Domains (4) summary
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cl17169
      Location:93 → 188
      RRM_SF; RNA recognition motif (RRM) superfamily

    6. NM_001364228.2 → NP_001351157.1  heterogeneous nuclear ribonucleoprotein H isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 4-6 and 8, encodes isoform c.
      Source sequence(s)
      AC136604
      Consensus CDS
      CCDS93836.1
      UniProtKB/TrEMBL
      A0AAG2UY50, G8JLB6
      Conserved Domains (4) summary
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cl17169
      Location:93 → 188
      RRM_SF; RNA recognition motif (RRM) superfamily

    7. NM_001364229.2 → NP_001351158.1  heterogeneous nuclear ribonucleoprotein H isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 4-7, encodes isoform c.
      Source sequence(s)
      AC136604
      Consensus CDS
      CCDS93836.1
      UniProtKB/TrEMBL
      A0AAG2UY50, G8JLB6
      Related
      ENSP00000327539.6, ENST00000329433.11
      Conserved Domains (4) summary
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cl17169
      Location:93 → 188
      RRM_SF; RNA recognition motif (RRM) superfamily

    8. NM_001364230.2 → NP_001351159.1  heterogeneous nuclear ribonucleoprotein H isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variant 11, encodes isoform d.
      Source sequence(s)
      AC136604
      UniProtKB/TrEMBL
      A0AAG2UWX3, A0AAG2UY50
      Conserved Domains (4) summary
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cl17169
      Location:93 → 188
      RRM_SF; RNA recognition motif (RRM) superfamily

    9. NM_001364231.2 → NP_001351160.1  heterogeneous nuclear ribonucleoprotein H isoform l

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variant 34, encodes isoform l.
      Source sequence(s)
      AC136604
      UniProtKB/TrEMBL
      A0AAG2UY50
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    10. NM_001364232.2 → NP_001351161.1  heterogeneous nuclear ribonucleoprotein H isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variant 9, encodes isoform d.
      Source sequence(s)
      AC136604
      UniProtKB/TrEMBL
      A0AAG2UWX3, A0AAG2UY50
      Conserved Domains (4) summary
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cl17169
      Location:93 → 188
      RRM_SF; RNA recognition motif (RRM) superfamily

    11. NM_001364233.2 → NP_001351162.1  heterogeneous nuclear ribonucleoprotein H isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 1, 2, 13-18, and 40, encodes isoform a.
      Source sequence(s)
      AC136604
      Consensus CDS
      CCDS4446.1
      UniProtKB/Swiss-Prot
      B3KW86, D3DWQ2, P31943, Q6IBM4
      UniProtKB/TrEMBL
      A0A384MEJ3, B4DFK9
      Related
      ENSP00000429661.2, ENST00000521116.6
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    12. NM_001364234.2 → NP_001351163.1  heterogeneous nuclear ribonucleoprotein H isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 1, 2, 12, 14-18, and 40, encodes isoform a.
      Source sequence(s)
      AC136604
      Consensus CDS
      CCDS4446.1
      UniProtKB/Swiss-Prot
      B3KW86, D3DWQ2, P31943, Q6IBM4
      UniProtKB/TrEMBL
      A0A384MEJ3, B4DFK9
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    13. NM_001364235.2 → NP_001351164.1  heterogeneous nuclear ribonucleoprotein H isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 1, 2, 12, 13, 15-18, and 40, encodes isoform a.
      Source sequence(s)
      AC136604
      Consensus CDS
      CCDS4446.1
      UniProtKB/Swiss-Prot
      B3KW86, D3DWQ2, P31943, Q6IBM4
      UniProtKB/TrEMBL
      A0A384MEJ3, B4DFK9
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    14. NM_001364236.2 → NP_001351165.1  heterogeneous nuclear ribonucleoprotein H isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 1, 2, 12-14, 16-18, and 40, encodes isoform a.
      Source sequence(s)
      AC136604
      Consensus CDS
      CCDS4446.1
      UniProtKB/Swiss-Prot
      B3KW86, D3DWQ2, P31943, Q6IBM4
      UniProtKB/TrEMBL
      A0A384MEJ3, B4DFK9
      Related
      ENSP00000426518.2, ENST00000513225.6
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    15. NM_001364237.2 → NP_001351166.1  heterogeneous nuclear ribonucleoprotein H isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 1, 2, 12-15, 17, 18, and 40, encodes isoform a.
      Source sequence(s)
      AC136604
      Consensus CDS
      CCDS4446.1
      UniProtKB/Swiss-Prot
      B3KW86, D3DWQ2, P31943, Q6IBM4
      UniProtKB/TrEMBL
      A0A384MEJ3, B4DFK9
      Related
      ENSP00000425343.2, ENST00000515714.6
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    16. NM_001364238.2 → NP_001351167.1  heterogeneous nuclear ribonucleoprotein H isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variants 1, 2, 12-16, 18, and 40, encodes isoform a.
      Source sequence(s)
      AC136604
      Consensus CDS
      CCDS4446.1
      UniProtKB/Swiss-Prot
      B3KW86, D3DWQ2, P31943, Q6IBM4
      UniProtKB/TrEMBL
      A0A384MEJ3, B4DFK9
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    17. NM_001364239.2 → NP_001351168.1  heterogeneous nuclear ribonucleoprotein H isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variants 1, 2, 12-17, and 40, encodes isoform a.
      Source sequence(s)
      AC136604
      Consensus CDS
      CCDS4446.1
      UniProtKB/Swiss-Prot
      B3KW86, D3DWQ2, P31943, Q6IBM4
      UniProtKB/TrEMBL
      A0A384MEJ3, B4DFK9
      Related
      ENSP00000421695.2, ENST00000515158.6
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    18. NM_001364240.2 → NP_001351169.1  heterogeneous nuclear ribonucleoprotein H isoform e

