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    Mtrf1 mitochondrial translational release factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 211253, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mtrf1provided by MGI
    Official Full Name
    mitochondrial translational release factor 1provided by MGI
    Primary source
    MGI:MGI:2384815
    See related
    Ensembl:ENSMUSG00000022022 AllianceGenome:MGI:2384815
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MtRF-1; A830062K05Rik
    Summary
    Predicted to enable translation release factor activity, codon specific. Predicted to be involved in mitochondrial translational termination. Located in mitochondrion. Orthologous to human MTRF1 (mitochondrial translation release factor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 2.2), CNS E11.5 (RPKM 2.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mtrf1 in Genome Data Viewer
    Location:
    14 D3; 14 42.63 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (79635205..79672626)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (79397765..79423650)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:79691968-79692228 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:79693274-79693461 Neighboring gene regulator of cell cycle Neighboring gene N(alpha)-acetyltransferase 16, NatA auxiliary subunit Neighboring gene STARR-positive B cell enhancer ABC_E11576 Neighboring gene STARR-positive B cell enhancer ABC_E4121 Neighboring gene STARR-positive B cell enhancer ABC_E7342 Neighboring gene STARR-positive B cell enhancer ABC_E7343 Neighboring gene STARR-positive B cell enhancer ABC_E4122 Neighboring gene kelch repeat and BTB (POZ) domain containing 7 Neighboring gene STARR-positive B cell enhancer ABC_E2429 Neighboring gene kelch repeat and BTB (POZ) domain containing 6 Neighboring gene WW domain binding protein 4 Neighboring gene E74 like ETS transcription factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genetic, morphometric, and behavioral factors linked to the midsagittal area of the corpus callosum. Newbury AJ, et al. Front Genet, 2012. PMID 22666227, Free PMC Article
    2. RONIN Is an Essential Transcriptional Regulator of Genes Required for Mitochondrial Function in the Developing Retina. Poché RA, et al. Cell Rep, 2016 Feb 23. PMID 26876175, Free PMC Article
    3. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC19099

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables translation release factor activity, codon specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables translation release factor activity, codon specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translational termination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translational termination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial translational termination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peptide chain release factor 1, mitochondrial
    Names
    MRF-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145960.4 → NP_666072.3  peptide chain release factor 1, mitochondrial

      See identical proteins and their annotated locations for NP_666072.3

      Status: VALIDATED

      Source sequence(s)
      AC124745, AK043981, BB620002
      Consensus CDS
      CCDS27297.1
      UniProtKB/Swiss-Prot
      Q8K126
      UniProtKB/TrEMBL
      Q8BJY8
      Related
      ENSMUSP00000022600.3, ENSMUST00000022600.4
      Conserved Domains (3) summary
      COG0216
      Location:72 → 440
      PrfA; Protein chain release factor A [Translation, ribosomal structure and biogenesis]
      pfam00472
      Location:293 → 398
      RF-1; RF-1 domain
      pfam03462
      Location:105 → 283
      PCRF; PCRF domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      79635205..79672626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158531.1 → XP_036014424.1  peptide chain release factor 1, mitochondrial isoform X3

      UniProtKB/TrEMBL
      Q8BJY8
      Conserved Domains (1) summary
      cl40670
      Location:116 → 423
      PCRF; PCRF domain

    2. XM_036158530.1 → XP_036014423.1  peptide chain release factor 1, mitochondrial isoform X2

      UniProtKB/TrEMBL
      Q8BJY8
      Conserved Domains (1) summary
      cl40670
      Location:116 → 428
      PCRF; PCRF domain

    3. XM_017315939.2 → XP_017171428.1  peptide chain release factor 1, mitochondrial isoform X1

      UniProtKB/TrEMBL
      Q8BJY8
      Conserved Domains (1) summary
      PRK00591
      Location:116 → 452
      prfA; peptide chain release factor 1; Validated

    RNA

    1. XR_003950832.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K126.1 GenPept UniProtKB/Swiss-Prot:Q8K126

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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