PPIL3 peptidylprolyl isomerase like 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PPIL3provided by HGNC
Official Full Name: peptidylprolyl isomerase like 3provided by HGNC
Primary source: HGNC:HGNC:9262
See related: Ensembl:ENSG00000240344 MIM:615811; AllianceGenome:HGNC:9262
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CYPJ
Summary: This gene encodes a member of the cyclophilin family. Cyclophilins catalyze the cis-trans isomerization of peptidylprolyl imide bonds in oligopeptides. They have been proposed to act either as catalysts or as molecular chaperones in protein-folding events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2008]
Expression: Ubiquitous expression in lymph node (RPKM 8.6), ovary (RPKM 7.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 2q33.1

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (200870907..200889291, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (201354357..201372783, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (201735630..201753800, complement)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cyclophilin J expression was up-regulated in gastric carcinoma compared to normal gastric tissues.
Title: Expression and Significance of Cyclophilin J in Primary Gastric Adenocarcinoma.
CYPJ structurally resembles CYPA. It is sensitive to inhibition by CsA and plays a role in regulating cell growth, proliferation, and apoptosis.
Title: Biochemical Features of Recombinant Human Cyclophilin J.
Suppression of CYPJ could repress the growth of HCC, which makes CYPJ a potential target for the development of new strategies to treat this malignancy.
Title: Cyclophilin J is a novel peptidyl-prolyl isomerase and target for repressing the growth of hepatocellular carcinoma.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Human peptidyl-prolyl isomerase-like 3 (Ppil3) is one of the Apoptin-associated proteins.
Title: Interaction with Ppil3 leads to the cytoplasmic localization of Apoptin in tumor cells.
The novel full-length gene of human PPIL3 may be correlated with the formation of human glioma.
Title: cDNA microarray in isolation of novel differentially expressed genes related to human glioma and clone of a novel full-length gene.
Human cyclophilin J, a new member of the cyclophilin family, has been expressed and crystallized.
Title: Crystallization and preliminary X-ray crystallographic studies of human cyclophilin J.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity	IEA Inferred from Electronic Annotation more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IBA Inferred from Biological aspect of Ancestor more info
part_of catalytic step 2 spliceosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase-like 3

Names: PPIase; PPIase-like protein 3; cyclophilin J; cyclophilin-like protein 3; cyclophilin-like protein PPIL3; peptidylprolyl cis-trans isomerase-like protein 3; peptidylprolyl isomerase (cyclophilin)-like 3; rotamase PPIL3

NP_115861.1

EC 5.2.1.8

NP_570981.1

EC 5.2.1.8

XP_005246708.1

EC 5.2.1.8

XP_005246709.1

EC 5.2.1.8

XP_011509660.1

EC 5.2.1.8

XP_016859841.1

EC 5.2.1.8

XP_016859842.1

EC 5.2.1.8

XP_016859843.1

EC 5.2.1.8

XP_016859844.1

EC 5.2.1.8

XP_016859845.1

EC 5.2.1.8

XP_054198563.1

EC 5.2.1.8

XP_054198564.1

EC 5.2.1.8

XP_054198565.1

EC 5.2.1.8

XP_054198566.1

EC 5.2.1.8

XP_054198567.1

EC 5.2.1.8

XP_054198568.1

EC 5.2.1.8

XP_054198569.1

EC 5.2.1.8

XP_054198570.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032472.4 → NP_115861.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform PPIL3a

See identical proteins and their annotated locations for NP_115861.1

Status: REVIEWED

Description

Transcript Variant: This variant (PPIL3a) encodes the longer isoform (PPIL3a).

Source sequence(s)

AC005037, AF251049, AF271652

Consensus CDS

CCDS2332.1

UniProtKB/TrEMBL

A0A0S2Z5A8, B8ZZ77

Related

ENSP00000286175.8, ENST00000286175.12

Conserved Domains (1) summary

cl00197
Location:1 → 158

cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
NM_130906.3 → NP_570981.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform PPIL3b

See identical proteins and their annotated locations for NP_570981.1

Status: REVIEWED

Description

Transcript Variant: This variant (PPIL3b) includes an alternate in-frame segment, compared to variant PPIL3a, resulting in a shorter protein (isoform PPIL3b), compared to isoform PPIL3a. Variants PPIL3b and PPIL3c encode the same protein.

