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    carbonyl reductase (NADPH-dependent) [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852844, updated on 9-Dec-2024

    Summary

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    Official Full Name
    carbonyl reductase (NADPH-dependent)
    Primary source
    SGD:S000003007
    Locus tag
    YGL039W
    See related
    AllianceGenome:SGD:S000003007; FungiDB:YGL039W; VEuPathDB:YGL039W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables aldehyde dehydrogenase (NAD+) activity and carbonyl reductase (NADPH) activity. Involved in cellular ketone metabolic process and response to furfural. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (423961..425007)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene porphobilinogen synthase HEM2 Neighboring gene tRNA-Leu Neighboring gene initiation-specific alpha-1,6-mannosyltransferase Neighboring gene nicotinamidase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Efficient anaerobic whole cell stereoselective bioreduction with recombinant Saccharomyces cerevisiae. Katz M, et al. Biotechnol Bioeng, 2003 Dec 5. PMID 14574691
    2. Enantiodivergent, biocatalytic routes to both taxol side chain antipodes. Feske BD, et al. J Org Chem, 2005 Nov 11. PMID 16268655
    3. Direct enzyme assay evidence confirms aldehyde reductase function of Ydr541cp and Ygl039wp from Saccharomyces cerevisiae. Moon J, et al. Yeast, 2015 Apr. PMID 25656103
    4. Synthesis of optically pure 2-azido-1-arylethanols with isolated enzymes and conversion to triazole-containing beta-blocker analogues employing click chemistry. Ankati H, et al. J Org Chem, 2008 Aug 15. PMID 18630881
    5. Exploring redundancy in the yeast genome: an improved strategy for use of the cre-loxP system. Delneri D, et al. Gene, 2000 Jul 11. PMID 10903444

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YDR541C and YGL039W encoded an aldehyde reductase.
      Title: Direct enzyme assay evidence confirms aldehyde reductase function of Ydr541cp and Ygl039wp from Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aldehyde dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbonyl reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on CH-OH group of donors IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ketone metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to furfural IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    carbonyl reductase (NADPH-dependent)
    NP_011476.1
    • Aldehyde reductase; reduces aliphatic aldehyde substrates using NADH as cofactor; shown to reduce carbonyl compounds to chiral alcohols

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      423961..425007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180904.1 → NP_011476.1  TPA: carbonyl reductase (NADPH-dependent) [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011476.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUA0, P53183
      UniProtKB/TrEMBL
      A6ZUV6, B3LIQ0, B5VIS7, C7GT54, C8Z8K4, N1P396
      Conserved Domains (1) summary
      cd05227
      Location:7 → 324
      AR_SDR_e; aldehyde reductase, extended (e) SDRs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53183.1

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