Gata3 GATA binding protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85471, updated on 9-Dec-2024

Summary

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Official Symbol: Gata3provided by RGD
Official Full Name: GATA binding protein 3provided by RGD
Primary source: RGD:621250
See related: EnsemblRapid:ENSRNOG00000019336 AllianceGenome:RGD:621250
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables DNA-binding transcription factor activity; histone methyltransferase binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cochlea development; response to gamma radiation; and type IV hypersensitivity. Predicted to be located in chromatin and nucleoplasm. Predicted to be active in nucleus. Biomarker of asthma. Human ortholog(s) of this gene implicated in hypoparathyroidism; hypoparathyroidism-deafness-renal disease syndrome; nephrosis; and sensorineural hearing loss. Orthologous to human GATA3 (GATA binding protein 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 42.6), Kidney (RPKM 29.9) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Gata3 in Genome Data Viewer

Location:: 17q12.3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (73544234..73575670)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (68643760..68666000)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (72419752..72452043)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circ_PWWP2A promotes lung fibroblast proliferation and fibrosis via the miR-27b-3p/GATA3 axis, thereby aggravating idiopathic pulmonary fibrosis.
Title: Circ_PWWP2A promotes lung fibroblast proliferation and fibrosis via the miR-27b-3p/GATA3 axis, thereby aggravating idiopathic pulmonary fibrosis.
GATA3/long noncoding RNA MHC-R regulates the immune activity of dendritic cells in chronic obstructive pulmonary disease induced by air pollution particulate matter.
Title: GATA3/long noncoding RNA MHC-R regulates the immune activity of dendritic cells in chronic obstructive pulmonary disease induced by air pollution particulate matter.
we identified a novel, nonredundant role for GATA3 in MCs from their first appearance in embryonic kidney to mature glomeruli in health and disease. Furthermore, GATA3 expression increases inMCs in mesangial proliferative GN and haploinsufficiency of GATA3 results in MC defects, suggesting its importance for glomerular homeostasis and response to injury.
Title: A Novel Role for GATA3 in Mesangial Cells in Glomerular Development and Injury.
Data indicate there is a relationship between inflammation and imbalance in the expression of fork head-like transcription factor 3 (Foxp3), T box expressed in T cells (T-bet) and GATA binding protein 3 (GATA3) in chronic obstructive pulmonary disease.
Title: [Imbalance in the expression of Foxp3, T-bet and GATA-3 is correlated with inflammation of chronic obstructive pulmonary disease].
The imbalance of transcription factor GATA-3 and T-bet has a close correlation with the eosinophil count, and may play a key role in the formation of allergic rhinitis.
Title: [Expression of transcription factors T-bet and GATA-3 and relationship to the numbers of eosinophils in rat model of allergic rhinitis].
Both GATA-3 and T-bet were involved in allergic rhinitis, only in different phases.
Title: [Kinetic expression of T-bet and GATA-3 genes in rat allergic rhinitis models].
These results demonstrate a direct positive role of estrogen in regulating Aurora-A expression through activation of the ERalpha-GATA-3 signaling cascade
Title: Estrogen-induced aurora kinase-A (AURKA) gene expression is activated by GATA-3 in estrogen receptor-positive breast cancer cells.
retinoid nuclear transcription factors, GATA-3 and histone acetylation/deacetylation processes may have a regulatory role to play in prestin expression.
Title: Effects of retinoic acid and butyric acid on the expression of prestin and Gata-3 in organotypic cultures of the organ of corti of newborn rats.
Garlicin may upregulate the expression of T-bet dramatically and downregulate the expression of transcription factor GATA-3 in the experimental models of allergic rhinitis.
Title: [Effects of garlicin on the expression of transcription factor T-bet and GATA-3 in blood lymph cells in rats with allergic rhinitis].
study shows that GATA-3 plays critical roles in mediating survival signals in osteoblasts, possibly through upregulating bcl-x(L) gene expression
Title: GATA-3 transduces survival signals in osteoblasts through upregulation of bcl-x(L) gene expression.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Markers

