Fgl1 fibrinogen-like protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fgl1provided by MGI
Official Full Name: fibrinogen-like protein 1provided by MGI
Primary source: MGI:MGI:102795
See related: Ensembl:ENSMUSG00000031594 AllianceGenome:MGI:102795
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mfire1
Summary: Enables identical protein binding activity. Involved in negative regulation of T cell activation; regulation of immune response; and response to stilbenoid. Acts upstream of or within adipose tissue development; cholesterol metabolic process; and regulation of glucose metabolic process. Located in extracellular region. Orthologous to human FGL1 (fibrinogen like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward liver E18 (RPKM 174.3) See more
Orthologs: human all
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Genomic context

Location:: 8 A4; 8 23.89 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (41644471..41671015, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (41191434..41217978, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The hepatokine FGL1 regulates hepcidin and iron metabolism during anemia in mice by antagonizing BMP signaling.
Title: The hepatokine FGL1 regulates hepcidin and iron metabolism during anemia in mice by antagonizing BMP signaling.
FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation.
Title: FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation.
Fibrinogen like protein-1 knockdown suppresses the proliferation and metastasis of TU-686 cells and sensitizes laryngeal cancer to LAG-3 blockade.
Title: Fibrinogen like protein-1 knockdown suppresses the proliferation and metastasis of TU-686 cells and sensitizes laryngeal cancer to LAG-3 blockade.
Engineered Small Extracellular Vesicles as a FGL1/PD-L1 Dual-Targeting Delivery System for Alleviating Immune Rejection.
Title: Engineered Small Extracellular Vesicles as a FGL1/PD-L1 Dual-Targeting Delivery System for Alleviating Immune Rejection.
Targeting fibrinogen-like protein 1 is a novel therapeutic strategy to combat obesity.
Title: Targeting fibrinogen-like protein 1 is a novel therapeutic strategy to combat obesity.
Endoplasmic reticulum stress induced by palmitate could increase the expression of HPS in hepatocytes and further contribute to the development of insulin resistance in skeletal muscle.
Title: Hyperlipidemia-induced hepassocin in the liver contributes to insulin resistance in skeletal muscle.
The results suggest that Fgl1 acts as a tumor suppressor in hepatocellular cancer through an Akt-dependent mechanism and support its role as a potential therapeutic target in hepatocellular carcinoma.
Title: Targeted disruption of fibrinogen like protein-1 accelerates hepatocellular carcinoma development.
Hepassocin plays an important role in non-alcoholic fatty liver disease and induces hepatic lipid accumulation through an ERK1/2-dependent pathway.
Title: The role of hepassocin in the development of non-alcoholic fatty liver disease.
Fgl1 is a member of an emerging group of proteins with key roles in metabolism and liver regeneration.
Title: Targeted deletion of fibrinogen like protein 1 reveals a novel role in energy substrate utilization.
HNF1 binding site and HNF1alpha are critical to liver-specific expression of HPS, and down-regulation or loss of HNF1alpha causes, at least in part, the transcriptional down-regulation of HPS in HCC.
Title: Specific expression and regulation of hepassocin in the liver and down-regulation of the correlation of HNF1alpha with decreased levels of hepassocin in human hepatocellular carcinoma.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

General gene information

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Markers

D8Mit295 (e-PCR), detects polymorphism
- UniSTS:131507

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within adipose tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cholesterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hepatocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of T cell activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in response to stilbenoid	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fibrinogen-like protein 1

Names: MFIRE-1; fibrinogen-related protein 1; liver fibrinogen-related protein-1; mfrep-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145594.2 → NP_663569.2 fibrinogen-like protein 1 precursor

See identical proteins and their annotated locations for NP_663569.2

Status: VALIDATED

Source sequence(s)

AC156554, AF478470

Consensus CDS

CCDS22260.1

UniProtKB/Swiss-Prot

Q71KU9, Q8VC25

UniProtKB/TrEMBL

A0A0R4J0E1

Related

ENSMUSP00000034003.5, ENSMUST00000034003.5

Conserved Domains (1) summary

cd00087
Location:80 → 306

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

41644471..41671015 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242187.1 → XP_011240489.1 fibrinogen-like protein 1 isoform X1

See identical proteins and their annotated locations for XP_011240489.1

UniProtKB/Swiss-Prot

Q71KU9, Q8VC25

UniProtKB/TrEMBL

A0A0R4J0E1

Conserved Domains (1) summary

cd00087
Location:80 → 306

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
XM_011242188.4 → XP_011240490.1 fibrinogen-like protein 1 isoform X2

Conserved Domains (1) summary

cl00085
Location:80 → 199

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...