      Status: REVIEWED

      Source sequence(s)
      AC136604
      UniProtKB/TrEMBL
      A0A9L9PY23, A0AAG2UY50
      Related
      ENSP00000516644.1, ENST00000706924.1
      Conserved Domains (4) summary
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:282 → 357
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      pfam08080
      Location:255 → 283
      zf-RNPHF; RNPHF zinc finger
      cl17169
      Location:93 → 188
      RRM_SF; RNA recognition motif (RRM) superfamily

    19. NM_001364241.2 → NP_001351170.1  heterogeneous nuclear ribonucleoprotein H isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variants 21, 22, and 43, encodes isoform f.
      Source sequence(s)
      AC136604
      UniProtKB/TrEMBL
      B4DFK9
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 283
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:282 → 357
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    20. NM_001364242.2 → NP_001351171.1  heterogeneous nuclear ribonucleoprotein H isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variants 20, 22, and 43, encodes isoform f.
      Source sequence(s)
      AC136604
      UniProtKB/TrEMBL
      B4DFK9
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 283
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:282 → 357
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    21. NM_001364243.2 → NP_001351172.1  heterogeneous nuclear ribonucleoprotein H isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22), as well as variants 20, 21, and 43, encodes isoform f.
      Source sequence(s)
      AC136604
      UniProtKB/TrEMBL
      B4DFK9
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 283
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:282 → 357
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    22. NM_001364244.2 → NP_001351173.1  heterogeneous nuclear ribonucleoprotein H isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23), as well as variant 44, encodes isoform g.
      Source sequence(s)
      AC136604
      UniProtKB/TrEMBL
      A0AAG2UY50
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    23. NM_001364245.2 → NP_001351174.1  heterogeneous nuclear ribonucleoprotein H isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24), as well as variants 3 and 46, encodes isoform b.
      Source sequence(s)
      AC136604
      Consensus CDS
      CCDS87357.1
      UniProtKB/TrEMBL
      A0AAG2UY50, E9PCY7
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    24. NM_001364246.2 → NP_001351175.1  heterogeneous nuclear ribonucleoprotein H isoform t

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25), as well as variant 26, encodes isoform t.
      Source sequence(s)
      AC136604
      UniProtKB/TrEMBL
      A0AAG2UY50, H0YBD7
      Related
      ENSP00000429270.2, ENST00000523921.2
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    25. NM_001364247.2 → NP_001351176.1  heterogeneous nuclear ribonucleoprotein H isoform t

