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    Rbm47 RNA binding motif protein 47 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305340, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rbm47provided by RGD
    Official Full Name
    RNA binding motif protein 47provided by RGD
    Primary source
    RGD:1359713
    See related
    EnsemblRapid:ENSRNOG00000002408 AllianceGenome:RGD:1359713
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1359713
    Summary
    Predicted to enable enzyme binding activity; enzyme-substrate adaptor activity; and mRNA 3'-UTR binding activity. Predicted to be involved in positive regulation of type I interferon-mediated signaling pathway and regulation of gene expression. Predicted to act upstream of or within cytidine to uridine editing and hematopoietic progenitor cell differentiation. Predicted to be located in cytoplasm. Predicted to be part of apolipoprotein B mRNA editing enzyme complex. Predicted to be active in nucleus. Orthologous to human RBM47 (RNA binding motif protein 47). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 262.2), Adrenal (RPKM 123.2) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rbm47 in Genome Data Viewer
    Location:
    14p11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (42407226..42545304)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (42053290..42191572)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (43701944..43839803)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120096606 Neighboring gene ribosomal protein S23 like 1 Neighboring gene cholinergic receptor nicotinic alpha 9 subunit Neighboring gene HAUS augmin-like complex, subunit 8, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. C to U RNA editing mediated by APOBEC1 requires RNA-binding protein RBM47. Fossat N, et al. EMBO Rep, 2014 Aug. PMID 24916387, Free PMC Article
    2. Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7. Nagamachi A, et al. Cancer Cell, 2013 Sep 9. PMID 24029230
    3. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    4. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC94215

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA 3'-UTR binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cytidine to uridine editing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cytidine to uridine editing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of interleukin-10 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of apolipoprotein B mRNA editing enzyme complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding protein 47
    Names
    hypothetical RNA binding protein RGD1359713

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005882.1 → NP_001005882.1  RNA-binding protein 47

      See identical proteins and their annotated locations for NP_001005882.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081995
      UniProtKB/Swiss-Prot
      Q66H68
      UniProtKB/TrEMBL
      A0A8I6AD79, A6JDC5
      Related
      ENSRNOP00000003327.5, ENSRNOT00000003327.8
      Conserved Domains (1) summary
      TIGR01648
      Location:11 → 590
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      42407226..42545304
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006250951.4 → XP_006251013.1  RNA-binding protein 47 isoform X1

      See identical proteins and their annotated locations for XP_006251013.1

      UniProtKB/Swiss-Prot
      Q66H68
      UniProtKB/TrEMBL
      A0A8I6AD79, A6JDC5
      Conserved Domains (1) summary
      TIGR01648
      Location:11 → 590
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

    2. XM_063273127.1 → XP_063129197.1  RNA-binding protein 47 isoform X1

      UniProtKB/Swiss-Prot
      Q66H68
      UniProtKB/TrEMBL
      A6JDC5

    3. XM_063273128.1 → XP_063129198.1  RNA-binding protein 47 isoform X1

      UniProtKB/Swiss-Prot
      Q66H68
      UniProtKB/TrEMBL
      A6JDC5

    4. XM_063273126.1 → XP_063129196.1  RNA-binding protein 47 isoform X1

      UniProtKB/Swiss-Prot
      Q66H68
      UniProtKB/TrEMBL
      A6JDC5

    5. XM_063273129.1 → XP_063129199.1  RNA-binding protein 47 isoform X1

      UniProtKB/Swiss-Prot
      Q66H68
      UniProtKB/TrEMBL
      A6JDC5

    6. XM_063273130.1 → XP_063129200.1  RNA-binding protein 47 isoform X1

      UniProtKB/Swiss-Prot
      Q66H68
      UniProtKB/TrEMBL
      A6JDC5

    7. XM_006250949.5 → XP_006251011.1  RNA-binding protein 47 isoform X1

      See identical proteins and their annotated locations for XP_006251011.1

      UniProtKB/Swiss-Prot
      Q66H68
      UniProtKB/TrEMBL
      A0A8I6AD79, A6JDC5
      Conserved Domains (1) summary
      TIGR01648
      Location:11 → 590
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q66H68.1 GenPept UniProtKB/Swiss-Prot:Q66H68

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