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    SNRPF small nuclear ribonucleoprotein polypeptide F [ Homo sapiens (human) ]

    Gene ID: 6636, updated on 10-Dec-2024

    Summary

    Official Symbol
    SNRPFprovided by HGNC
    Official Full Name
    small nuclear ribonucleoprotein polypeptide Fprovided by HGNC
    Primary source
    HGNC:HGNC:11162
    See related
    Ensembl:ENSG00000139343 MIM:603541; AllianceGenome:HGNC:11162
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SMF; Sm-F; snRNP-F
    Summary
    Enables RNA binding activity. Involved in spliceosomal snRNP assembly. Located in cytosol and nucleus. Part of several cellular components, including methylosome; nucleus; and pICln-Sm protein complex. Biomarker of nasopharynx carcinoma. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 26.2), colon (RPKM 24.6) and 25 other tissues See more
    Orthologs
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    Genomic context

    See SNRPF in Genome Data Viewer
    Location:
    12q23.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (95858952..95866140)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (95835373..95842560)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (96252730..96259918)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 247, pseudogene Neighboring gene SNRPF divergent transcript Neighboring gene long intergenic non-protein coding RNA 2410 Neighboring gene MPRA-validated peak1901 silencer Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 12:96243941 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 12:96244864 Neighboring gene melanoma risk locus-associated MPRA allelic enhancer 12:96249988 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:96252439-96253054 Neighboring gene coiled-coil domain containing 38 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:96301545-96302055 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:96302056-96302565 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:96322471-96322972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:96350128-96350641 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:96350642-96351154 Neighboring gene amidohydrolase domain containing 1 Neighboring gene AMDHD1 eExon liver enhancer

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, small nuclear ribonucleoprotein polypeptide F (SNRPF), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding  
    enables RNA binding PubMed 
    enables protein binding PubMed 
    Items 1 - 20 of 30
    Component Evidence Code Pubs
    part_of SMN-Sm protein complex PubMed 
    part_of U1 snRNP  
    part_of U1 snRNP PubMed 
    part_of U1 snRNP PubMed 
    part_of U1 snRNP PubMed 
    part_of U12-type spliceosomal complex PubMed 
    part_of U2 snRNP PubMed 
    part_of U2-type catalytic step 2 spliceosome PubMed 
    part_of U2-type precatalytic spliceosome PubMed 
    part_of U2-type spliceosomal complex PubMed 
    part_of U4 snRNP PubMed 
    part_of U4 snRNP PubMed 
    part_of U4/U6 x U5 tri-snRNP complex PubMed 
    part_of U4/U6 x U5 tri-snRNP complex PubMed 
    part_of U5 snRNP PubMed 
    part_of U7 snRNP PubMed 
    part_of catalytic step 2 spliceosome  
    part_of catalytic step 2 spliceosome PubMed 
    located_in cytosol PubMed 
    located_in cytosol  
    part_of methylosome PubMed 
    located_in nucleoplasm  
    located_in nucleus PubMed 
    located_in nucleus PubMed 
    part_of pICln-Sm protein complex  
    part_of pICln-Sm protein complex PubMed 
    part_of small nuclear ribonucleoprotein complex PubMed 
    part_of spliceosomal complex PubMed 
    part_of spliceosomal complex PubMed 
    part_of spliceosomal complex PubMed 
    Items 1 - 20 of 30

    General protein information

    Preferred Names
    small nuclear ribonucleoprotein F
    Names
    sm protein F

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394209.1 → NP_001381138.1  small nuclear ribonucleoprotein F isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC090001
      Conserved Domains (1) summary
      cl00259
      Location:6 → 43
      Sm_like; Sm and related proteins
    2. NM_003095.5 → NP_003086.1  small nuclear ribonucleoprotein F isoform 1

      See identical proteins and their annotated locations for NP_003086.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC090001
      Consensus CDS
      CCDS9055.1
      UniProtKB/Swiss-Prot
      A2VCR2, B2R498, P62306, Q15356, Q6IBQ1, Q6P4I0
      Related
      ENSP00000266735.5, ENST00000266735.10
      Conserved Domains (1) summary
      cd01722
      Location:6 → 74
      Sm_F; Sm protein F

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      95858952..95866140
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      95835373..95842560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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