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    Card10 caspase recruitment domain family, member 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315120, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Card10provided by RGD
    Official Full Name
    caspase recruitment domain family, member 10provided by RGD
    Primary source
    RGD:1304949
    See related
    EnsemblRapid:ENSRNOG00000008401 AllianceGenome:RGD:1304949
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including activation of NF-kappaB-inducing kinase activity; negative regulation of cell migration involved in sprouting angiogenesis; and positive regulation of canonical NF-kappaB signal transduction. Predicted to be active in immunological synapse. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human CARD10 (caspase recruitment domain family member 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 106.0), Lung (RPKM 64.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Card10 in Genome Data Viewer
    Location:
    7q34
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112210944..112252044, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110330460..110371551, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (119998639..120028632, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549375 Neighboring gene extracellular leucine-rich repeat and fibronectin type III domain containing 2 Neighboring gene MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene CDC42 effector protein 1 Neighboring gene uncharacterized LOC134479608 Neighboring gene galectin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Lipopolysaccharide-induced microRNA-146a targets CARD10 and regulates angiogenesis in human umbilical vein endothelial cells. Rau CS, et al. Toxicol Sci, 2014 Aug 1. PMID 24863965
    2. Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B. Wang L, et al. J Biol Chem, 2001 Jun 15. PMID 11259443
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in activation of NF-kappaB-inducing kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration involved in sprouting angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of canonical NF-kappaB signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in immunological synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    caspase recruitment domain-containing protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130554.1 → NP_001124026.1  caspase recruitment domain-containing protein 10 isoform 1

      See identical proteins and their annotated locations for NP_001124026.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473950
      UniProtKB/TrEMBL
      A6HSM0, D4A425
      Conserved Domains (3) summary
      COG1196
      Location:147 → 450
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd08807
      Location:27 → 112
      CARD_CARD10_CARMA3; Caspase activation and recruitment domain of CARD10-like proteins
      cl17036
      Location:696 → 761
      SH3; Src Homology 3 domain superfamily

    2. NM_001434610.1 → NP_001421539.1  caspase recruitment domain-containing protein 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6HSM0, D4A425

    3. NM_001434611.1 → NP_001421540.1  caspase recruitment domain-containing protein 10 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      D4A425

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      112210944..112252044 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079260.2 → XP_038935188.1  caspase recruitment domain-containing protein 10 isoform X4

      UniProtKB/TrEMBL
      D4A425
      Conserved Domains (3) summary
      COG1196
      Location:147 → 450
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd08807
      Location:27 → 112
      CARD_CARD10_CARMA3; Caspase activation and recruitment domain of CARD10-like proteins
      cl17036
      Location:735 → 800
      SH3; Src Homology 3 domain superfamily

    2. XM_063263609.1 → XP_063119679.1  caspase recruitment domain-containing protein 10 isoform X4

      UniProtKB/TrEMBL
      D4A425

    3. XM_063263610.1 → XP_063119680.1  caspase recruitment domain-containing protein 10 isoform X4

      UniProtKB/TrEMBL
      D4A425

    4. XM_039079258.2 → XP_038935186.1  caspase recruitment domain-containing protein 10 isoform X2

      Conserved Domains (3) summary
      COG1196
      Location:196 → 499
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd08807
      Location:76 → 161
      CARD_CARD10_CARMA3; Caspase activation and recruitment domain of CARD10-like proteins
      cl17036
      Location:784 → 849
      SH3; Src Homology 3 domain superfamily

    5. XM_039079257.2 → XP_038935185.1  caspase recruitment domain-containing protein 10 isoform X1

      Conserved Domains (3) summary
      COG1196
      Location:196 → 499
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd08807
      Location:76 → 161
      CARD_CARD10_CARMA3; Caspase activation and recruitment domain of CARD10-like proteins
      cl17036
      Location:784 → 849
      SH3; Src Homology 3 domain superfamily

    6. XM_063263608.1 → XP_063119678.1  caspase recruitment domain-containing protein 10 isoform X3

      Related
      ENSRNOP00000011215.6, ENSRNOT00000011215.8

    7. XM_039079261.2 → XP_038935189.1  caspase recruitment domain-containing protein 10 isoform X5

      Conserved Domains (2) summary
      COG1196
      Location:196 → 499
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd08807
      Location:76 → 161
      CARD_CARD10_CARMA3; Caspase activation and recruitment domain of CARD10-like proteins
    Nucleotide Protein Strain
    Heading Accession and Version

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