Tsc22d1 TSC22 domain family, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tsc22d1provided by MGI
Official Full Name: TSC22 domain family, member 1provided by MGI
Primary source: MGI:MGI:109127
See related: Ensembl:ENSMUSG00000022010 AllianceGenome:MGI:109127
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tsc; Egr5; Tsc22; TSC-22; Gm19597; Tgfb1i4
Summary: Predicted to enable identical protein binding activity and transcription coactivator activity. Involved in negative regulation of hematopoietic stem cell proliferation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human TSC22D1 (TSC22 domain family member 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 53.8), CNS E14 (RPKM 43.9) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D3; 14 40.44 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (76652401..76745205)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (76414961..76507765)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neurovascular Development in Pten and Tsc2 Mouse Mutants.
Title: Neurovascular Development in Pten and Tsc2 Mouse Mutants.
High TSC-22 expression is associated with obesity, splenic abnormality and B cell lymphoma.
Title: Overexpression of TSC-22 (transforming growth factor- β-stimulated clone-22) causes marked obesity, splenic abnormality and B cell lymphoma in transgenic mice.
These results suggested that TSC-22 could counteract the protective effect of GILZ on IL-2-deprivation-induced apoptosis.
Title: TSC-22 Promotes Interleukin-2-Deprivation Induced Apoptosis in T-Lymphocytes.
Fat4 and Tsc22d1 are likely candidate genes to influence formation of spontaneous pulmonary adenoma in aging male and female mice, respectively.
Title: Identification of fat4 and tsc22d1 as novel candidate genes for spontaneous pulmonary adenomas.
post-transcriptional regulation of Tsc-22 mediated through Ybx1, a miR-216a target, plays a key role in TGF-beta-induced Col1a2 in MC related to the pathogenesis of diabetic nephropathy
Title: Post-transcriptional up-regulation of Tsc-22 by Ybx1, a target of miR-216a, mediates TGF-{beta}-induced collagen expression in kidney cells.
novel opposing functions of the two mammalian TSC-22D1 isoforms in cell survival and proliferation, and establish the TSC-22D1 isoform 2 as a potential regulator of cell death during mammary gland involution
Title: TSC-22D1 isoforms have opposing roles in mammary epithelial cell survival.
TSC-22 normally contributes to the regulation of hematopoietic stem cell function and is a putative tumor suppressor gene that is hypermethylated and silenced in T or NK LGL leukemia.
Title: TSC-22 contributes to hematopoietic precursor cell proliferation and repopulation and is epigenetically silenced in large granular lymphocyte leukemia.
Analysis of the regulation of Tgf beta1i4 by Foxc1 in mesenchymal cells isolated from the periocular region revealed that Foxc1 negatively regulated Tgf beta1i4 expression, presumably via secreted factors such as TGF-beta1.
Title: Identification of Tgf beta1i4 as a downstream target of Foxc1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125004 (e-PCR)
- UniSTS:161826

Tsc22d1 (e-PCR), detects polymorphism
- UniSTS:547957

Egr5-rs (e-PCR), detects polymorphism
- UniSTS:142975

Tsc22d1 (e-PCR), detects polymorphism
- UniSTS:507291

AW105905 (e-PCR)
- UniSTS:180706

Tgfb1i4 (e-PCR), detects polymorphism
- UniSTS:144611

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of hematopoietic stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of positive regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of programmed cell death	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: TSC22 domain family protein 1

Names: Tgfb-stimulated clone 22 homolog; Tsc22-related inducible leucine zipper 1b; regulatory protein Tsc22; transforming growth factor beta 1 induced transcript 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001177751.2 → NP_001171222.1 TSC22 domain family protein 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC142266, AI841546, AK147039, BY720238

Consensus CDS

CCDS49545.1

UniProtKB/TrEMBL

D3YW86

Related

ENSMUSP00000099140.3, ENSMUST00000101618.9

Conserved Domains (1) summary

pfam01166
Location:22 → 68

TSC22; TSC-22/dip/bun family
NM_001310646.1 → NP_001297575.1 TSC22 domain family protein 1 isoform 4

See identical proteins and their annotated locations for NP_001297575.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and contains an alternate splice structure in its 5' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1.