      Status: REVIEWED

      Description
      Transcript Variant: This variant (26), as well as variant 25, encodes isoform t.
      Source sequence(s)
      AC136604
      UniProtKB/TrEMBL
      A0AAG2UY50, H0YBD7
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    26. NM_001364248.2 → NP_001351177.1  heterogeneous nuclear ribonucleoprotein H isoform h

      Status: REVIEWED

      Source sequence(s)
      AC136604
      UniProtKB/TrEMBL
      A0AAG2UY50
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 283
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:282 → 357
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    27. NM_001364250.2 → NP_001351179.1  heterogeneous nuclear ribonucleoprotein H isoform i

      Status: REVIEWED

      Source sequence(s)
      AC136604
      Conserved Domains (3) summary
      cd12734
      Location:237 → 312
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      pfam08080
      Location:203 → 238
      zf-RNPHF; RNPHF zinc finger
      cl17169
      Location:41 → 136
      RRM_SF; RNA recognition motif (RRM) superfamily

    28. NM_001364251.2 → NP_001351180.1  heterogeneous nuclear ribonucleoprotein H isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (29), as well as variants 30 and 31, encodes isoform j.
      Source sequence(s)
      AC136604
      Conserved Domains (2) summary
      cd12734
      Location:88 → 163
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      pfam08080
      Location:54 → 89
      zf-RNPHF; RNPHF zinc finger

    29. NM_001364252.2 → NP_001351181.1  heterogeneous nuclear ribonucleoprotein H isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (30), as well as variants 29 and 31, encodes isoform j.
      Source sequence(s)
      AC136604
      Conserved Domains (2) summary
      cd12734
      Location:88 → 163
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      pfam08080
      Location:54 → 89
      zf-RNPHF; RNPHF zinc finger

    30. NM_001364253.2 → NP_001351182.1  heterogeneous nuclear ribonucleoprotein H isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (31), as well as variants 29 and 30, encodes isoform j.
      Source sequence(s)
      AC136604
      Conserved Domains (2) summary
      cd12734
      Location:88 → 163
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      pfam08080
      Location:54 → 89
      zf-RNPHF; RNPHF zinc finger

    31. NM_001364254.2 → NP_001351183.1  heterogeneous nuclear ribonucleoprotein H isoform k

      Status: REVIEWED

      Description
      Transcript Variant: This variant (32), as well as variants 33 and 51, encodes isoform k.
      Source sequence(s)
      AC136604
      Conserved Domains (2) summary
      pfam08080
      Location:54 → 89
      zf-RNPHF; RNPHF zinc finger
      cd12734
      Location:88 → 163
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    32. NM_001364255.2 → NP_001351184.1  heterogeneous nuclear ribonucleoprotein H isoform k

      Status: REVIEWED

      Description
      Transcript Variant: This variant (33), as well as variants 32 and 51, encodes isoform k.
      Source sequence(s)
      AC136604
      Conserved Domains (2) summary
      pfam08080
      Location:54 → 89
      zf-RNPHF; RNPHF zinc finger
      cd12734
      Location:88 → 163
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    33. NM_001395176.1 → NP_001382105.1  heterogeneous nuclear ribonucleoprotein H isoform l

      Status: REVIEWED

      Description
      Transcript Variant: This variant (34), as well as variant 10, encodes isoform l.
      Source sequence(s)
      AC136604
      UniProtKB/TrEMBL
      A0AAG2UY50
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    34. NM_001395177.1 → NP_001382106.1  heterogeneous nuclear ribonucleoprotein H isoform m

      Status: REVIEWED

      Source sequence(s)
      AC136604
      UniProtKB/TrEMBL
      A0AAG2UY50
      Conserved Domains (2) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cl17169
      Location:289 → 363
      RRM_SF; RNA recognition motif (RRM) superfamily

    35. NM_001395178.1 → NP_001382107.1  heterogeneous nuclear ribonucleoprotein H isoform n

      Status: REVIEWED

      Source sequence(s)
      AC136604
      UniProtKB/TrEMBL
      A0AAG2UY50
      Conserved Domains (2) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cl17169
      Location:289 → 363
      RRM_SF; RNA recognition motif (RRM) superfamily

