Asf1b anti-silencing function 1B histone chaperone [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Asf1bprovided by MGI
Official Full Name: anti-silencing function 1B histone chaperoneprovided by MGI
Primary source: MGI:MGI:1914179
See related: Ensembl:ENSMUSG00000005470 AllianceGenome:MGI:1914179
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CIA-II; 1700003K02Rik
Summary: Enables histone binding activity and histone chaperone activity. Acts upstream of or within blastocyst hatching and nucleosome assembly. Located in chromatin. Is expressed in several structures, including central nervous system; cranium; ear; genitourinary system; and retina. Orthologous to human ASF1B (anti-silencing function 1B histone chaperone). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in liver E14.5 (RPKM 67.2), liver E14 (RPKM 56.9) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C2; 8 40.22 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (84682323..84696824)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (83955694..83970195)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Distinct role of histone chaperone Asf1a and Asf1b during fertilization and pre-implantation embryonic development in mice.
Title: Distinct role of histone chaperone Asf1a and Asf1b during fertilization and pre-implantation embryonic development in mice.
Loss of the histone chaperone ASF1B reduces female reproductive capacity.
Title: Loss of the histone chaperone ASF1B reduces female reproductive capacity in mice.
tousled-like kinases play important roles in DNA repair, not only by modulation of chromatin assembly via Asf1, but also by a more direct function in processing the ends of a tousled-like kinase via interaction with Rad9.
Title: TLK1B promotes repair of DSBs via its interaction with Rad9 and Asf1.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (2)
Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone binding	IDA Inferred from Direct Assay more info	PubMed
enables histone chaperone activity	IDA Inferred from Direct Assay more info	PubMed
enables histone chaperone activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA replication-dependent chromatin assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blastocyst hatching	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nucleosome assembly	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone chaperone ASF1B

Names: ASF1 anti-silencing function 1 homolog B; CCG1-interacting factor A-II; anti-silencing function protein 1 homolog B; mCIA-II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.