TAS2R46 taste 2 receptor member 46 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TAS2R46provided by HGNC
Official Full Name: taste 2 receptor member 46provided by HGNC
Primary source: HGNC:HGNC:18877
See related: Ensembl:ENSG00000226761 MIM:612774; AllianceGenome:HGNC:18877
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: T2R46; T2R54
Summary: TAS2R46 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.[supplied by OMIM, Sep 2009]
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Genomic context

Location:: 12p13.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (11061365..11062294, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (10936559..10937488, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (11213964..11214893, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Bitter Taste Receptor 46 (hTAS2R46) Protects Monocytes/Macrophages from Oxidative Stress.
Title: Bitter Taste Receptor 46 (hTAS2R46) Protects Monocytes/Macrophages from Oxidative Stress.
Single-Nucleotide Polymorphisms of TAS2R46 Affect the Receptor Downstream Calcium Regulation in Histamine-Challenged Cells.
Title: Single-Nucleotide Polymorphisms of TAS2R46 Affect the Receptor Downstream Calcium Regulation in Histamine-Challenged Cells.
Structural basis for strychnine activation of human bitter taste receptor TAS2R46.
Title: Structural basis for strychnine activation of human bitter taste receptor TAS2R46.
Absinthin, an agonist of the bitter taste receptor hTAS2R46, uncovers an ER-to-mitochondria Ca(2+)-shuttling event.
Title: Absinthin, an agonist of the bitter taste receptor hTAS2R46, uncovers an ER-to-mitochondria Ca(2+)-shuttling event.
TAS2R46G>A rs2708381 is not associated with recurrent pregnancy loss in Korean women.
Title: Association study of the three functional polymorphisms (TAS2R46G>A, OR4C16G>A, and OR4X1A>T) with recurrent pregnancy loss.
Gastrointestinal cancer risk is not associated with any TAS2R46 genotypes since there were no significant differences in genotype frequencies between cancer patients and controls
Title: Genotyping Analysis of Bitter-Taste Receptor Genes TAS2R38 and TAS2R46 in Japanese Patients with Gastrointestinal Cancers.
MSC express the bitter taste receptor, TAS2R46, a protein more typically localized to the taste bud. Expression was also confirmed in VSMCs.
Title: Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484184

NoName (e-PCR)
- UniSTS:484185

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables bitter taste receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables bitter taste receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in ciliary membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IC Inferred by Curator more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: taste receptor type 2 member 46

Names: taste receptor type 2 member 54; taste receptor, type 2, member 46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001426846.1 → NP_001413775.1 taste receptor type 2 member 46 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents an alternate 'A' allele of the SNP rs2708381, which results in a premature stop codon in T2T-CHM13 genome assembly. The resulting protein lacks one transmembrane domain, and is shorter than isoform 1.

Source sequence(s)

CP068266

UniProtKB/TrEMBL

A0A0J9YY42, Q50KH1
NM_176887.2 → NP_795368.2 taste receptor type 2 member 46 isoform 1

See identical proteins and their annotated locations for NP_795368.2

Status: VALIDATED

Source sequence(s)

AC018630

Consensus CDS

CCDS53748.1

UniProtKB/Swiss-Prot

P59540, P59548, Q645X6

UniProtKB/TrEMBL

Q50KH0

Related

ENSP00000436450.1, ENST00000533467.1

Conserved Domains (1) summary

pfam05296
Location:1 → 298

TAS2R; Taste receptor protein (TAS2R)