    36. NM_001395179.1 → NP_001382108.1  heterogeneous nuclear ribonucleoprotein H isoform o

      Status: REVIEWED

      Description
      Transcript Variant: This variant (37), as well as variant 38, encodes isoform o.
      Source sequence(s)
      AC136604
      UniProtKB/TrEMBL
      A0AAG2UY50
      Conserved Domains (2) summary
      pfam08080
      Location:255 → 283
      zf-RNPHF; RNPHF zinc finger
      cl17169
      Location:282 → 356
      RRM_SF; RNA recognition motif (RRM) superfamily

    37. NM_001395180.1 → NP_001382109.1  heterogeneous nuclear ribonucleoprotein H isoform o

      Status: REVIEWED

      Description
      Transcript Variant: This variant (38), as well as variant 37, encodes isoform o.
      Source sequence(s)
      AC136604
      UniProtKB/TrEMBL
      A0AAG2UY50
      Conserved Domains (2) summary
      pfam08080
      Location:255 → 283
      zf-RNPHF; RNPHF zinc finger
      cl17169
      Location:282 → 356
      RRM_SF; RNA recognition motif (RRM) superfamily

    38. NM_001395181.1 → NP_001382110.1  heterogeneous nuclear ribonucleoprotein H isoform p

      Status: REVIEWED

      Source sequence(s)
      AC136604
      UniProtKB/TrEMBL
      A0AAG2UY50
      Conserved Domains (2) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cl17169
      Location:289 → 363
      RRM_SF; RNA recognition motif (RRM) superfamily

    39. NM_001395182.1 → NP_001382111.1  heterogeneous nuclear ribonucleoprotein H isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (40), as well as variants 1, 2, and 12-18, encodes isoform a.
      Source sequence(s)
      AC136604
      Consensus CDS
      CCDS4446.1
      UniProtKB/Swiss-Prot
      B3KW86, D3DWQ2, P31943, Q6IBM4
      UniProtKB/TrEMBL
      A0A384MEJ3, B4DFK9
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    40. NM_001395183.1 → NP_001382112.1  heterogeneous nuclear ribonucleoprotein H isoform q

      Status: REVIEWED

      Source sequence(s)
      AC136604
      UniProtKB/TrEMBL
      A0AAG2UY50
      Conserved Domains (2) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cl17169
      Location:289 → 363
      RRM_SF; RNA recognition motif (RRM) superfamily

    41. NM_001395184.1 → NP_001382113.1  heterogeneous nuclear ribonucleoprotein H isoform r

      Status: REVIEWED

      Source sequence(s)
      AC136604
      UniProtKB/TrEMBL
      A0AAG2UY50
      Conserved Domains (2) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cl17169
      Location:289 → 363
      RRM_SF; RNA recognition motif (RRM) superfamily

    42. NM_001395186.1 → NP_001382115.1  heterogeneous nuclear ribonucleoprotein H isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (43), as well as variants 20-22, encodes isoform f.
      Source sequence(s)
      AC136604
      UniProtKB/TrEMBL
      B4DFK9
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 283
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:282 → 357
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    43. NM_001395187.1 → NP_001382116.1  heterogeneous nuclear ribonucleoprotein H isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (44), as well as variant 23, encodes isoform g.
      Source sequence(s)
      AC136604
      UniProtKB/TrEMBL
      A0AAG2UY50
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    44. NM_001395188.1 → NP_001382117.1  heterogeneous nuclear ribonucleoprotein H isoform s

      Status: REVIEWED

      Source sequence(s)
      AC136604
      UniProtKB/TrEMBL
      A0AAG2UY50
      Conserved Domains (2) summary
      pfam08080
      Location:255 → 283
      zf-RNPHF; RNPHF zinc finger
      cl17169
      Location:282 → 356
      RRM_SF; RNA recognition motif (RRM) superfamily

    45. NM_001395189.1 → NP_001382118.1  heterogeneous nuclear ribonucleoprotein H isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (46), as well as variants 3 and 24, encodes isoform b.
      Source sequence(s)
      AC136604
      Consensus CDS
      CCDS87357.1
      UniProtKB/TrEMBL
      A0AAG2UY50, E9PCY7
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    46. NM_001395190.1 → NP_001382119.1  heterogeneous nuclear ribonucleoprotein H isoform u

