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    Brms1l BRMS1 like transcriptional repressor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299053, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Brms1lprovided by RGD
    Official Full Name
    BRMS1 like transcriptional repressorprovided by RGD
    Primary source
    RGD:1306006
    See related
    EnsemblRapid:ENSRNOG00000008249 AllianceGenome:RGD:1306006
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable histone deacetylase binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be part of Sin3-type complex. Orthologous to human BRMS1L (BRMS1 like transcriptional repressor). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 225.0), Brain (RPKM 128.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Brms1l in Genome Data Viewer
    Location:
    6q23
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (79001803..79035735)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (73266673..73300630)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (76675399..76708261) , (76743243..76753950)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546497 Neighboring gene microRNA 3593 Neighboring gene U6 spliceosomal RNA Neighboring gene Glyceraldehyde-3-phosphate dehydrogenase, pseudogene 103

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    breast cancer metastasis-suppressor 1-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395086.1 → NP_001382015.1  breast cancer metastasis-suppressor 1-like protein

      Status: VALIDATED

      Source sequence(s)
      BC162034
      UniProtKB/TrEMBL
      A0A096MJP7, B1WC78
      Related
      ENSRNOP00000010947.5, ENSRNOT00000010948.8
      Conserved Domains (1) summary
      pfam08598
      Location:61 → 177
      Sds3; Sds3-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      79001803..79035735
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111976.2 → XP_038967904.1  breast cancer metastasis-suppressor 1-like protein isoform X2

      UniProtKB/TrEMBL
      A6HBN0, D3Z9D3
      Conserved Domains (1) summary
      pfam08598
      Location:61 → 177
      Sds3; Sds3-like

    2. XM_063261677.1 → XP_063117747.1  breast cancer metastasis-suppressor 1-like protein isoform X1

    RNA

    1. XR_010052063.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106731.1: Suppressed sequence

      Description
      NM_001106731.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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