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    MIR124-2HG MIR124-2 host gene [ Homo sapiens (human) ]

    Gene ID: 100130155, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MIR124-2HGprovided by HGNC
    Official Full Name
    MIR124-2 host geneprovided by HGNC
    Primary source
    HGNC:HGNC:48723
    See related
    Ensembl:ENSG00000254377 AllianceGenome:HGNC:48723
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LINC00966
    Expression
    Restricted expression toward brain (RPKM 3.5) See more
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    Genomic context

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    See MIR124-2HG in Genome Data Viewer
    Location:
    8q12.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (64373218..64387504)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (64798633..64812914)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (65285775..65300061)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1414 Neighboring gene uncharacterized LOC105375877 Neighboring gene NANOG hESC enhancer GRCh37_chr8:65281318-65281819 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:65282636-65283161 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:65283162-65283688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:65283689-65284213 Neighboring gene NANOG hESC enhancer GRCh37_chr8:65285363-65285903 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:65289123-65289700 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 8 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:65322543-65323742 Neighboring gene microRNA 124-2 Neighboring gene cytochrome c oxidase subunit NDUFA4-like Neighboring gene uncharacterized LOC124900252 Neighboring gene BHLHE22 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. miRNA-124 modulates lung carcinoma cell migration and invasion. Li Z, et al. Int J Clin Pharmacol Ther, 2016 Aug. PMID 27251409
    2. The feedback loop between miR-124 and TGF-β pathway plays a significant role in non-small cell lung cancer metastasis. Zu L, et al. Carcinogenesis, 2016 Mar. PMID 26818357
    3. miR-124 and Androgen Receptor Signaling Inhibitors Repress Prostate Cancer Growth by Downregulating Androgen Receptor Splice Variants, EZH2, and Src. Shi XB, et al. Cancer Res, 2015 Dec 15. PMID 26573802, Free PMC Article
    4. Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts. Wistow G, et al. Mol Vis, 2002 Jun 15. PMID 12107411
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. miR-124 inhibits lung cancer cell migration and invasion through suppressing epithelial-mesenchymal transition (EMT) and inducing apoptosis of the lung cancer cells.
      Title: miRNA-124 modulates lung carcinoma cell migration and invasion.
    2. data show a novel feedback loop between miR-124 and transforming growth factor-beta (TGF-beta) pathway driving non-small cell lung cancer (NSCLC) metastasis, which might provide a new insight into treatment of NSCLC progression
      Title: The feedback loop between miR-124 and TGF-β pathway plays a significant role in non-small cell lung cancer metastasis.
    3. We found that miR-124 directly downregulates the levels of AR transcript variants, as well as enhancer of Zeste homolog 2 (EZH2) and Src tyrosine kinase (Src).
      Title: miR-124 and Androgen Receptor Signaling Inhibitors Repress Prostate Cancer Growth by Downregulating Androgen Receptor Splice Variants, EZH2, and Src.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Other Names

    • MIR124-2 host gene (non-protein coding)
    • long intergenic non-protein coding RNA 966

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_034102.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon and includes an alternate 3' end, resulting in a shorter transcript compared to variant 1.
      Source sequence(s)
      AW162357, BM706891, BU726941, DB176551, R12755
      Related
      ENST00000520799.5

    2. NR_034103.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains alternate 5' and 3' exon structure, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AW162357, BM717762, BU726941, DB176551
      Related
      ENST00000772514.1

    3. NR_109792.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AC013492, AK124231, AK124256

    4. NR_109793.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains alternate 5' and 3' exon structure, resulting in a shorter transcript, compared to variant 1.
      Source sequence(s)
      AW162357, BQ639660, BU726941, BX096487, DB176551

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      64373218..64387504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      64798633..64812914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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