      Status: REVIEWED

      Source sequence(s)
      AC136604
      UniProtKB/TrEMBL
      B4DFK9
      Conserved Domains (3) summary
      pfam08080
      Location:178 → 213
      zf-RNPHF; RNPHF zinc finger
      cd12731
      Location:26 → 115
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:212 → 287
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    47. NM_001395191.1 → NP_001382120.1  heterogeneous nuclear ribonucleoprotein H isoform v

      Status: REVIEWED

      Source sequence(s)
      AC136604
      Conserved Domains (3) summary
      smart00360
      Location:113 → 149
      RRM; RNA recognition motif
      pfam08080
      Location:149 → 184
      zf-RNPHF; RNPHF zinc finger
      cl17169
      Location:183 → 257
      RRM_SF; RNA recognition motif (RRM) superfamily

    48. NM_001395192.1 → NP_001382121.1  heterogeneous nuclear ribonucleoprotein H isoform w

      Status: REVIEWED

      Source sequence(s)
      AC136604
      Conserved Domains (3) summary
      smart00360
      Location:113 → 149
      RRM; RNA recognition motif
      pfam08080
      Location:149 → 184
      zf-RNPHF; RNPHF zinc finger
      cl17169
      Location:183 → 257
      RRM_SF; RNA recognition motif (RRM) superfamily

    49. NM_001395193.1 → NP_001382122.1  heterogeneous nuclear ribonucleoprotein H isoform x

      Status: REVIEWED

      Source sequence(s)
      AC136604
      Conserved Domains (2) summary
      pfam08080
      Location:130 → 153
      zf-RNPHF; RNPHF zinc finger
      cl17169
      Location:152 → 226
      RRM_SF; RNA recognition motif (RRM) superfamily

    50. NM_001395194.1 → NP_001382123.1  heterogeneous nuclear ribonucleoprotein H isoform k

      Status: REVIEWED

      Description
      Transcript Variant: This variant (51), as well as variants 32 and 33, encodes isoform k.
      Source sequence(s)
      AC136604
      Conserved Domains (2) summary
      pfam08080
      Location:54 → 89
      zf-RNPHF; RNPHF zinc finger
      cd12734
      Location:88 → 163
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    51. NM_001395195.1 → NP_001382124.1  heterogeneous nuclear ribonucleoprotein H isoform y

      Status: REVIEWED

      Source sequence(s)
      AC136604
      Conserved Domains (2) summary
      pfam08080
      Location:54 → 89
      zf-RNPHF; RNPHF zinc finger
      cl17169
      Location:88 → 162
      RRM_SF; RNA recognition motif (RRM) superfamily

    52. NM_005520.3 → NP_005511.1  heterogeneous nuclear ribonucleoprotein H isoform a

      See identical proteins and their annotated locations for NP_005511.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 12-18, and 40 all encode the same isoform (a).
      Source sequence(s)
      AK124530, BC001348, DA603645
      Consensus CDS
      CCDS4446.1
      UniProtKB/Swiss-Prot
      B3KW86, D3DWQ2, P31943, Q6IBM4
      UniProtKB/TrEMBL
      A0A384MEJ3, B4DFK9
      Related
      ENSP00000397797.2, ENST00000442819.6
      Conserved Domains (4) summary
      pfam08080
      Location:255 → 290
      zf-RNPHF; RNPHF zinc finger
      cd12729
      Location:10 → 88
      RRM1_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 1 (RRM1) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins
      cd12731
      Location:103 → 192
      RRM2_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 2 (RRM2) found in heterogeneous nuclear ribonucleoprotein hnRNP H, hnRNP H2, hnRNP F and similar proteins
      cd12734
      Location:289 → 364
      RRM3_hnRNPH_hnRNPH2_hnRNPF; RNA recognition motif 3 (RRM3) found in heterogeneous nuclear ribonucleoprotein hnRNP H , hnRNP H2, hnRNP F and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      179614178..179634784 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_016107298.1 Reference GRCh38.p14 PATCHES

      Range
      380457..401011 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      180168628..180189994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P31943.4 GenPept UniProtKB/Swiss-Prot:P31943

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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