Gata3 (e-PCR), detects polymorphism
- UniSTS:463209

Gata3 (e-PCR), detects polymorphism
- UniSTS:498319

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables E-box binding	ISO Inferred from Sequence Orthology more info
enables HMG box domain binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables histone methyltransferase binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables interleukin-2 receptor binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription coactivator binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within T-helper 2 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in T-helper 2 cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in TOR signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anatomical structure formation involved in morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in aortic valve morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cardiac right ventricle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cartilage development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell fate determination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to BMP stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to cytokine stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interferon-alpha	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to interleukin-4	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-4	ISO Inferred from Sequence Orthology more info
involved_in cellular response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in cochlea development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within developmental growth	ISO Inferred from Sequence Orthology more info
involved_in ear development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic hemopoiesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic organ development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of cells	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within humoral immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in kidney development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lens development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in lymphocyte migration	ISO Inferred from Sequence Orthology more info
involved_in macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in male gonad development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mast cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in mesenchymal to epithelial transition	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesonephros development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell motility	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell proliferation involved in mesonephros development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of interleukin-2 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of mammary gland epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in nephric duct formation	ISO Inferred from Sequence Orthology more info
involved_in nephric duct morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within norepinephrine biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within otic vesicle development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within parathyroid gland development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within parathyroid hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in pharyngeal system development	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T-helper 2 cell cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-13 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-13 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-4 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of interleukin-5 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-5 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of thyroid hormone generation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ureteric bud formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within post-embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pro-T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of T-helper cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cellular response to X-ray	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of establishment of cell polarity	ISO Inferred from Sequence Orthology more info
involved_in regulation of nephron tubule epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to estrogen	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to gamma radiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to virus	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sympathetic nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thymic T cell selection	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within thymus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in type IV hypersensitivity	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within ureter maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ureter morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in ureteric bud formation	ISO Inferred from Sequence Orthology more info
involved_in uterus development	ISO Inferred from Sequence Orthology more info
involved_in ventricular septum development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: trans-acting T-cell-specific transcription factor GATA-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133293.3 → NP_579827.1 trans-acting T-cell-specific transcription factor GATA-3

See identical proteins and their annotated locations for NP_579827.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A8I6A6L1, A6JLV3, F7FAR3, Q99NH5

Related

ENSRNOP00000026187.3, ENSRNOT00000026187.7

Conserved Domains (1) summary

cd00202
Location:317 → 367

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

73544234..73575670

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063276782.1 → XP_063132852.1 trans-acting T-cell-specific transcription factor GATA-3 isoform X1

UniProtKB/TrEMBL

A0A8I6A6L1, A6JLV3, F7FAR3, Q99NH5
XM_063276783.1 → XP_063132853.1 trans-acting T-cell-specific transcription factor GATA-3 isoform X2

UniProtKB/TrEMBL

A0A8I6A6L1
XM_017600667.3 → XP_017456156.1 trans-acting T-cell-specific transcription factor GATA-3 isoform X2

UniProtKB/TrEMBL

A0A8I6A6L1

Conserved Domains (1) summary

cd00202
Location:316 → 366

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
XM_063276784.1 → XP_063132854.1 trans-acting T-cell-specific transcription factor GATA-3 isoform X3
XM_063276785.1 → XP_063132855.1 trans-acting T-cell-specific transcription factor GATA-3 isoform X4
XM_008771893.3 → XP_008770115.1 trans-acting T-cell-specific transcription factor GATA-3 isoform X1

See identical proteins and their annotated locations for XP_008770115.1

UniProtKB/TrEMBL

A0A8I6A6L1, A6JLV3, F7FAR3, Q99NH5

Conserved Domains (1) summary

cd00202
Location:317 → 367

ZnF_GATA; Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C