Source sequence(s)

AC005037, AF271652, CB961908

Consensus CDS

CCDS2333.1

UniProtKB/Swiss-Prot

Q86WF9, Q96IA9, Q9BXZ1, Q9H2H8

UniProtKB/TrEMBL

A0A024R3V4, A0A0S2Z5G0, H7BZ14

Related

ENSP00000376107.4, ENST00000392283.9

Conserved Domains (1) summary

cd01928
Location:1 → 154

Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000002.12 Reference GRCh38.p14 Primary Assembly

Range

200870907..200889291 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005246652.6 → XP_005246709.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

See identical proteins and their annotated locations for XP_005246709.1

UniProtKB/Swiss-Prot

Q86WF9, Q96IA9, Q9BXZ1, Q9H2H8

UniProtKB/TrEMBL

A0A024R3V4, A0A0S2Z5G0, H7BZ14

Conserved Domains (1) summary

cd01928
Location:1 → 154

Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...
XM_005246651.4 → XP_005246708.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

See identical proteins and their annotated locations for XP_005246708.1

UniProtKB/TrEMBL

A0A0S2Z5A8, B8ZZ77

Related

ENSP00000387012.1, ENST00000409449.5

Conserved Domains (1) summary

cl00197
Location:1 → 158

cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
XM_011511358.3 → XP_011509660.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

See identical proteins and their annotated locations for XP_011509660.1

UniProtKB/Swiss-Prot

Q86WF9, Q96IA9, Q9BXZ1, Q9H2H8

UniProtKB/TrEMBL

A0A024R3V4, A0A0S2Z5G0, H7BZ14

Related

ENST00000465823.5

Conserved Domains (1) summary

cd01928
Location:1 → 154

Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...
XM_017004352.2 → XP_016859841.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

UniProtKB/TrEMBL

A0A0S2Z5A8, B8ZZ77

Related

ENSP00000386235.1, ENST00000409361.5

Conserved Domains (1) summary

cl00197
Location:1 → 158

cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
XM_017004354.3 → XP_016859843.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

UniProtKB/TrEMBL

A0A0S2Z5A8, B8ZZ77

Conserved Domains (1) summary

cl00197
Location:1 → 158

cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...
XM_017004356.3 → XP_016859845.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

UniProtKB/Swiss-Prot

Q86WF9, Q96IA9, Q9BXZ1, Q9H2H8

UniProtKB/TrEMBL

A0A024R3V4, A0A0S2Z5G0, H7BZ14

Conserved Domains (1) summary

cd01928
Location:1 → 154

Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...
XM_017004355.3 → XP_016859844.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

UniProtKB/Swiss-Prot

Q86WF9, Q96IA9, Q9BXZ1, Q9H2H8

UniProtKB/TrEMBL

A0A024R3V4, A0A0S2Z5G0, H7BZ14

Conserved Domains (1) summary

cd01928
Location:1 → 154

Cyclophilin_PPIL3_like; Proteins similar to Human cyclophilin-like peptidylprolyl cis- trans isomerase (PPIL3). Members of this family lack a key residue important for cyclosporin binding: the tryptophan residue corresponding to W121 in human hCyP-18a; most members have a ...
XM_017004353.2 → XP_016859842.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

UniProtKB/TrEMBL

A0A0S2Z5A8, B8ZZ77

Conserved Domains (1) summary

cl00197
Location:1 → 158

cyclophilin; cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the ...

Alternate T2T-CHM13v2.0

Genomic

NC_060926.1 Alternate T2T-CHM13v2.0

Range

201354357..201372783 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054342588.1 → XP_054198563.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

UniProtKB/TrEMBL

A0A0S2Z5A8, B8ZZ77
XM_054342592.1 → XP_054198567.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

UniProtKB/Swiss-Prot

Q86WF9, Q96IA9, Q9BXZ1, Q9H2H8

UniProtKB/TrEMBL

A0A024R3V4, A0A0S2Z5G0, H7BZ14
XM_054342590.1 → XP_054198565.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

UniProtKB/TrEMBL

A0A0S2Z5A8, B8ZZ77
XM_054342593.1 → XP_054198568.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

UniProtKB/Swiss-Prot

Q86WF9, Q96IA9, Q9BXZ1, Q9H2H8

UniProtKB/TrEMBL

A0A024R3V4, A0A0S2Z5G0, H7BZ14
XM_054342589.1 → XP_054198564.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

UniProtKB/TrEMBL

A0A0S2Z5A8, B8ZZ77
XM_054342595.1 → XP_054198570.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

UniProtKB/Swiss-Prot

Q86WF9, Q96IA9, Q9BXZ1, Q9H2H8

UniProtKB/TrEMBL

A0A024R3V4, A0A0S2Z5G0, H7BZ14
XM_054342594.1 → XP_054198569.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X2

UniProtKB/Swiss-Prot

Q86WF9, Q96IA9, Q9BXZ1, Q9H2H8

UniProtKB/TrEMBL

A0A024R3V4, A0A0S2Z5G0, H7BZ14
XM_054342591.1 → XP_054198566.1 peptidyl-prolyl cis-trans isomerase-like 3 isoform X1

UniProtKB/TrEMBL

A0A0S2Z5A8, B8ZZ77

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_131916.1: Suppressed sequence

Description

NM_131916.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript, which aligns with non-consensus splice sites in the 5' UTR.