Suclg1 succinate-CoA ligase GDP/ADP-forming subunit alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Suclg1provided by RGD
Official Full Name: succinate-CoA ligase GDP/ADP-forming subunit alphaprovided by RGD
Primary source: RGD:619821
See related: EnsemblRapid:ENSRNOG00000005587 AllianceGenome:RGD:619821
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GDP binding activity; succinate-CoA ligase (ADP-forming) activity; and succinate-CoA ligase (GDP-forming) activity. Involved in succinate metabolic process; succinyl-CoA metabolic process; and tricarboxylic acid cycle. Part of succinate-CoA ligase complex (GDP-forming). Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 9. Orthologous to human SUCLG1 (succinate-CoA ligase GDP/ADP-forming subunit alpha). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 1412.9), Kidney (RPKM 1022.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q32

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (106866329..106895686)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (105308236..105337595)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (101181315..101210692)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In INS-1 832/13 cells and cultured rat islets, siRNA suppression of the GTP-producing pathway reduced glucose-stimulated insulin secretion by 50%.
Title: Mitochondrial GTP regulates glucose-stimulated insulin secretion.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU026966 (e-PCR)
- UniSTS:113760

RH129077 (e-PCR)
- UniSTS:212385

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GDP binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables succinate-CoA ligase (ADP-forming) activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate-CoA ligase (ADP-forming) activity	IDA Inferred from Direct Assay more info	PubMed
enables succinate-CoA ligase (ADP-forming) activity	IEA Inferred from Electronic Annotation more info
enables succinate-CoA ligase (GDP-forming) activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate-CoA ligase (GDP-forming) activity	IDA Inferred from Direct Assay more info	PubMed
enables succinate-CoA ligase (GDP-forming) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in succinate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in succinyl-CoA metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of succinate-CoA ligase complex (ADP-forming)	IBA Inferred from Biological aspect of Ancestor more info
part_of succinate-CoA ligase complex (GDP-forming)	IDA Inferred from Direct Assay more info	PubMed
part_of succinate-CoA ligase complex (GDP-forming)	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial

Names: SCS-alpha; succinate-CoA ligase, GDP-forming alpha subunit; succinate-CoA ligase, alpha subunit; succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial; succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial; succinyl-CoA synthetase alpha subunit; succinyl-CoA synthetase subunit alpha

NP_446204.2

EC 6.2.1.4

EC 6.2.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053752.2 → NP_446204.2 succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial precursor

See identical proteins and their annotated locations for NP_446204.2

Status: PROVISIONAL

Source sequence(s)

BC061537

UniProtKB/Swiss-Prot

P13086, Q6P7S4

UniProtKB/TrEMBL

A0A0H2UHE1, A6IAE0

Related

ENSRNOP00000007624.4, ENSRNOT00000007624.6

Conserved Domains (3) summary

PTZ00187
Location:19 → 344

PTZ00187; succinyl-CoA synthetase alpha subunit; Provisional

pfam00549
Location:199 → 324

Ligase_CoA; CoA-ligase

pfam02629
Location:53 → 146

CoA_binding; CoA binding domain