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    PSG7 pregnancy specific beta-1-glycoprotein 7 [ Homo sapiens (human) ]

    Gene ID: 5676, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PSG7provided by HGNC
    Official Full Name
    pregnancy specific beta-1-glycoprotein 7provided by HGNC
    Primary source
    HGNC:HGNC:9524
    See related
    Ensembl:ENSG00000221878 MIM:176396; AllianceGenome:HGNC:9524
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PSG1; PSGGA; PSBG-7; PS-beta-G-7
    Summary
    This gene is a member of the pregnancy-specific glycoprotein (PSG) gene family. The PSG genes are a subgroup of the carcinoembryonic antigen (CEA) family of immunoglobulin-like genes, and are found in a gene cluster at 19q13.1-q13.2 telomeric to another cluster of CEA-related genes. The PSG genes are expressed by placental trophoblasts and released into the maternal circulation during pregnancy, and are thought to be essential for maintenance of normal pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
    Expression
    Restricted expression toward placenta (RPKM 24.2) See more
    Orthologs
    all
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    Genomic context

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    See PSG7 in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (42924132..42937207, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (45743086..45756176, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43428284..43441359, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene pregnancy specific beta-1-glycoprotein 1 Neighboring gene pregnancy specific beta-1-glycoprotein 6 Neighboring gene CEA cell adhesion molecule pseudogene 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:43497577-43497773 Neighboring gene pregnancy specific beta-1-glycoprotein 11

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Expression and transcriptional regulation of individual pregnancy-specific glycoprotein genes in differentiating trophoblast cells. Camolotto S, et al. Placenta, 2010 Apr. PMID 20116096
    2. Coordinate expression of the human pregnancy-specific glycoprotein gene family during induced and replicative senescence. Endoh M, et al. Biogerontology, 2009 Apr. PMID 18792801
    3. PSG7 and 9 (Pregnancy-Specific β-1 Glycoproteins 7 and 9): Novel Biomarkers for Preeclampsia. Kandel M, et al. J Am Heart Assoc, 2022 Apr 5. PMID 35322669, Free PMC Article
    4. The FOXF2 pathway in the human prostate stroma. van der Heul-Nieuwenhuijsen L, et al. Prostate, 2009 Oct 1. PMID 19562724
    5. Identification of a new carcinoembryonic antigen (CEA) family member in human fetal liver--cloning and sequence determination of pregnancy-specific glycoprotein 7. Khan WN, et al. Biochem Biophys Res Commun, 1990 Apr 16. PMID 2328001

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PSG7 and 9 (Pregnancy-Specific beta-1 Glycoproteins 7 and 9): Novel Biomarkers for Preeclampsia.
      Title: PSG7 and 9 (Pregnancy-Specific β-1 Glycoproteins 7 and 9): Novel Biomarkers for Preeclampsia.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in female pregnancy TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pregnancy-specific beta-1-glycoprotein 7
    Names
    pregnancy-specific glycoprotein 7
    putative pregnancy-specific beta-1-glycoprotein 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001206650.2 → NP_001193579.1  pregnancy-specific beta-1-glycoprotein 7 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
      Source sequence(s)
      AC093055, BC136401, BP321474, BX952498, DB381347, T29414
      Consensus CDS
      CCDS77310.1
      UniProtKB/TrEMBL
      A0A096LNM5, M0R0B3
      Related
      ENSP00000485117.1, ENST00000623675.3
      Conserved Domains (3) summary
      smart00410
      Location:217 → 289
      IG_like; Immunoglobulin like
      pfam13895
      Location:213 → 291
      Ig_2; Immunoglobulin domain
      cl11960
      Location:26 → 114
      Ig; Immunoglobulin domain

    2. NM_002783.3 → NP_002774.2  pregnancy-specific beta-1-glycoprotein 7 isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longest isoform (1). This version of transcript variant 1 represents the protein-coding minor allele. A second version of transcript variant 1 represents the major allele of this polymorphic locus with a mismatch compared to the reference genome sequence.
      Source sequence(s)
      AC093055, AL546656, BC030979, BG434892, BX952498, DC380850, T29414, U18467
      UniProtKB/Swiss-Prot
      A0A087WSZ1, Q13046, Q15232
      UniProtKB/TrEMBL
      A0A087WT09
      Related
      ENSP00000421986.1, ENST00000406070.7
      Conserved Domains (3) summary
      pfam13895
      Location:335 → 413
      Ig_2; Immunoglobulin domain
      cd05774
      Location:36 → 138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cl11960
      Location:148 → 236
      Ig; Immunoglobulin domain

    RNA

    1. NR_172123.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, non-coding) is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD). This version of transcript variant 1 represents the non protein-coding major allele of this polymorphic locus with a mismatch compared to the reference genome sequence. A second version of transcript variant 1 represents the protein-coding minor allele.
      Source sequence(s)
      AC005260, AC093055, BC030979

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      42924132..42937207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      45743086..45756176 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001290042.1: Suppressed sequence

      Description
      NM_001290042.1: This RefSeq was removed because it is redundant with another RefSeq (NM_002783.3), when matched to the current reference genome assembly sequence.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13046.3 GenPept UniProtKB/Swiss-Prot:Q13046

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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