Source sequence(s)

AC134842, AI841546, AW546174, CX220910

Consensus CDS

CCDS79344.1

UniProtKB/Swiss-Prot

P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4

UniProtKB/TrEMBL

D3Z0V7

Related

ENSMUSP00000106513.2, ENSMUST00000110888.8

Conserved Domains (2) summary

PHA03247
Location:486 → 796

PHA03247; large tegument protein UL36; Provisional

pfam01166
Location:910 → 956

TSC22; TSC-22/dip/bun family
NM_001310647.1 → NP_001297576.1 TSC22 domain family protein 1 isoform 5

See identical proteins and their annotated locations for NP_001297576.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, lacks the 5' and central coding regions, and initiates translation at downstream start codon, compared to variant 1. The encoded isoform (5) is significantly shorter than isoform 1.

Source sequence(s)

AI841546, AW546174, CX220910

Consensus CDS

CCDS79345.1

UniProtKB/TrEMBL

H3BLI9

Related

ENSMUSP00000135296.2, ENSMUST00000177207.2

Conserved Domains (1) summary

cl40461
Location:1 → 74

ZIP_TSC22D-like; leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins
NM_009366.4 → NP_033392.1 TSC22 domain family protein 1 isoform 2

See identical proteins and their annotated locations for NP_033392.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AI841546, AK147039

Consensus CDS

CCDS27286.1

UniProtKB/TrEMBL

Q3UXU0

Related

ENSMUSP00000022587.10, ENSMUST00000022587.10

Conserved Domains (1) summary

cd21938
Location:53 → 131

ZIP_TSC22D1; leucine zipper domain found in TSC22 domain family protein 1
NM_207652.3 → NP_997535.2 TSC22 domain family protein 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AI841546, AK147039, BC058660

Consensus CDS

CCDS27285.2

UniProtKB/Swiss-Prot

P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4

UniProtKB/TrEMBL

E9QLZ1

Related

ENSMUSP00000044517.9, ENSMUST00000048371.15

Conserved Domains (2) summary

PHA03247
Location:568 → 878

PHA03247; large tegument protein UL36; Provisional

pfam01166
Location:992 → 1038

TSC22; TSC-22/dip/bun family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

76652401..76745205

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017315943.2 → XP_017171432.1 TSC22 domain family protein 1 isoform X2

UniProtKB/Swiss-Prot

P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4

UniProtKB/TrEMBL

E9QLZ1

Conserved Domains (2) summary

PHA03247
Location:568 → 878

PHA03247; large tegument protein UL36; Provisional

pfam01166
Location:992 → 1038

TSC22; TSC-22/dip/bun family
XM_017315942.2 → XP_017171431.1 TSC22 domain family protein 1 isoform X2

UniProtKB/Swiss-Prot

P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4

UniProtKB/TrEMBL

E9QLZ1

Conserved Domains (2) summary

PHA03247
Location:568 → 878

PHA03247; large tegument protein UL36; Provisional

pfam01166
Location:992 → 1038

TSC22; TSC-22/dip/bun family
XM_006518803.4 → XP_006518866.1 TSC22 domain family protein 1 isoform X6

See identical proteins and their annotated locations for XP_006518866.1

UniProtKB/Swiss-Prot

P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4

UniProtKB/TrEMBL

D3Z0V7

Conserved Domains (2) summary

PHA03247
Location:486 → 796

PHA03247; large tegument protein UL36; Provisional

pfam01166
Location:910 → 956

TSC22; TSC-22/dip/bun family
XM_017315945.2 → XP_017171434.1 TSC22 domain family protein 1 isoform X5

UniProtKB/Swiss-Prot

P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4

Conserved Domains (1) summary

PHA03247
Location:568 → 878

PHA03247; large tegument protein UL36; Provisional
XM_006518799.3 → XP_006518862.1 TSC22 domain family protein 1 isoform X1

UniProtKB/Swiss-Prot

P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4

Conserved Domains (1) summary

PHA03247
Location:568 → 878

PHA03247; large tegument protein UL36; Provisional
XM_006518801.3 → XP_006518864.1 TSC22 domain family protein 1 isoform X4

UniProtKB/Swiss-Prot

P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4

Conserved Domains (1) summary

PHA03247
Location:568 → 878

PHA03247; large tegument protein UL36; Provisional
XM_006518800.3 → XP_006518863.1 TSC22 domain family protein 1 isoform X3

UniProtKB/Swiss-Prot

P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4

Conserved Domains (1) summary

PHA03247
Location:568 → 878

PHA03247; large tegument protein UL36; Provisional
XM_036158535.1 → XP_036014428.1 TSC22 domain family protein 1 isoform X7

UniProtKB/Swiss-Prot

P62500, Q00992, Q69Z44, Q6PDK1, Q9EQN4

Conserved Domains (1) summary

PHA03247
Location:486 → 796

PHA03247; large tegument protein UL36; Provisional